Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sylvia Cechova"'
Autor:
Andrew P. Morris, Thu H. Le, Haojia Wu, Artur Akbarov, Peter J. van der Most, Gibran Hemani, George Davey Smith, Anubha Mahajan, Kyle J. Gaulton, Girish N. Nadkarni, Adan Valladares-Salgado, Niels Wacher-Rodarte, Josyf C. Mychaleckyj, Nicole D. Dueker, Xiuqing Guo, Yang Hai, Jeffrey Haessler, Yoichiro Kamatani, Adrienne M. Stilp, Gu Zhu, James P. Cook, Johan Ärnlöv, Susan H. Blanton, Martin H. de Borst, Erwin P. Bottinger, Thomas A. Buchanan, Sylvia Cechova, Fadi J. Charchar, Pei-Lun Chu, Jeffrey Damman, James Eales, Ali G. Gharavi, Vilmantas Giedraitis, Andrew C. Heath, Eli Ipp, Krzysztof Kiryluk, Holly J. Kramer, Michiaki Kubo, Anders Larsson, Cecilia M. Lindgren, Yingchang Lu, Pamela A. F. Madden, Grant W. Montgomery, George J. Papanicolaou, Leslie J. Raffel, Ralph L. Sacco, Elena Sanchez, Holger Stark, Johan Sundstrom, Kent D. Taylor, Anny H. Xiang, Aleksandra Zivkovic, Lars Lind, Erik Ingelsson, Nicholas G. Martin, John B. Whitfield, Jianwen Cai, Cathy C. Laurie, Yukinori Okada, Koichi Matsuda, Charles Kooperberg, Yii-Der Ida Chen, Tatjana Rundek, Stephen S. Rich, Ruth J. F. Loos, Esteban J. Parra, Miguel Cruz, Jerome I. Rotter, Harold Snieder, Maciej Tomaszewski, Benjamin D. Humphreys, Nora Franceschini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Estimated glomerular filtration rate (eGFR) is a measure of kidney function used to define chronic kidney disease. Here, Morris et al. perform trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals and identify novel loci and downstre
Externí odkaz:
https://doaj.org/article/b8a9cf68600449b683542f422dc012d2
Autor:
Yogesh Scindia, Ewa Wlazlo, Joseph Leeds, Valentina Loi, Jonathan Ledesma, Sylvia Cechova, Elizabeth Ghias, Sundararaman Swaminathan
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepc
Externí odkaz:
https://doaj.org/article/f7ae606d453043dd8e6a33268377eb39
Autor:
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007345 (2018)
[This corrects the article DOI: 10.1371/journal.pgen.1006728.].
Externí odkaz:
https://doaj.org/article/213e0f9e85ad4187b8637136ca905e08
Autor:
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006728 (2017)
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify
Externí odkaz:
https://doaj.org/article/3532e4699b9641beb8d3163da545010d
Autor:
Pei-Lun Chu, Joseph C. Gigliotti, Sylvia Cechova, Gabor Bodonyi-Kovacs, Yves T. Wang, Luojing Chen, Sylvia Wassertheil-Smoller, Jianwen Cai, Brant E. Isakson, Nora Franceschini, Thu H. Le
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F30-F42
The findings of our study are significant in several ways: 1) loss of an amino acid chaperone in the proximal tubule is sufficient to cause hypertension, 2) the results in global and proximal tubule-specific collectrin knockout mice support the notio
Autor:
Pei-Lun, Chu, Joseph C, Gigliotti, Sylvia, Cechova, Gabor, Bodonyi-Kovacs, Yves T, Wang, Luojing, Chen, Sylvia, Wassertheil-Smoller, Jianwen, Cai, Brant E, Isakson, Nora, Franceschini, Thu H, Le
Publikováno v:
American journal of physiology. Renal physiology. 324(1)
Collectrin (
Autor:
Valentina Loi, Didier Portilla, Sundararaman Swaminathan, Yogesh Scindia, Elizabeth Ghias, Ewa Wlazlo, Sylvia Cechova, Joseph Leeds, Jonathan Ledesma
Publikováno v:
Am J Physiol Renal Physiol
Acute kidney injury (AKI) is a frequent complication of sepsis and an important cause of morbidity and mortality worldwide. A cornerstone of sepsis-associated AKI is dysregulated inflammation, leading to increased tissue oxidative stress and free rad
Autor:
Cathro Helen, Yogesh Scindia, Sylvia Cechova, Ewa Wlazlo, Jonathan Ledesma, Valentina Loi, Joseph Leeds, Sundararaman Swaminathan, Elizabeth Ghias
Publikováno v:
Kidney International. 98:100-115
Lupus nephritis is the end organ manifestation of systemic lupus erythematosus. Iron metabolism and its master regulator, hepcidin, are known to regulate cell proliferation and inflammation, but their direct role in the pathophysiology of lupus nephr
Autor:
Guang Yang, Yves T. Wang, Bing Yu, Gabor Bodonyi-Kovacs, Phillip Ruiz, Janet V. Cross, Anna Köttgen, Eric Boerwinkle, Megan L. Grove, Nhu T. Nguyen, Adrienne Tin, Sylvia Cechova, Fang Chan, Josef Coresh, Shirin Pourafshar, Casey M. Rebholz, Sun-Sang J. Sung, Joseph C. Gigliotti, Robert B. Scharpf, Morgan E. Grams, Thu H. Le
Publikováno v:
J Am Soc Nephrol
Background GSTM1 encodes glutathione S-transferase μ-1 (GSTM1), which belongs to a superfamily of phase 2 antioxidant enzymes. The highly prevalent GSTM1 deletion variant is associated with kidney disease progression in human cohorts: the African Am
Autor:
Joseph S. Dolina, Christine K. Rudy, Young S. Hahn, William W. Tang, Sun-Sang J. Sung, Thu H. Le, Joey Lee, Sylvia Cechova
Publikováno v:
The Journal of Immunology. 198:2341-2351
Cross-presentation is a modular series of intracellular events dictating the internalization and subsequent MHC class I (MHC I) display of extracellular Ags. This process has been defined in dendritic cells and plays a fundamental role in the inducti