Výsledky vyhledávání - "Sylvain Egloff"

Akademický článek

The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

Autor: Cécilia Studniarek, Michael Tellier, Pascal G.P. Martin, Shona Murphy, Tamás Kiss, Sylvain Egloff

Publikováno v: Cell Reports, Vol 35, Iss 2, Pp 108965- (2021)

Summary: Conversion of promoter-proximally paused RNA polymerase II (RNAPII) into elongating polymerase by the positive transcription elongation factor b (P-TEFb) is a central regulatory step of mRNA synthesis. The activity of P-TEFb is controlled ma

Externí odkaz: https://doaj.org/article/31b787d1b0f747b2bc7cd4cc019376e2

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Akademický článek

Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.

Autor: Lisa Muniz, Sylvain Egloff, Bettina Ughy, Beáta E Jády, Tamás Kiss

Publikováno v: PLoS Pathogens, Vol 6, Iss 10, p e1001152 (2010)

The human immunodeficiency virus 1 (HIV-1) transcriptional transactivator (Tat) is essential for synthesis of full-length transcripts from the integrated viral genome by RNA polymerase II (Pol II). Tat recruits the host positive transcription elongat

Externí odkaz: https://doaj.org/article/1f0681d1d439433c98b05502496a313e

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Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP

Autor: Yuan Yang, Shiheng Liu, Sylvain Egloff, Catherine D. Eichhorn, Tanya Hadjian, James Zhen, Tamás Kiss, Z. Hong Zhou, Juli Feigon

Publikováno v: Mol Cell
Molecular cell, vol 82, iss 9

7SK non-coding RNA (7SK) negatively regulates RNA polymerase II (RNA Pol II) elongation by inhibiting positive transcription elongation factor b (P-TEFb), and its ribonucleoprotein complex (RNP) is hijacked by HIV-1 for viral transcription and replic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20498d4b7f0714d9fd350d23a9a82327
https://pubmed.ncbi.nlm.nih.gov/35320752

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CDK9 keeps RNA polymerase II on track

Autor: Sylvain Egloff

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (14), pp.5543-5567. ⟨10.1007/s00018-021-03878-8⟩

Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by RNA polymerase II (RNAPII). By releasing promoter-proximally paused RNAPII i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b09adae17ceffb97b2b5c25c0b23657
https://hal.archives-ouvertes.fr/hal-03441042/file/18_2021_Article_3878.pdf

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The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

Autor: Shona Murphy, Cécilia Studniarek, Sylvain Egloff, Pascal G.P. Martin, Michael Tellier, Tamás Kiss

Publikováno v: Cell Reports, Vol 35, Iss 2, Pp 108965-(2021)
Cell Reports
Cell Reports, Elsevier Inc, 2021, 35 (2), pp.108965. ⟨10.1016/j.celrep.2021.108965⟩

International audience; Highlights d The 7SK snRNA is dispensable for cell proliferation under standard growth conditions d After UV exposure, 7SK/P-TEFb is needed for proper stress response and cell survival d P-TEFb extracted from 7SK/P-TEFb trigge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780979e9b1c78a2847a359c79dff87a1
http://www.sciencedirect.com/science/article/pii/S2211124721002795

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Noncoding RNAs Set the Stage for RNA Polymerase II Transcription

Autor: Shona Murphy, Cécilia Studniarek, Sylvain Egloff

Publikováno v: Trends in Genetics
Trends in Genetics, Elsevier, 2020, ⟨10.1016/j.tig.2020.09.013⟩
Trends in Genetics, Elsevier, 2021, 37 (3), pp.279-291. ⟨10.1016/j.tig.2020.09.013⟩

International audience; Effective synthesis of mammalian messenger (m)RNAs depends on many factors that together direct RNA polymerase II (pol II) through the different stages of the transcription cycle and ensure efficient cotranscriptional processi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adb9e5da8d8b87d3c2ce3e2d296161f
https://hal.archives-ouvertes.fr/hal-03002506

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The pol II CTD: new twists in the tail

Autor: Shona Murphy, Sylvain Egloff, Justyna Zaborowska

Publikováno v: Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2016, 23 (9), pp.771-777. ⟨10.1038/nsmb.3285⟩

The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates transcription and cotranscriptional RNA processing. Recently, the spatial pattern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3b16ffcb496437765440de6c8c06ae
https://doi.org/10.1038/nsmb.3285

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Light-responsive pyrazine-based systems: probing aromatic diarylethene photocyclization

Autor: Jovana V. Milić, Renana Gershoni-Poranne, Cédric Schaack, Nora Hellou, Jeanne Crassous, Corinne Boudon, Nils Trapp, Florin Isenrich, Georg Gescheidt, Dmytro Neshchadin, Laurent Ruhlmann, François Diederich, Sylvain Egloff

Publikováno v: The Journal of Physical Chemistry C, 122 (33)
Journal of Physical Chemistry C
Journal of Physical Chemistry C, American Chemical Society, 2018, 122 (33), pp.19100-19109. ⟨10.1021/acs.jpcc.8b05019⟩
Journal of Physical Chemistry C, 2018, 122 (33), pp.19100-19109. ⟨10.1021/acs.jpcc.8b05019⟩

International audience; Here, we present an investigation of the photocyclization of novel aromatic diarylethene (DAE) systems 1-3 based on pyrazine, quinoxaline, and helicene scaffolds. These prospective photoswitches were designed using density fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaea9127ee84547cfaf961fe65131f31
https://hdl.handle.net/20.500.11850/286436

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7SK small nuclear RNA, a multifunctional transcriptional regulatory RNA with gene-specific features

Autor: Sylvain Egloff, Tamás Kiss, Cécilia Studniarek

Publikováno v: Transcription
Transcription, Taylor & Francis, 2018, 9 (2), pp.95-101. ⟨10.1080/21541264.2017.1344346⟩

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-codin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2745a6fb04e84d39b2997d486e8c2b90
https://europepmc.org/articles/PMC5834218/

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The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression

Autor: Patrice Vitali, Tamás Kiss, Michael Tellier, Sylvain Egloff, Raoul Raffel, Shona Murphy

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2017, 36 (7), pp.934-948. ⟨10.15252/embj.201695740⟩

The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, regulates the mRNA elongation capacity of RNA polymerase II (RNAPII) through controlling the nuclear activity of positive transcription elongation fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ad7b3d2d97bdfe1bff3648a1260c42
https://hal.archives-ouvertes.fr/hal-03002510

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