Výsledky vyhledávání - "Sylvia, Urban"

Akademický článek

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer treatment. Recently, we characterised the role of lysine methyltransferase 9 (KMT9) in prostate, lung, and colon cancer. Our observation that the enz

Externí odkaz: https://doaj.org/article/dd0315952e94463cb2a9a88ac996f944

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Akademický článek

Phytochemical Profiling Studies of Alkaloids and Coumarins from the Australian Plant Geijera parviflora Lindl. (Rutaceae) and Their Anthelmintic and Antimicrobial Assessment

Autor: Deepika Dugan, Rachael J. Bell, Robert Brkljača, Colin Rix, Aya C. Taki, Robin B. Gasser, Sylvia Urban

Publikováno v: Metabolites, Vol 14, Iss 5, p 259 (2024)

Phytochemical profiling followed by antimicrobial and anthelmintic activity evaluation of the Australian plant Geijera parviflora, known for its customary use in Indigenous Australian ceremonies and bush medicine, was performed. In the present study,

Externí odkaz: https://doaj.org/article/bb39311c8a654bc1811d510ca44f2446

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Akademický článek

A Review of the Ethnobotanical Use, Chemistry and Pharmacological Activities of Constituents Derived from the Plant Genus Geijera (Rutaceae)

Autor: Deepika Dugan, Rachael J. Bell, Robert Brkljača, Colin Rix, Sylvia Urban

Publikováno v: Metabolites, Vol 14, Iss 2, p 81 (2024)

Geijera Schott is a plant genus of the Rutaceae Juss. (rue and citrus) family, comprising six species which are all native to Oceania. Of the plants belonging to this genus, the most significant species that has a customary use is Geijera parviflora,

Externí odkaz: https://doaj.org/article/aa812abb7c894db291c06ee734c15cc7

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Akademický článek

Targeted Isolation of Antibiotic Brominated Alkaloids from the Marine Sponge Pseudoceratina durissima Using Virtual Screening and Molecular Networking

Autor: James Lever, Florian Kreuder, Jason Henry, Andrew Hung, Pierre-Marie Allard, Robert Brkljača, Colin Rix, Aya C. Taki, Robin B. Gasser, Jan Kaslin, Donald Wlodkowic, Jean-Luc Wolfender, Sylvia Urban

Publikováno v: Marine Drugs, Vol 20, Iss 9, p 554 (2022)

Many targeted natural product isolation approaches rely on the use of pre-existing bioactivity information to inform the strategy used for the isolation of new bioactive compounds. Bioactivity information can be available either in the form of prior

Externí odkaz: https://doaj.org/article/0b365bf039a049018bffc8d219f672c5

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Akademický článek

Application of Networking Approaches to Assess the Chemical Diversity, Biogeography, and Pharmaceutical Potential of Verongiida Natural Products

Autor: James Lever, Robert Brkljača, Colin Rix, Sylvia Urban

Publikováno v: Marine Drugs, Vol 19, Iss 10, p 582 (2021)

This study provides a review of all isolated natural products (NPs) reported for sponges within the order Verongiida (1960 to May 2020) and includes a comprehensive compilation of their geographic and physico-chemical parameters. Physico-chemical par

Externí odkaz: https://doaj.org/article/422db8d9bb294bdc9b3c120eaeb4fb4f

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Akademický článek

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

Autor: Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle

Publikováno v: Cell Reports, Vol 17, Iss 4, Pp 1008-1021 (2016)

Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-sel

Externí odkaz: https://doaj.org/article/15acdfef4129450fb67865a1bd83d169

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Data from KMT9 Controls Stemness and Growth of Colorectal Cancer

Autor: Roland Schüle, Eric Metzger, Rebecca Kesselring, Stefan Fichtner-Feigl, Florian R. Greten, Valentina Petrocelli, Mark Schmitt, Karsten Rippe, Lisa Marx, Stephan M. Tirier, Sylvia Urban, Dominica Willmann, Félicie Cottard, Christopher Berlin

Colorectal cancer is among the leading causes of cancer-associated deaths worldwide. Treatment failure and tumor recurrence due to survival of therapy-resistant cancer stem/initiating cells represent major clinical issues to overcome. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48d5c76e37676e1e58da97cf971dc2e8
https://doi.org/10.1158/0008-5472.c.6513688.v1

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