Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Sylvia B. Smith"'
Autor:
Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Sylvia B. Smith, Graydon B. Gonsalvez, Kathryn E. Bollinger
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerative diseases to cancer and COVID-19. S1R is ubiquitously expressed throughout the visceral organs, nervous, immune and cardiovasc
Externí odkaz:
https://doaj.org/article/5fa23cfe8ef44a56808b7703df49b7a6
Autor:
Luming Guo, Xiaoling Xie, Jing Wang, Haiyan Xiao, Shuchun Li, Mei Xu, Ebenezer Quainoo, Rithwik Koppaka, Jiaping Zhuo, Sylvia B. Smith, Lin Gan
Publikováno v:
Cells, Vol 12, Iss 15, p 1951 (2023)
Retinal ganglion cells (RGCs) are the sole output neurons conveying visual stimuli from the retina to the brain, and dysfunction or loss of RGCs is the primary determinant of visual loss in traumatic and degenerative ocular conditions. Currently, the
Externí odkaz:
https://doaj.org/article/b892c37516824b4ab55a0a5eacb83342
Autor:
Matthew R. Porter, Haiyan Xiao, Sanjay Maity, Nora Vail, Sylvia B. Smith, Joseph J. Topczewski
Publikováno v:
ACS Omega, Vol 5, Iss 50, Pp 32724-32737 (2020)
Externí odkaz:
https://doaj.org/article/620419c85bbe407281a4084f471c859d
Autor:
Shannon R. Barwick, Mevish S. Siddiq, Jing Wang, Haiyan Xiao, Brendan Marshall, Elizabeth Perry, Sylvia B. Smith
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 981 (2021)
Sigma 1 receptor (Sig1R), a modulator of cell survival, has emerged as a novel target for retinal degenerative disease. Studies have shown that activation of Sig1R, using the high affinity ligand (+)-pentazocine ((+)-PTZ), improves cone function in a
Externí odkaz:
https://doaj.org/article/5b4bafe863b1477c854967782a42bc36
Autor:
Soumya Navneet, Jing Zhao, Jing Wang, Barbara Mysona, Shannon Barwick, Navneet Ammal Kaidery, Alan Saul, Ismail Kaddour-Djebbar, Wendy B. Bollag, Bobby Thomas, Kathryn E. Bollinger, Sylvia B. Smith
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
Hyperhomocysteinemia (Hhcy), or increased levels of the excitatory amino acid homocysteine (Hcy), is implicated in glaucoma, a disease characterized by increased oxidative stress and loss of retinal ganglion cells (RGCs). Whether Hhcy is causative or
Externí odkaz:
https://doaj.org/article/ff920b2cdd234131b9890e4056bde9b7
Autor:
Ahmed S. Ibrahim, Sally Elshafey, Hassan Sellak, Khaled A. Hussein, Mohamed El-Sherbiny, Mohammed Abdelsaid, Nasser Rizk, Selina Beasley, Amany M. Tawfik, Sylvia B. Smith, Mohamed Al-Shabrawey
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 599-611 (2015)
Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived metabolites, in this proces
Externí odkaz:
https://doaj.org/article/a9eac5bb558f49d4ab2ac1cd032e6672
Diabetes Accelerates Retinal Neuronal Cell Death In A Mouse Model of Endogenous Hyperhomocysteinemia
Publikováno v:
Ophthalmology and Eye Diseases, Vol 2009, Iss 1, Pp 3-11 (2009)
Hyperhomocysteinemia has been implicated in visual dysfunction. We reported recently that mice with endogenous hyperhomocysteinemia, due to mutation of the cystathionine-β-synthase (cbs) gene, demonstrate loss of neurons in the retinal ganglion cell
Externí odkaz:
https://doaj.org/article/4b7f862b6071481a9fae17099af93364
Publikováno v:
Neurobiology of Disease, Vol 6, Iss 6, Pp 523-532 (1999)
Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor superfamily produced by retinal pigment epithelial cells in the developing and adult retina. In vitro, it induces neuronal differentiation of retinoblastoma cells a
Externí odkaz:
https://doaj.org/article/6f1cd77376d34aac99258555a7d4db38
Autor:
Patricia V. Schoenlein, John T. Barrett, Sylvia B. Smith, Jim Rawson, Darren Browning, Marlena J. Smith, Manish Shah, Sudharsan Periyasamy Thandavan, Jennifer Duplantier, Virgil T. Gaddy, Julia S. Samaddar
This study identifies macroautophagy as a key mechanism of cell survival in estrogen receptor–positive (ER+) breast cancer cells undergoing treatment with 4-hydroxytamoxifen (4-OHT). This selective ER modifier is an active metabolite of tamoxifen c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318291148195291f5e3ed5f1229c4451
https://doi.org/10.1158/1535-7163.c.6530883
https://doi.org/10.1158/1535-7163.c.6530883
Autor:
Patricia V. Schoenlein, John T. Barrett, Sylvia B. Smith, Jim Rawson, Darren Browning, Marlena J. Smith, Manish Shah, Sudharsan Periyasamy Thandavan, Jennifer Duplantier, Virgil T. Gaddy, Julia S. Samaddar
Supplementary Fig. S1 from A role for macroautophagy in protection against 4-hydroxytamoxifen–induced cell death and the development of antiestrogen resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b5f3d71710b262b3a48d58370340d5
https://doi.org/10.1158/1535-7163.22482279.v1
https://doi.org/10.1158/1535-7163.22482279.v1