Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Sylvain Feliciangeli"'
Autor:
Franck C. Chatelain, Nicolas Gilbert, Delphine Bichet, Annaïse Jauch, Sylvain Feliciangeli, Florian Lesage, Olivier Bignucolo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Highly selective for K+ at neutral pH, the TWIK1 channel becomes permeable to Na+ upon acidification. Using molecular dynamics simulations, we identify a network of residues involved in this unique property. Between the open and closed state
Externí odkaz:
https://doaj.org/article/014500923e1e431389b15c7a56c2aa1e
Autor:
Barbara B. R. Oliveira‐Mendes, Malak Alameh, Jérôme Montnach, Béatrice Ollivier, Solène Gibaud, Sylvain Feliciangeli, Florian Lesage, Flavien Charpentier, Gildas Loussouarn, Michel De Waard, Isabelle Baró
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/40978472905f4000b05d8795faddb34a
Autor:
Frank S. Choveau, Ismail Ben Soussia, Delphine Bichet, Franck C. Chatelain, Sylvain Feliciangeli, Florian Lesage
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/891b8670092a439983df64c08e0023d9
Autor:
Barbara Oliveira‐Mendes, Sylvain Feliciangeli, Mélissa Ménard, Frank Chatelain, Malak Alameh, Jérôme Montnach, Sébastien Nicolas, Béatrice Ollivier, Julien Barc, Isabelle Baró, Jean‐Jacques Schott, Vincent Probst, Florence Kyndt, Isabelle Denjoy, Florian Lesage, Gildas Loussouarn, Michel De Waard
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
Abstract Background and aims Mutations in KCNH2 cause long or short QT syndromes (LQTS or SQTS) predisposing to life‐threatening arrhythmias. Over 1000 hERG variants have been described by clinicians, but most remain to be characterised. The object
Externí odkaz:
https://doaj.org/article/acbf1713166b446c8093329363ed25ac
Autor:
Frank S Choveau, Ismail Ben Soussia, Delphine Bichet, Chatelain C. Franck, Sylvain Feliciangeli, Florian Lesage
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH. How these signals affect the gating of these channels is the subject of intense
Externí odkaz:
https://doaj.org/article/07d33a38848c4d0183ced9c73c1ad2aa
Autor:
Nicole Bobak, Sylvain Feliciangeli, Cheng-Chang Chen, Ismail Ben Soussia, Stefan Bittner, Sophie Pagnotta, Tobias Ruck, Martin Biel, Christian Wahl-Schott, Christian Grimm, Sven G. Meuth, Florian Lesage
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Recombinant TWIK2 channels produce weak basal background K+ currents. Current amplitudes depend on the animal species the channels have been isolated from and on the heterologous system used for their re-expression. Here we show that this va
Externí odkaz:
https://doaj.org/article/c08363747f7a45328c794c87466f64ca
Autor:
Ismail Ben Soussia, Frank S. Choveau, Sandy Blin, Eun-Jin Kim, Sylvain Feliciangeli, Franck C. Chatelain, Dawon Kang, Delphine Bichet, Florian Lesage
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
TREK/TRAAK channels are polymodal K+ channels that convert very diverse stimuli, including bioactive lipids, mechanical stretch and temperature, into electrical signals. The nature of the structural changes that regulate their activity remains an ope
Externí odkaz:
https://doaj.org/article/67683d0d8ef84390be2c9f1f6e496be8
Autor:
Nina Milosavljevic, Michaël Monet, Isabelle Léna, Frédéric Brau, Sandra Lacas-Gervais, Sylvain Feliciangeli, Laurent Counillon, Mallorie Poët
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 689-696 (2014)
Vesicular H+-ATPases and ClC-chloride transporters are described to acidify intracellular compartments, which also express the highly conserved Na+/H+ exchangers NHE6, NHE7, and NHE9. Mutations of these exchangers cause autism-spectrum disorders and
Externí odkaz:
https://doaj.org/article/5ed5e3d9e4a14ff6887a40dbb4eb51a3
Autor:
Dawon Kang, Florian Lesage, Lamyaa Khoubza, Sylvain Feliciangeli, Eun-Jin Kim, Delphine Bichet, Franck C. Chatelain
Two-pore domain (K2P) potassium channels are active as dimers. They produce inhibitory currents regulated by a variety of stimuli. Among them, TALK1, TALK2 and TASK2 form a subfamily of structurally related K2P channels stimulated by extracellular al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90e3516615c85a5be2bfe0737e7749d
https://doi.org/10.1101/2021.11.08.467666
https://doi.org/10.1101/2021.11.08.467666
Autor:
Julien Barc, Béatrice Ollivier, Sylvain Feliciangeli, Malak Alameh, Vincent Probst, Isabelle Denjoy, Barbara Oliveira-Mendes, Jean-Jacques Schott, Frank Chatelain, S. Nicolas, Florian Lesage, Jérôme Montnach, Isabelle Baró, Michel De Waard, F. Kyndt, Mélissa Ménard, Gildas Loussouarn
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
Clinical and Translational Medicine
Clinical and Translational Medicine, 2021, 11 (11), pp.100355. ⟨10.1002/ctm2.609⟩
Clinical and Translational Medicine, 2021, 11 (11), ⟨10.1002/ctm2.609⟩
Clinical and Translational Medicine
Clinical and Translational Medicine, 2021, 11 (11), pp.100355. ⟨10.1002/ctm2.609⟩
Clinical and Translational Medicine, 2021, 11 (11), ⟨10.1002/ctm2.609⟩
Background and aims Mutations in KCNH2 cause long or short QT syndromes (LQTS or SQTS) predisposing to life‐threatening arrhythmias. Over 1000 hERG variants have been described by clinicians, but most remain to be characterised. The objective is to