The BlueScreen HC assay to predict the genotoxic potential of fragrance materials

Autor: Yax Thakkar, Kaushal Joshi, Christina Hickey, Joseph Wahler, Brian Wall, Sylvain Etter, Benjamin Smith, Peter Griem, Matthew Tate, Frank Jones, Gladys Oudraogo, Stefan Pfuhler, Christopher Choi, Gary Williams, Helmut Greim, Gerhard Eisenbrand, Wolfgang Dekant, Anne Marie Api

Publikováno v: Mutagenesis. 37:13-23

BlueScreen HC is a mammalian cell-based assay for measuring the genotoxicity and cytotoxicity of chemical compounds and mixtures. The BlueScreen HC assay has been utilized at the Research Institute for Fragrance Materials in a safety assessment progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5697c94e4aad4a6a10d085f462fd1cb5
https://doi.org/10.1093/mutage/geac004

In ovo testing of flavor and fragrance materials in Turkey Egg Genotoxicity Assay (TEGA), comparison of results to in vitro and in vivo data

Autor: B. Smith, Jian-Dong Duan, Sylvain Etter, Gary M. Williams, Tetyana Kobets, Michael J. Iatropoulos, Christina Hickey, Klaus D. Brunnemann

Publikováno v: Food and Chemical Toxicology. 115:228-243

Genotoxicity of flavor and fragrance materials was assessed in Turkey Egg Genotoxicity Assay (TEGA) using 32P-nucleotide postlabeling (NPL) and comet assays to detect hepatic DNA adducts and strand breaks. Twenty materials having results in GADD45a-G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df798dcaacde9bd94ec66f1494ed2fba
https://doi.org/10.1016/j.fct.2018.03.015

2,4-Decadienal does not induce genotoxic effects in in vivo micronucleus studies

Autor: Kevin J. Renskers, Christie L. Harman, Gerhard Krammer, Sylvain Etter, Maria Bastaki, Jan Demyttenaere, Maodo Malick Diop, Sean V. Taylor, Jürgen Schnabel, Xing Han, Shim-mo Hayashi, Thierry Cachet, Vivian Lu, Zena Keig-Shevlin, Michel Aubanel

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis. 846

2,4-Decadienal (E,E-) occurs naturally in foods and is also used as a flavoring ingredient. In vivo micronucleus studies were used to evaluate the potential for 2,4-decadienal to cause genotoxic effects. Male Han Wistar rats were dosed either by intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8cac3d914c53e2f9238cb3d536ca3f
https://pubmed.ncbi.nlm.nih.gov/31585634

A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert-derived structure-activity alert spaces

Autor: Steven J, Canipa, Martyn L, Chilton, Rachel, Hemingway, Donna S, Macmillan, Alun, Myden, Jeffrey P, Plante, Rachael E, Tennant, Jonathan D, Vessey, Thomas, Steger-Hartmann, Janet, Gould, Jedd, Hillegass, Sylvain, Etter, Benjamin P C, Smith, Angela, White, Paul, Sterchele, Ann, De Smedt, Devin, O'Brien, Rahul, Parakhia

Publikováno v: Journal of applied toxicology : JAT. 37(8)

Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb6b994eafdb2f3099447f035ba1c46c
https://pubmed.ncbi.nlm.nih.gov/28244128

The 'BlueScreen HC' assay as a decision making test in the genotoxicity assessment of flavour and fragrance materials

Autor: Richard M. Walmsley, Louise Birrell, Nicholas Billinton, Heather Scott, Sylvain Etter, P. A. Cahill, B. Smith

Publikováno v: Etter, S, Birrell, L, Cahill, P, Scott, H S, Billinton, N, Walmsley, R M & Smith, B 2015, ' The 'BlueScreen HC' assay as a decision making test in the genotoxicity assessment of flavour and fragrance materials ', Toxicology in Vitro, vol. 29, no. 7, pp. 1425-1435 . https://doi.org/10.1016/j.tiv.2015.05.005

The genotoxicity of a library of 70 flavour and fragrance substances having a high proportion of in vivo and/or carcinogenicity test data has been assessed using the GADD45a-GLuc ‘BlueScreen HC’ genotoxicity assay, with and without exogenous meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac146a05207993c06ed621b43599448
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:265079