GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity

Autor: Serena Melgrati, Oliver J. Gerken, Marc Artinger, Egle Radice, Martyna Szpakowska, Andy Chevigné, Giulia D’Uonnolo, Paola Antonello, Sylvia Thelen, Pawel Pelczar, Daniel F. Legler, Marcus Thelen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating

Externí odkaz: https://doaj.org/article/9970cfc4f4c44b67969d20b2bd45a28c

ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production

Autor: Paola Antonello, Diego U. Pizzagalli, Mathilde Foglierini, Serena Melgrati, Egle Radice, Sylvia Thelen, Marcus Thelen

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers. Interfering with this axis by ACKR3 deletion impairs lymphom

Externí odkaz: https://doaj.org/article/82691c7cee7b459e96d494009acf3c8b

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Autor: Jonathan Muri, Valentina Cecchinato, Andrea Cavalli, Akanksha A. Shanbhag, Milos Matkovic, Maira Biggiogero, Pier Andrea Maida, Jacques Moritz, Chiara Toscano, Elaheh Ghovehoud, Raffaello Furlan, Franca Barbic, Antonio Voza, Guendalina De Nadai, Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Lilly A. Murray, Gabriela Danelon-Sargenti, Simone Moro, Tao Gong, Pietro Piffaretti, Filippo Bianchini, Virginia Crivelli, Lucie Podešvová, Mattia Pedotti, David Jarrossay, Jacopo Sgrignani, Sylvia Thelen, Mario Uhr, Enos Bernasconi, Andri Rauch, Antonio Manzo, Adrian Ciurea, Marco B. L. Rocchi, Luca Varani, Bernhard Moser, Barbara Bottazzi, Marcus Thelen, Brian A. Fallon, Onur Boyman, Alberto Mantovani, Christian Garzoni, Alessandra Franzetti-Pellanda, Mariagrazia Uguccioni, Davide F. Robbiani

Publikováno v: Muri, Jonathan; Cecchinato, Valentina; Cavalli, Andrea; Shanbhag, Akanksha A; Matkovic, Milos; Biggiogero, Maira; Maida, Pier Andrea; Moritz, Jacques; Toscano, Chiara; Ghovehoud, Elaheh; Furlan, Raffaello; Barbic, Franca; Voza, Antonio; De Nadai, Guendalina; Cervia, Carlo; Zurbuchen, Yves; Taeschler, Patrick; Murray, Lilly A; Danelon-Sargenti, Gabriela; Moro, Simone; ... (2023). Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course. Nature immunology, 24(4), pp. 604-611. Nature Publishing Group 10.1038/s41590-023-01445-w

Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0f8dec0174a4b1d7107ac5687cdb9f

CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.

Autor: Silvia Volpe, Elisabetta Cameroni, Barbara Moepps, Sylvia Thelen, Tiziana Apuzzo, Marcus Thelen

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37208 (2012)

BACKGROUND: Leukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemot

Externí odkaz: https://doaj.org/article/e06018d2e72944369a04a8ea76a0845c

ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration

Autor: Sabrina Casella, Stefan Dirnhofer, Egle Radice, Sylvia Thelen, Francesco Bertoni, Marcus Thelen, Viola Puddinu

Publikováno v: Oncotarget
Puddinu, Viola; Casella, Sabrina; Radice, Egle; Thelen, Sylvia; Dirnhofer, Stefan; Bertoni, Francesco; Thelen, Marcus (2017). ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration. OncoTarget, 8(49), pp. 85068-85084. Impact Journals LLC 10.18632/oncotarget.18844

Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma accounting for more than the 30% of the cases. Involvement of extranodal sites, such as bone marrow and central nervous system, is associated with poor prognosis. A contribution of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990e90b81f2839cff0ac2e53d223a83b
http://europepmc.org/articles/PMC5689594