Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sylvester Klutchko"'
Autor:
Jean Veith, Barbara W. Henderson, Mel C. Schroeder, Adam B. Sumlin, Denise Driscoll, Paula J. Pera, Wayne D. Klohs, Amarnath Sharma, Sylvester Klutchko, Charles J. Dimitroff, Randall W. Steinkampf, Ralph J. Bernacki, Thomas J. Dougherty
Publikováno v:
Investigational New Drugs. 17:121-135
Angiogenesis, the formation of new blood vessels from an existing vasculature, is requisite for tumor growth. It entails intercellular coordination of endothelial and tumor cells through angiogenic growth factor signaling. Interruption of these event
Autor:
Brian G. Hartl, Randy Steinkampf, T C Major, Joan A. Keiser, Tawny K. Dahring, H. D. Hollis Showalter, Gina H. Lu, Alan J. Kraker, Robert L. Panek, Hussein Hallak, Brian L. Batley, Zhipei Wu, Bill J. Roberts, Sylvester Klutchko, Sandra J. Patmore, William L. Elliott, Laura A. Bradford, Wayne D. Klohs, Annette Marian Doherty, James Marino Hamby, Diane H. Boschelli
Publikováno v:
Journal of Medicinal Chemistry. 41:4365-4377
Screening of a compound library led to the identification of 2-amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine (1) as a inhibitor of the platelet-derived growth factor receptor (PDGFr), fibroblast growth factor receptor (FGFr), and c-src
Autor:
John C. Hodges, Sylvester Klutchko, Quin J rd, James M. Hamby, C. J. C. Connolly, Amy Mae Bunker, Jeremy J. Edmunds, Panek Rl, Ila Sircar, R. T. Winters
Publikováno v:
Journal of Medicinal Chemistry. 38:3759-3771
A series of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins have been prepared and evaluated as in vitro and in vivo angiotensin II (Ang II) antagonists. Variation of substituents on the hydantoin ring leads to potent and selective Ang II a
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:57-62
Syntheses and structure-activity relationships for a series of substituted tetrahydroisoquinoline-3-carboxylic acid derivatives with AT2-specific angiotensin II receptor binding inhibitory activity are reported.
Publikováno v:
Synthetic Communications. 23:971-983
A synthesis of 6-amino-7-cyclohexyl-3,5-heptanediol 1 (CDH) and related amino 1,3-diols involving a nucleophilic ring opening of N-acyl activated lactams is described. Stereochemical proof of the 1,3-diol moiety is also presented.
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 25
Autor:
R. T. Winters, Jeremy J. Edmunds, Joan A. Keiser, Robert L. Panek, C. J. C. Connolly, Amy Mae Bunker, J. Quinn, James Marino Hamby, Sylvester Klutchko, Annette Marian Doherty, Ila Sircar, John C. Hodges
Publikováno v:
ChemInform. 27
Publikováno v:
Journal of Heterocyclic Chemistry. 28:97-108
New derivatives of the naturally occurring amino acid 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (spinacine) are reported. These include amide, ester, 5-alkyl and acyl, and regiospecific N im -alkyl and aralkyl derivatives. Synthe