Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Sylvia C Hewitt"'
Autor:
Wipawee Winuthayanon, Miranda L Bernhardt, Elizabeth Padilla-Banks, Page H Myers, Matthew L Edin, Fred B Lih, Sylvia C Hewitt, Kenneth S Korach, Carmen J Williams
Publikováno v:
eLife, Vol 4 (2015)
Development of uterine endometrial receptivity for implantation is orchestrated by cyclic steroid hormone-mediated signals. It is unknown if these signals are necessary for oviduct function in supporting fertilization and preimplantation development.
Externí odkaz:
https://doaj.org/article/7b93fb6fdb574e07b6fc3a3f87f88db2
Autor:
Sylvia C. Hewitt, Mackenzie J. Dickson, Nicole Edwards, Kathleen Hampton, Stavros Garantziotis, Francesco J. DeMayo
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Diseases impacting the female reproductive tract pose a critical health concern. The establishment of in vitro models to study primary endometrial cells is crucial to understanding the mechanisms that contribute to normal endometrial function and the
Externí odkaz:
https://doaj.org/article/aba2f287771b46bf833ffe41d2b3e31c
Autor:
Laurel A. Coons, Adam B. Burkholder, Sylvia C. Hewitt, Donald P. McDonnell, Kenneth S. Korach
Publikováno v:
iScience, Vol 15, Iss , Pp 552-591 (2019)
Summary: Understanding why a transcription factor (TF) binds to a specific DNA element in the genome and whether that binding event affects transcriptional output remains a great challenge. In this study, we demonstrate that TF binding in the genome
Externí odkaz:
https://doaj.org/article/db4cc1500bcd499a88dba23c1addf024
Autor:
Sylvia C. Hewitt, San-pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer, Francesco J. DeMayo
Publikováno v:
Cells, Vol 11, Iss 11, p 1760 (2022)
For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding chromatin at
Externí odkaz:
https://doaj.org/article/31d698f5e02d4e458c3eb9aeac15f1e3
Autor:
Beibei Xu, Camille Allard, Ana I. Alvarez-Mercado, Taylor Fuselier, Jun Ho Kim, Laurel A. Coons, Sylvia C. Hewitt, Fumihiko Urano, Kenneth S. Korach, Ellis R. Levin, Peter Arvan, Z. Elizabeth Floyd, Franck Mauvais-Jarvis
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 181-196 (2018)
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress
Externí odkaz:
https://doaj.org/article/4ed6cc3a8e59434e9fa345e0606e3cf1
Autor:
Wipawee Winuthayanon, Sydney L. Lierz, Karena C. Delarosa, Skylar R. Sampels, Lauren J. Donoghue, Sylvia C. Hewitt, Kenneth S. Korach
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal
Externí odkaz:
https://doaj.org/article/8688e9eb254b477c9b007249a18d3a50
Autor:
Genevieve V. Dall, Jessica L. Vieusseux, Kenneth S. Korach, Yukitomo Arao, Sylvia C. Hewitt, Katherine J. Hamilton, Elaine Dzierzak, Wah Chin Boon, Evan R. Simpson, Robert G. Ramsay, Torsten Stein, Joanne S. Morris, Robin L. Anderson, Gail P. Risbridger, Kara L. Britt
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 417-431 (2017)
Estrogen stimulates breast development during puberty and mammary tumors in adulthood through estrogen receptor-α (ERα). These effects are proposed to occur via ERα+ luminal cells and not the mammary stem cells (MaSCs) that are ERαneg. Since ERα
Externí odkaz:
https://doaj.org/article/451b048dd31a4d51af09091027b98444
Autor:
Yukitomo Arao, Artiom Gruzdev, Gregory J Scott, Manas K Ray, Lauren J Donoghue, Thomas I Neufeld, Sydney L Lierz, Megan L Stefkovich, Emilie Mathura, Tanner Jefferson, Julie F Foley, Beth W Mahler, Arvand Asghari, Courtney Le, Bradley K McConnell, Robert Stephen, Brian R Berridge, Katherine J Hamilton, Sylvia C Hewitt, Michihisa Umetani, Kenneth S Korach
Publikováno v:
J Endocr Soc
Nongenomic effects of estrogen receptor α (ERα) signaling have been described for decades. Several distinct animal models have been generated previously to analyze the nongenomic ERα signaling (eg, membrane-only ER, and ERαC451A). However, the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7ee00f8896a78fd9d0dcd418386945
https://doi.org/10.1210/jendso/bvac109
https://doi.org/10.1210/jendso/bvac109
Publikováno v:
J Biol Chem
Estrogen receptor α (ERα) modulates gene expression by interacting with chromatin regions that are frequently distal from the promoters of estrogen-regulated genes. Active chromatin-enriched “super-enhancer” (SE) regions, mainly observed in in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5219f70df46bfe510d006c15c79b9e00
https://doi.org/10.1074/jbc.ra120.013666
https://doi.org/10.1074/jbc.ra120.013666
Autor:
Artiom Gruzdev, Marleny Garcia, Sara A. Grimm, Kenneth S. Korach, Katherine J. Hamilton, Francesco J. DeMayo, Sydney L. Lierz, Sylvia C. Hewitt, John P. Lydon
Publikováno v:
Journal of Biological Chemistry. 294:9746-9759
Insulin-like growth factor 1 (IGF1) is primarily synthesized in and secreted from the liver; however, estrogen (E2), through E2 receptor α (ERα), increases uterine Igf1 mRNA levels. Previous ChIP-seq analyses of the murine uterus have revealed a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5f1beca101014f471615ab8ba5cf63b
https://doi.org/10.1074/jbc.ra119.008759
https://doi.org/10.1074/jbc.ra119.008759