Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein

Autor: Sylvaine Lecoeur, Bernadette Videmann, Michèle Mazallon

Publikováno v: Toxicology Letters
Toxicology Letters, Elsevier, 2006, 161 (3), pp.200-209. ⟨10.1016/j.toxlet.2005.09.003⟩

Organophosphate insecticide diazinon is widely used in agricultural practices, submitting farmers to repeated exposure. Because efflux pumps, as P-glycoprotein (P-gp), serve both as natural defense mechanisms and influence the bioavailability and dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b76ab74dbc225a2330855c10d6669e0
https://doi.org/10.1016/j.toxlet.2005.09.003

Diazinon cytotoxicity and transfer in Caco-2 cells: Effect of long-term exposure to the pesticide

Autor: Bernadette Videmann, Sylvaine Lecoeur, Michelle Mazallon, S. Cavret

Publikováno v: Environmental Toxicology and Pharmacology
Environmental Toxicology and Pharmacology, Elsevier, 2005, 20 (2), pp.375-380. ⟨10.1016/j.etap.2005.03.002⟩

International audience; The purpose of this work was to investigate the effect of prolonged exposure to diazinon (widely used organophosphorus pesticide) on the intestinal cell-line Caco-2. Cytotoxicity of the pesticide (50 mu M-6 mM) significantly d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a273d9ee995d3ad734a817492ac0aef
https://doi.org/10.1016/j.etap.2005.03.002

Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis

Autor: Lilia Inoubli, Farah Koraïchi, Nadjem Lakhdari, Aurélie Vega, Mohamed Benahmed, Léo Meunier, Sylvaine Lecoeur, Claire Mauduit, Caroline Prouillac

Publikováno v: Toxicology
Toxicology, Elsevier, 2013, 310, pp.29-38. ⟨10.1016/j.tox.2013.05.002⟩

International audience; Mycotoxin zearalenone (ZEN) is a cereal contaminant produced by various species of Fusarium fungi. When interacting with estrogen receptors, ZEN leads to animal fertility disturbances and other reproductive pathologies. Few da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbf14257a7aba9abd1de17c96c3adda
https://hal.inrae.fr/hal-02644708

Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies

Autor: Sylvaine Lecoeur, Jean-Pierre Flinois, Isabelle de Waziers, José Cosme, Susan Baird, C Belloc, Philippe Beaune, Dominique Challine, Jean-Charles Gautier

Publikováno v: Toxicology. 106:207-219

Cytochromes P450 (CYP) constitute a superfamily of enzymes involved in the metabolism of xenobiotics. Within the same subfamily, the isoforms present strong similarities, making them difficult to characterize and differentiate. Using heterologous exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d4084dc85bd6e80fe230f809988607
https://doi.org/10.1016/0300-483x(95)03178-i

The role of the placenta in fetal exposure to xenobiotics: importance of membrane transporters and human models for transfer studies

Autor: Sylvaine Lecoeur, Caroline Prouillac

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 38(10)

The placenta is a key organ in fetal growth and development because it controls maternal-to-fetal exchanges of nutrients and hormones. It also interferes with drug delivery to the fetus by expressing active membrane transporters and xenobiotic metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b3a078f832cd62569ac8e88a519b13
https://pubmed.ncbi.nlm.nih.gov/20606001