Výsledky vyhledávání - "Sylvanie Malouitre"

A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

Autor: Henry Dube, Michela Capano, Michela I. Simone, Sylvanie Malouitre, Martin Crompton, David L. Selwood

Publikováno v: Biochemical Journal

Mitochondrial CyP-D (cyclophilin-D) catalyses formation of the PT (permeability transition) pore, a key lesion in the pathogenesis of I/R (ischaemia/reperfusion) injury. There is evidence [Malouitre, Dube, Selwood and Crompton (2010) Biochem. J. 425,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d702d9b47f8e6f29b3290b5e5bfdb276
https://pubmed.ncbi.nlm.nih.gov/22035570

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Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

Autor: David L. Selwood, Sylvanie Malouitre, Martin Crompton, Henry Dube

Publikováno v: Biochemical Journal, 425 (1) pp. 137-148. (2009)
Biochemical Journal

CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2d69f30d30190847179c0a3479a03d
https://discovery.ucl.ac.uk/id/eprint/20029/

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Akademický článek

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation.

Autor: Sylvanie Malouitre, Henry Dube, David Selwood, Martin Crompton

Publikováno v: Biochemical Journal; Dec2009, Vol. 425 Issue 1, p137-148, 12p

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