Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sylvain Huard"'
Autor:
Elizabeth A Walden, Roger Y Fong, Trang T Pham, Hana Knill, Sarah Jane Laframboise, Sylvain Huard, Mary-Ellen Harper, Kristin Baetz
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009220 (2020)
Cellular metabolism is tightly regulated by many signaling pathways and processes, including lysine acetylation of proteins. While lysine acetylation of metabolic enzymes can directly influence enzyme activity, there is growing evidence that lysine a
Externí odkaz:
https://doaj.org/article/7aaf5f105fb142c8a4a4c97aed7e0c45
Autor:
Meaghen Rollins, Sylvain Huard, Alan Morettin, Jennifer Takuski, Trang Thuy Pham, Morgan D Fullerton, Jocelyn Côté, Kristin Baetz
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006626 (2017)
Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is require
Externí odkaz:
https://doaj.org/article/96a1eee42e0d4eae868d2f2d0c859d79
Publikováno v:
Journal of Biological Chemistry. 299:102834
Under environmental stress, such as glucose deprivation, cells form stress granules - the accumulation of cytoplasmic aggregates of repressed translational initiation complexes, proteins, and stalled mRNAs. Recent research implicates stress granules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbf938b61c88a85c7352081a59e2d25
https://doi.org/10.1016/j.jbc.2022.102834
https://doi.org/10.1016/j.jbc.2022.102834
Autor:
Morgan D. Fullerton, Jocelyn Côté, Sylvain Huard, Alan Morettin, Kristin Baetz, Trang Thuy Pham, Meaghen Rollins, Jennifer Takuski
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 2, p e1006626 (2017)
PLoS Genetics, Vol 13, Iss 2, p e1006626 (2017)
Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de43830e0ef400722a42e5662fe36991
https://pubmed.ncbi.nlm.nih.gov/28231279
https://pubmed.ncbi.nlm.nih.gov/28231279
Publikováno v:
Journal of Cellular Biochemistry. 96:1071-1085
c-Myc transcriptional activity in cells is dampened by the Mad family of transcriptional repressors. The expression of one member, hMad4, is increased in growth-arrested states such as quiescence or replicative senescence; hMad4 mRNA levels in replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17951814bd1a6aa93e7ec5884c2d6c0a
https://doi.org/10.1002/jcb.20503
https://doi.org/10.1002/jcb.20503
The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity
Publikováno v:
Nucleic Acids Research. 31:4059-4070
The catalytic subunit of telomerase (TERT) contains conserved reverse transcriptase-like motifs but N- and C-terminal regions unique to telomerases. Despite weak sequence conservation, the C terminus of TERTs from various organisms has been implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e853b4f245a46ae29f07d9bb0f63b9ff
https://doi.org/10.1093/nar/gkg437
https://doi.org/10.1093/nar/gkg437
Autor:
Sylvain Huard, Chantal Autexier
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 2:577-587
Telomerase is a specialized RNA template-containing reverse transcriptase that mediates telomere repeat synthesis at chromosome ends. The maintenance of telomere length and integrity is essential for cell survival. Telomerase is active in most immort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c618f6b6517338337e2f12836cd310b5
https://doi.org/10.2174/1568011023353822
https://doi.org/10.2174/1568011023353822
Publikováno v:
Molecular and Cellular Biology. 22:1253-1265
Functional human telomerase complexes are minimally composed of the human telomerase RNA (hTR) and a catalytic subunit (human telomerase reverse transcriptase [hTERT]) containing reverse transcriptase (RT)-like motifs. The N terminus of TERT proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eec655464a311dfd5668aacf087920
https://doi.org/10.1128/mcb.22.4.1253-1265.2002
https://doi.org/10.1128/mcb.22.4.1253-1265.2002
Autor:
Kristin Baetz, Sylvain Huard, Daniel A. Figeys, Anne-Lise Steunou, Hu Zhou, Jacques Côté, Zhibin Ning, Roghayeh Pourhanifeh-Lemeri, Leslie A. Mitchell, Akil Hamza, Amrita Basu, Jean-Philippe Lambert, Michael Cotrut
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Recent global proteomic and genomic studies have determined that lysine acetylation is a highly abundant posttranslational modification. The next challenge is connecting lysine acetyltransferases (KATs) to their cellular targets. We hypothesize that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecfa932fcc675280a51ccd11d1fbc6e
https://doi.org/10.1073/pnas.1218515110
https://doi.org/10.1073/pnas.1218515110
Autor:
Min Yu, Kristen E Burdette, Csaba Fenyvuesvolgyi, Robert T. Elder, Sylvain Huard, Mingzhong Chen, Richard Y. Zhao
Publikováno v:
Cell research. 18(9)
Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell death in mammalian and fission yeast cells, suggesting that Vpr may affect a conserved cellular process. It is unclear, however, whether Vpr-induced yeast cell death mimics Vpr-mediated apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e140605f5a8ccd96a1f0b6d2a172d6c1
https://pubmed.ncbi.nlm.nih.gov/19160543
https://pubmed.ncbi.nlm.nih.gov/19160543