Výsledky vyhledávání - "Sylvain Gauthier"

SIFT-ONN: SIFT Feature Detection Algorithm Employing ONNs for Edge Detection

Autor: Madeleine Abernot, Sylvain Gauthier, Theophile Gonos, Aida Todri-Sanial

Publikováno v: NICE 2023-Neuro-Inspired Computational Elements Workshop
NICE 2023-Neuro-Inspired Computational Elements Workshop, Apr 2023, San Antonio, TX, United States. ⟨10.1145/3584954.3584999⟩
Proceedings of the 2023 Annual Neuro-Inspired Computational Elements Conference, NICE 2023, 100-107
STARTPAGE=100;ENDPAGE=107;TITLE=Proceedings of the 2023 Annual Neuro-Inspired Computational Elements Conference, NICE 2023

International audience; Mobile robot navigation tasks can be applied in various domains, such as in space, underwater, and transportation industries, among others. In navigation, robots analyze their environment from sensors and navigate safely up to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89371f6acada1b8c65a0850ecaaa721f
https://doi.org/10.1145/3584954.3584999

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Steroid derivatives as pure antagonists of the androgen receptor

Autor: Céline Martel, Fernand Labrie, Sylvain Gauthier

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 132:93-104

Background While the androgens of testicular origin (representing about 50% of total androgens in men over 50 years) can be completely eliminated by surgical or medical castration with GnRH (gonadotropin-releasing hormone) agonists or antagonists, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72ae1a16da9e949ee3e8c41cfa73742
https://doi.org/10.1016/j.jsbmb.2012.02.006

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Synthesis and deuterium labelling of the pure selective estrogen receptor modulator (SERM) acolbifene glucuronides

Autor: Agnès Coquet, Jean-Yves Sancéau, Fernand Labrie, Denis Larouche, Patrick Bélanger, Alain Bélanger, Brigitte Caron, Sylvain Gauthier

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 50:197-206

Acolbifene (EM-652·HCl, SCH 57068·HCl), a highly potent and orally active selective estrogen receptor modulator (SERM), is at late stage clinical development for the treatment of estrogen-sensitive breast cancer. Acolbifene-7-glucuronide 1 (major)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7a9e37c98b11c76710c126dbb3da3c3
https://doi.org/10.1002/jlcr.1260

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Synthesis and structure–activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution

Autor: Alexandre Favre, Yves Merand, Jacques Simard, Carl Ouellet, Yves L. Dory, Céline Martel, Fernand Labrie, Julie Cloutier, Annette Schwerdtfeger, Sylvain Gauthier, Josée Mailhot

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry. 20:165-177

EM-652 (acolbifene) analogs have been synthesized as selective estrogen receptor modulators. Substitution on the nitrogen atom of these 2H-1-benzopyran derivatives has been studied for its influence on antiestrogenic activity. Binding to the rat estr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818900bd5bbbce7753506bc893628275
https://doi.org/10.1080/14756360500043448

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Synthesis of14C-labelled EM-800(SCH 57050) and EM-652·HCl(SCH 57068·HCl, acolbifene), pure selective estrogen receptor modulators

Autor: Fernand Labrie, Jean-Yves Sancéau, Sylvain Gauthier

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 47:741-752

EM-800 (SCH 57050) and EM-652·HCl (SCH 57068·HCl, acolbifene) are orally active pure selective estrogen receptor modulators. The corresponding 14C2-radiolabelled compounds 1 and 2 were synthesized for metabolic studies with uniform labelling of two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0abc8a7a2f8097ecb70cb1f565670877
https://doi.org/10.1002/jlcr.862

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Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships

Autor: Fernand Labrie, Shankar M. Singh, Sylvain Gauthier

Publikováno v: Current Medicinal Chemistry. 7:211-247

Prostate cancer, acne, seborrhea, hirsutism, and androgenic alopecia are well recognized to depend upon an excess or increased sensitivity to androgens or to be at least sensitive to androgens. It thus seems logical to use antiandrogens as therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d037e4f39deaffdfa40f9fb49b2d7756
https://doi.org/10.2174/0929867003375371

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New Highly Stereoselective Synthesis of (E)-Droloxifene via Selective Protection of 3,4′-Dihydroxybenzophenone and McMurry Reaction

Autor: Sylvain Gauthier, Josée Mailhot, Brigitte Caron, Julie Cloutier, Jean-Yves Sancéau

Publikováno v: Tetrahedron. 56:703-709

A new, highly stereoselective synthesis of ( E )-droloxifene is reported. Deprotection of 3,4′-dimethoxybenzophenone and selective pivaloylation of the 3′-phenolic position gave 4-hydroxy-3′-(trimethylacetoxy)benzophenone. A McMurry reaction be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fd5b1a06b2726cc5e0c90425699259b
https://doi.org/10.1016/s0040-4020(99)01061-3

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EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 69:51-84

Breast cancer is the most frequent cancer in women while it is the second cause of cancer death. Estrogens are well recognized to play the predominant role in breast cancer development and growth and much efforts have been devoted to the blockade of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb179f6f5da68c9d8298c9bfe07cd66f
https://doi.org/10.1016/s0960-0760(99)00065-5

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Effect of Twenty-Four-Week Treatment with the Antiestrogen EM-800 on Estrogen-Sensitive Parameters in Intact and Ovariectomized Mice

Autor: Shouqi Luo, Claude Labrie, Alain Bélanger, Fernand Labrie, Antigone Sourla, Yves Merand, Sylvain Gauthier

Publikováno v: Endocrinology. 139:2645-2656

Treatment with the antiestrogen EM-800, at the daily oral dose of 3μ g, 10 μg, 30 μg, or 100 μg for 24 weeks, caused a marked inhibition of uterine and vaginal weight in both intact and ovariectomized mice. Maximal 64% and 41% inhibitions of uter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a30da4fd41b56d0575065a3b4942c2
https://doi.org/10.1210/endo.139.5.5994

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Binding characteristics of novel nonsteroidal antiestrogens to the rat uterine estrogen receptors

Autor: Céline Martel, Fernand Labrie, Yves Merand, Sylvain Gauthier, Gilles Leblanc, Alain St. Pierre, Louis Provencher, Xun Li

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 64:199-205

Tamoxifen (TAM), the only antiestrogen currently available for the endocrine therapy of breast cancer behaves as a mixed agonist/antagonist of estrogen action, thus limiting its therapeutic potential. We report the binding characteristics of a novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc7bcafda5670c7161b360f02ad2368
https://doi.org/10.1016/s0960-0760(97)00192-1

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