Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sylvain Huard"'
Autor:
Elizabeth A Walden, Roger Y Fong, Trang T Pham, Hana Knill, Sarah Jane Laframboise, Sylvain Huard, Mary-Ellen Harper, Kristin Baetz
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009220 (2020)
Cellular metabolism is tightly regulated by many signaling pathways and processes, including lysine acetylation of proteins. While lysine acetylation of metabolic enzymes can directly influence enzyme activity, there is growing evidence that lysine a
Externí odkaz:
https://doaj.org/article/7aaf5f105fb142c8a4a4c97aed7e0c45
Autor:
Meaghen Rollins, Sylvain Huard, Alan Morettin, Jennifer Takuski, Trang Thuy Pham, Morgan D Fullerton, Jocelyn Côté, Kristin Baetz
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006626 (2017)
Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is require
Externí odkaz:
https://doaj.org/article/96a1eee42e0d4eae868d2f2d0c859d79
Publikováno v:
Genetics. 221
Acetyl-CoA Carboxylase 1 catalyzes the conversion of acetyl-CoA to malonyl-CoA, the committed step of de novo fatty acid synthesis. As a master regulator of lipid synthesis, acetyl-CoA carboxylase 1 has been proposed to be a therapeutic target for nu
Autor:
Alexander R. Pelletier, Viyashini Vijithakumar, Sabrina Robichaud, Sylvain Huard, Mathieu Lavallée-Adam, Daniel Figeys, David P. Cook, Barbara C. Vanderhyden, Garrett Fairman, Mireille Ouimet, Esther Mak, Kristin Baetz
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy relies on tags such as ubiquitin and a set of selectivity factors inc
Publikováno v:
Journal of Biological Chemistry. 299:102834
Under environmental stress, such as glucose deprivation, cells form stress granules - the accumulation of cytoplasmic aggregates of repressed translational initiation complexes, proteins, and stalled mRNAs. Recent research implicates stress granules
Autor:
Hana Knill, Mary-Ellen Harper, Kristin Baetz, Trang Thuy Pham, Sarah Jane Laframboise, Sylvain Huard, Roger Y. Fong, Elizabeth A. Walden
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009220 (2020)
PLoS Genetics
PLoS Genetics
Cellular metabolism is tightly regulated by many signaling pathways and processes, including lysine acetylation of proteins. While lysine acetylation of metabolic enzymes can directly influence enzyme activity, there is growing evidence that lysine a
Autor:
Morgan D. Fullerton, Jocelyn Côté, Sylvain Huard, Alan Morettin, Kristin Baetz, Trang Thuy Pham, Meaghen Rollins, Jennifer Takuski
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 2, p e1006626 (2017)
PLoS Genetics, Vol 13, Iss 2, p e1006626 (2017)
Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is require
Publikováno v:
Journal of Cellular Biochemistry. 96:1071-1085
c-Myc transcriptional activity in cells is dampened by the Mad family of transcriptional repressors. The expression of one member, hMad4, is increased in growth-arrested states such as quiescence or replicative senescence; hMad4 mRNA levels in replic
Autor:
Chantal Autexier, Sylvain Huard
Publikováno v:
Nucleic Acids Research. 32:2171-2180
Telomerase is a reverse transcriptase that uses an integral RNA molecule to add de novo G-rich repeats onto telomeric DNA, or onto nontelomeric DNA generated during chromosome fragmentation and breakage events. A telomerase-mediated DNA substrate cle
The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity
Publikováno v:
Nucleic Acids Research. 31:4059-4070
The catalytic subunit of telomerase (TERT) contains conserved reverse transcriptase-like motifs but N- and C-terminal regions unique to telomerases. Despite weak sequence conservation, the C terminus of TERTs from various organisms has been implicate