Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sylvia E. Escher"'
Autor:
Matthias M. Wehr, Stella Marie Reamon-Buettner, Detlef Ritter, Jan Knebel, Monika Niehof, Sylvia E. Escher
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Next-generation risk assessment relies on mechanistic data from new approach methods, including transcriptome data. Various technologies, such as high-throughput targeted sequencing methods and microarray technologies based on hybridization
Externí odkaz:
https://doaj.org/article/11e16239a00c42b6a2cfd059b284d4dc
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
For many industrial chemicals toxicological data is sparse regarding several regulatory endpoints, so there is a high and often unmet demand for NAMs that allow for screening and prioritization of these chemicals. In this proof of concept case study
Externí odkaz:
https://doaj.org/article/7824a62fc0ef41bfba6176412284a191
Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones
Autor:
Christina Drake, Matthias M. Wehr, Walter Zobl, Jeannette Koschmann, David De Lucca, Britta A. Kühne, Tanja Hansen, Jan Knebel, Detlef Ritter, Jan Boei, Harry Vrieling, Annette Bitsch, Sylvia E. Escher
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo data indicate that the α-diketone diacetyl induc
Externí odkaz:
https://doaj.org/article/ef322cf5e85e456eb141e4eefa521a86
Autor:
Monika Batke, Fatemeh Moradi Afrapoli, Rupert Kellner, James F. Rathman, Chihae Yang, Mark T. D. Cronin, Sylvia E. Escher
Publikováno v:
Frontiers in Toxicology, Vol 3 (2021)
The Threshold of Toxicological Concern (TTC) concept can be applied to organic compounds with the known chemical structure to derive a threshold for exposure, below which a toxic effect on human health by the compound is not expected. The TTC concept
Externí odkaz:
https://doaj.org/article/94a1725ac32c45b78c0406d6254c6e57
Publikováno v:
Data in Brief, Vol 11, Iss C, Pp 204-207 (2017)
Hyperbilirubinemia is a pathological condition, very often indicative of underlying liver condition that is characterized by excessive accumulation of conjugated or unconjugated bilirubin in sinusoidal blood. In literature there are several indicatio
Externí odkaz:
https://doaj.org/article/43bc47672a4a4220879ea5d2c75155a0
Publikováno v:
Archives of Toxicology. 96:3033-3051
Valproic acid is a frequently used antiepileptic drug and known pediatric hepatotoxic agent. In search of pharmaceuticals with increased effectiveness and reduced toxicity, analogue chemicals came into focus. So far, toxicity and teratogenicity data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381140ef55e302a018dffe2751f3d7b0
https://doi.org/10.1007/s00204-022-03340-z
https://doi.org/10.1007/s00204-022-03340-z
Autor:
Nanette G, Vrijenhoek, Matthias M, Wehr, Steven J, Kunnen, Lukas S, Wijaya, Giulia, Callegaro, Martijn J, Moné, Sylvia E, Escher, Bob, Van de Water
Publikováno v:
ALTEX : Alternatives to Animal Experimentation
ALTEX
ALTEX
Chemical read-across is commonly evaluated without particular knowledge of the biological mechanisms leading to observed adverse outcomes in vivo. Integrating data that indicate shared modes of action in humans will strengthen read-across cases. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e2256765890ee51972b634035aa790
http://hdl.handle.net/1887/3279365
http://hdl.handle.net/1887/3279365
Autor:
Sylvia E, Escher, Susan P, Felter, Heli, Hollnagel, Alan R, Boobis, Chihae, Yang, James, Rathman, Mark T D, Cronin, Monika, Batke
Publikováno v:
ALTEX.
Threshold of toxicological concern (TTC) values are frequently used for compounds occurring at low concentrations in feed and food or as impurities in drugs. This workshop report addresses the emerging alternatives for deriving TTC values for DNA rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8dcf779bbc7d2e82056afe344bbedd
https://doi.org/10.14573/altex.2210111
https://doi.org/10.14573/altex.2210111
Publikováno v:
Chemical Research in Toxicology
Hepatic steatosis (fatty liver) is a severe liver disease induced by the excessive accumulation of fatty acids in hepatocytes. In this study, we developed reliable in silico models for predicting hepatic steatosis on the basis of an in vivo data set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::335b8ec5846f0ef7d56fd5156162b6af
https://pubmed.ncbi.nlm.nih.gov/33347274
https://pubmed.ncbi.nlm.nih.gov/33347274
Autor:
Domenico, Gadaleta, Marco, Marzo, Andrey, Toropov, Alla, Toropova, Giovanna J, Lavado, Sylvia E, Escher, Jean Lou C M, Dorne, Emilio, Benfenati
Publikováno v:
Chemical research in toxicology. 34(2)
Repeated-dose toxicity (RDT) is a critical endpoint for hazard characterization of chemicals and is assessed to derive safe levels of exposure for human health. Here we present the first attempt to model simultaneously no-observed-(adverse)-effect le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b2423a2e2e1b9a0694bf4ae82271d2b
https://pubmed.ncbi.nlm.nih.gov/32664725
https://pubmed.ncbi.nlm.nih.gov/32664725