Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sylvain W Lapan"'
Autor:
Melanie Issigonis, Akshada B Redkar, Tania Rozario, Umair W Khan, Rosa Mejia-Sanchez, Sylvain W Lapan, Peter W Reddien, Phillip A Newmark
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001472 (2022)
Sexually reproducing animals segregate their germline from their soma. In addition to gamete-producing gonads, planarian and parasitic flatworm reproduction relies on yolk cell-generating accessory reproductive organs (vitellaria) supporting developm
Externí odkaz:
https://doaj.org/article/b782261626db44e78acdf304854ec834
Autor:
Ryoji Amamoto, Mauricio D Garcia, Emma R West, Jiho Choi, Sylvain W Lapan, Elizabeth A Lane, Norbert Perrimon, Constance L Cepko
Publikováno v:
eLife, Vol 8 (2019)
Recent transcriptional profiling technologies are uncovering previously-undefined cell populations and molecular markers at an unprecedented pace. While single cell RNA (scRNA) sequencing is an attractive approach for unbiased transcriptional profili
Externí odkaz:
https://doaj.org/article/9026574e8ffd44f28611f6f67c62f112
Publikováno v:
eLife, Vol 5 (2016)
Hedgehog signaling is critical for vertebrate central nervous system (CNS) development, but its role in CNS biology in other organisms is poorly characterized. In the planarian Schmidtea mediterranea, hedgehog (hh) is expressed in medial cephalic gan
Externí odkaz:
https://doaj.org/article/87c98ee316ec432c96a73497b0fcf19e
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1003999 (2014)
Planarian regeneration requires positional information to specify the identity of tissues to be replaced as well as pluripotent neoblasts capable of differentiating into new cell types. We found that wounding elicits rapid expression of a gene encodi
Externí odkaz:
https://doaj.org/article/0de535a53004446cb8cdce7534aa2879
Autor:
Sylvain W Lapan, Peter W Reddien
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002226 (2011)
Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation and regeneration. We identifi
Externí odkaz:
https://doaj.org/article/3be544472ef842ce9558dc89c32c0d54
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 376-386 (2020)
Gene therapy with recombinant adeno-associated viral (AAV) vectors is a promising modality for the treatment of a variety of human diseases. Nonetheless, there remain significant gaps in our understanding of AAV vector biology, due in part to the lac
Externí odkaz:
https://doaj.org/article/a01a18cf1729403a9a933268be62fc27
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 339-352 (2014)
Planarians can regenerate any missing body part in a process requiring dividing cells called neoblasts. Historically, neoblasts have largely been considered a homogeneous stem cell population. Most studies, however, analyzed neoblasts at the populati
Externí odkaz:
https://doaj.org/article/8f262dec8e8c49f4b7a3a72304825bb8
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 376-386 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Gene therapy with recombinant adeno-associated viral (AAV) vectors is a promising modality for the treatment of a variety of human diseases. Nonetheless, there remain significant gaps in our understanding of AAV vector biology, due in part to the lac
Autor:
Akshada Redkar, Rosa Mejia-Sanchez, Sylvain W. Lapan, Peter W. Reddien, Umair W. Khan, Tania Rozario, Melanie Issigonis, Phillip A. Newmark
Sexually reproducing animals segregate their germline from their soma. In addition to gamete-producing gonads, planarian and parasitic flatworm reproduction relies on yolk-cell-generating accessory reproductive organs (vitellaria) supporting developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb1a3c40d28253e7264726c17024a79
https://doi.org/10.1101/2021.11.08.467675
https://doi.org/10.1101/2021.11.08.467675
Autor:
Sinem K. Saka, Jocelyn Y. Kishi, Edward S. Boyden, Yu Wang, George M. Church, Allen Zhu, Clarence Yapp, Koray Kirli, Wenxin Xie, German Pihan, Sylvain W. Lapan, Pascal S. Kaeser, Peng Yin, Brian J. Beliveau, Yitian Zeng, Marcelo Cicconet, Siyuan Yin, Millicent Lin
Publikováno v:
Nature biotechnology
PMC
PMC
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity and throughput. Here we report immunostaining with signal amplification by