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of 2
pro vyhledávání: '"Sylvanie D. M. Malouitre"'
Autor:
Hilary R. Glover, Stewart Barker, Sylvanie D. M. Malouitre, John R. Puddefoot, Gavin P. Vinson
Publikováno v:
Pharmaceuticals, Vol 3, Iss 11, Pp 3417-3434 (2010)
Several lines of evidence attest to the existence of alternative ligand binding sites on the oestrogen receptor (ER), including non-competitive inhibition by trilostane or tamoxifen. It is possible that the inhibitory action of conventional oestrogen
Externí odkaz:
https://doaj.org/article/ab678c46693848a89df00f280455cd57
Autor:
John R, Puddefoot, Stewart, Barker, Hilary R, Glover, Sylvanie D M, Malouitre, Gavin P, Vinson
Publikováno v:
International journal of cancer. 101(1)
Currently available antioestrogens, such as tamoxifen, are competitive inhibitors that bind to the ligand binding sites of oestrogen receptors, ERalpha and ERbeta. The search for alternative anti-hormone therapies is prompted by the need for drugs th