Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sylvain Galvani"'
Autor:
Raphael Devillard, Sylvain Galvani, Jean-Claude Thiers, Jean-Louis Guenet, Yusuf Hannun, Jacek Bielawski, Anne Nègre-Salvayre, Robert Salvayre, Nathalie Augé
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9826 (2010)
BACKGROUND:Sphingomyelin hydrolysis in response to stress-inducing agents, and subsequent ceramide generation, are implicated in various cellular responses, including apoptosis, inflammation and proliferation, depending on the nature of the different
Externí odkaz:
https://doaj.org/article/72da290cfec14bdcb5aef7590e870c74
Autor:
Steven Swendeman, Daniel Lin, Shihui Guo, Alan Culbertson, Andrew Kuo, Michel Levesque, Andreane Cartier, Takahiro Seno, Alec Schmaier, Sylvain Galvani, Asuka Inoue, Samir Parikh, Garret A. FitzGerald, Maofu Liao, Robert Flaumenhaft, Timothy Hla
High-density lipoprotein (HDL) particles suppress inflammation-induced tissue injury via vascular and myeloid cell-dependent mechanisms. As such, HDL-associated bioactive lipids such as sphingosine 1-phosphate (S1P) and prostacyclin (PGI2) signal via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4005c5cbaf5588791118de103b09a16
https://doi.org/10.1101/2022.02.14.480375
https://doi.org/10.1101/2022.02.14.480375
Autor:
Koki Kawakami, Junken Aoki, Andreane Cartier, Andrew Kuo, Wenji Piao, Yanbao Xiong, Keisuke Yanagida, Satoru Ishida, Timothy Hla, Jonathan S. Bromberg, Sylvain Galvani, Yu Hisano, Mari Kono, Asuka Inoue, Richard L. Proia, Yuki Ono, Kuniyuki Kano, Eric Engelbrecht
Publikováno v:
The Journal of Experimental Medicine
Sphingosine 1-phosphate receptor-1 signaling via the Gi pathway is suppressed by lysophosphatidic acid receptor-1, which recruits β-arrestin to the heterotypic receptor complex. This mechanism occurs at sinus lining lymphatic endothelial cells of ly
Autor:
Sylvain Galvani, Josef Anrather, Keisuke Yanagida, Costantino Iadecola, Catherine H. Liu, Teresa Sanchez, Giuseppe Faraco, Timothy Hla, Nathalie Burg, Helen K. Smith
Publikováno v:
Proceedings of the National Academy of Sciences. 114:4531-4536
The vasculature of the central nervous system (CNS) forms a selective barrier termed the blood-brain barrier (BBB). Disruption of the BBB may contribute to various CNS diseases. Conversely, the intact BBB restricts efficient penetration of CNS-target
Autor:
Koki Kawakami, Junken Aoki, Andrew Kuo, Eric Engelbrecht, Keisuke Yanagida, Satoru Ishida, Andreane Cartier, Yuki Ono, Timothy Hla, Mari Kono, Asuka Inoue, Richard L. Proia, Sylvain Galvani, Yu Hisano
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) activate G protein-coupled receptors (GPCRs) to regulate key pathobiological processes. Here we report a novel lipid mediator GPCR cross-talk mechanism that modulates lymphatic endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b43c71144a8d9c83e6cb72dc7dacf6d
Autor:
Frank J. Giordano, Hideru Obinata, Timothy Hla, Sylvain Galvani, Yi Zhang, Annarita Di Lorenzo, Milankumar Kothiya, Xian-Cheng Jiang, Mariarosaria Bucci, Anna Cantalupo
Publikováno v:
Nature Medicine. 21:1028-1037
Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly underst
Autor:
Hideru Obinata, Anna Cantalupo, Annarita Di Lorenzo, Sylvain Galvani, Nathalie Burg, Keisuke Yanagida, Catherine H. Liu, Steven L. Swendeman, Timothy Hla, Teresa Sanchez, Hui Yuan, Yi Zhang, Victoria A. Blaho, Eric Engelbrecht, Andreane Cartier, Yu Hisano, Yuquan Xiong, Jane E. Salmon
Publikováno v:
Science signaling. 10(492)
Endothelial dysfunction, a hallmark of vascular disease, is restored by plasma high-density lipoprotein (HDL). However, a generalized increase in HDL abundance is not beneficial, suggesting that specific HDL species mediate protective effects. Apolip
Autor:
Isabelle Castan-Laurell, Bernard Masri, Estelle Wanecq, Yassine Sakar, Cédric Dray, Sylvain Galvani, Philippe Valet, Larry S. Barak, Anne Nègre-Salvayre, Robert Ducroc, Luc Garrigues, Danièle Daviaud, Bernard Monsarrat, Odile Burlet-Schiltz, Claire Vinel
Publikováno v:
Gastroenterology
Gastroenterology, WB Saunders, 2013, 144 (4), pp.771-80. ⟨10.1053/j.gastro.2013.01.004⟩
Gastroenterology, WB Saunders, 2013, 144 (4), pp.771-780. ⟨10.1053/j.gastro.2013.01.004⟩
Gastroenterology, WB Saunders, 2013, 144 (4), pp.771-80. ⟨10.1053/j.gastro.2013.01.004⟩
Gastroenterology, WB Saunders, 2013, 144 (4), pp.771-780. ⟨10.1053/j.gastro.2013.01.004⟩
International audience; BACKGROUND & AIMS: Glucose is absorbed into intestine cells via the sodium glucose transporter 1 (SGLT-1) and glucose transporter 2 (GLUT2); various peptides and hormones control this process. Apelin is a peptide that regulate
Publikováno v:
The Journal of Experimental Medicine
Hla et al. highlight the multitude of biological functions of S1P with a focus on its recently identified role in thrombopoiesis.
Recent work has highlighted the multitude of biological functions of sphingosine 1-phosphate (S1P), which include r
Recent work has highlighted the multitude of biological functions of sphingosine 1-phosphate (S1P), which include r
Autor:
Timothy Hla, Sylvain Galvani
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37:1018-1019
High-density lipoprotein (HDL) particles are characterized by their heterogeneity in composition, structure, and biological properties. In addition to the major structural protein apolipoprotein A1, HDL proteomes and lipidomes show great diversity.1,