Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Sylvia A. McCune"'
Autor:
Derek K. Zachman, Adam J. Chicco, Sylvia A. McCune, Robert C. Murphy, Russell L. Moore, Genevieve C. Sparagna
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 3, Pp 525-534 (2010)
Cardiolipin (CL) is an essential phospholipid component of the inner mitochondrial membrane. In the mammalian heart, the functional form of CL is tetralinoleoyl CL [(18:2)4CL]. A decrease in (18:2)4CL content, which is believed to negatively impact m
Externí odkaz:
https://doaj.org/article/f66d6757f9384afab827c0e878fdddec
Autor:
Harjot K. Saini-Chohan, Michael G. Holmes, Adam J. Chicco, William A. Taylor, Russell L. Moore, Sylvia A. McCune, Diane L. Hickson-Bick, Grant M. Hatch, Genevieve C. Sparagna
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 8, Pp 1600-1608 (2009)
Cardiolipin (CL) is responsible for modulation of activities of various enzymes involved in oxidative phosphorylation. Although energy production decreases in heart failure (HF), regulation of cardiolipin during HF development is unknown. Enzymes inv
Externí odkaz:
https://doaj.org/article/7cc5d38a1ac741f3a2a59f388296add9
Autor:
Genevieve C. Sparagna, Adam J. Chicco, Robert C. Murphy, Michael R. Bristow, Christopher A. Johnson, Meredith L. Rees, Melissa L. Maxey, Sylvia A. McCune, Russell L. Moore
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 7, Pp 1559-1570 (2007)
The mitochondrial phospholipid cardiolipin is required for optimal mitochondrial respiration. In this study, cardiolipin molecular species and cytochrome oxidase (COx) activity were studied in interfibrillar (IF) and subsarcolemmal (SSL) cardiac mito
Externí odkaz:
https://doaj.org/article/bfea82e13bcd4da2aa957d45b6be93a4
Autor:
Genevieve C. Sparagna, Chris A. Johnson, Sylvia A. McCune, Russell L. Moore, Robert C. Murphy
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 6, Pp 1196-1204 (2005)
Electrospray ionization mass spectrometry has previously been used to probe qualitative changes in the phospholipid cardiolipin (CL), but it has rarely been used in a quantitative manner. We assessed changes in the amount of individual molecular spec
Externí odkaz:
https://doaj.org/article/57475b9cfab34b109a8cc0d2ce579681
Autor:
Catherine H. Le, Robert C. Murphy, Christopher M. Mulligan, Gerrit J. Bouma, Melissa A. Routh, Michael R. Bristow, Russell L. Moore, Genevieve C. Sparagna, Kimberly M. Jeckel, Sylvia A. McCune, Simona Zarini, Adam J. Chicco, Melinda A. Frye, Joshua M. Lynch
Publikováno v:
Circulation: Heart Failure. 7:172-183
Background— Remodeling of myocardial phospholipids has been reported in various forms of heart failure for decades, but the mechanism and pathophysiological relevance of this phenomenon have remained unclear. We examined the hypothesis that δ-6 de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0846efe3f99ef5b51b974a97576e724
https://doi.org/10.1161/circheartfailure.113.000744
https://doi.org/10.1161/circheartfailure.113.000744
Autor:
Sylvia A. McCune, Qi Wang, Ilze Matise, Lynette K. Rogers, Fred S. Apple, M. Judith Radin, Lois Jane Heller, Leslie C. Sharkey, Anthony H. Tobias
Publikováno v:
Toxicology and Applied Pharmacology. 273:47-57
Life threatening complications from chemotherapy occur frequently in cancer survivors, however little is known about genetic risk factors. We treated male normotensive rats (WKY) and strains with hypertension (SHR) and hypertension with cardiomyopath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d305f67a5bab83b7d0681600f2fbafb
https://doi.org/10.1016/j.taap.2013.08.012
https://doi.org/10.1016/j.taap.2013.08.012
The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity
Autor:
Sylvia A. McCune, Lois Jane Heller, Leslie C. Sharkey, Ilze Matise, Beshay N M Zordoky, Fred S. Apple, M. Judith Radin, Anthony H. Tobias
Publikováno v:
Cardio-Oncology
Background Doxorubicin (DOX) is a very effective anticancer medication that is commonly used to treat hematological malignancies and solid tumors. Nevertheless, DOX is known to have cardiotoxic effects that may lead to cardiac dysfunction and failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e06b5691602d19b7db67510fbd67d1
https://doi.org/10.1186/s40959-016-0013-3
https://doi.org/10.1186/s40959-016-0013-3
Autor:
Timothy A. McKinsey, Sylvia A. McCune, Leslie A. Leinwand, Maria A. Cavasin, David Irwin, Todd R. Horn, Mark Y. Jeong, Douglas D. Lemon, Carlin S. Long, Eunhee Chung, Kurt W. Haubold
Publikováno v:
Journal of Molecular and Cellular Cardiology. 51:41-50
Small molecule histone deacetylase (HDAC) inhibitors block adverse cardiac remodeling in animal models of heart failure. The efficacious compounds target class I, class IIb and, to a lesser extent, class IIa HDACs. It is hypothesized that a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a55748f72369acdd257d13c29d31cc
https://doi.org/10.1016/j.yjmcc.2011.04.005
https://doi.org/10.1016/j.yjmcc.2011.04.005
Autor:
Robert C. Murphy, Sylvia A. McCune, Adam J. Chicco, Derek K. Zachman, Genevieve C. Sparagna, Russell L. Moore
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 3, Pp 525-534 (2010)
Cardiolipin (CL) is an essential phospholipid component of the inner mitochondrial membrane. In the mammalian heart, the functional form of CL is tetralinoleoyl CL [(18:2)(4)CL]. A decrease in (18:2)(4)CL content, which is believed to negatively impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355aa35ede723b5476ef304a38cede43
http://www.sciencedirect.com/science/article/pii/S0022227520305101
http://www.sciencedirect.com/science/article/pii/S0022227520305101
Autor:
William A. Taylor, Grant M. Hatch, Michael Holmes, Diane L. M. Hickson-Bick, Russell L. Moore, Sylvia A. McCune, Genevieve C. Sparagna, Harjot K. Saini-Chohan, Adam J. Chicco
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 8, Pp 1600-1608 (2009)
Cardiolipin (CL) is responsible for modulation of activities of various enzymes involved in oxidative phosphorylation. Although energy production decreases in heart failure (HF), regulation of cardiolipin during HF development is unknown. Enzymes inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d763e5caf54cb3997253f1ba168fb0d5
http://www.sciencedirect.com/science/article/pii/S0022227520307616
http://www.sciencedirect.com/science/article/pii/S0022227520307616