Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sylvain C.P. Eschenlauer"'
Autor:
Gareth D. Westrop, Amy Goundry, Petr Volf, Jeremy C. Mottram, Sylvain C.P. Eschenlauer, Anna Dostalova, Marilia S. Faria, Graham H. Coombs, Lesley S. Morrison, Ana Paula C. A. Lima, Laurence Tetley
Publikováno v:
Cellular Microbiology
Leishmania ISPs are ecotin-like natural peptide inhibitors of trypsin-family serine peptidases, enzymes that are absent from the Leishmania genome. This led to the proposal that ISPs inhibit host serine peptidases and we have recently shown that ISP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2846425ec4ca020acfd7c7b208843229
https://doi.org/10.1111/j.1462-5822.2012.01798.x
https://doi.org/10.1111/j.1462-5822.2012.01798.x
Autor:
Christian Doerig, Clare Fennell, Luc Reininger, Audrey Sicard, Abdirahman I. Abdi, Jean Philippe Semblat, Zoe Holland, Marie-Paule Nivez, Dominique Dorin-Semblat, Jean Halbert, Nicholas D. Bland, Sylvain C.P. Eschenlauer
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:604-612
Malaria still remains one of the deadliest infectious diseases, and has a tremendous morbidity and mortality impact in the developing world. The propensity of the parasites to develop drug resistance, and the relative reluctance of the pharmaceutical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc01f455cc236a40e8184b520055ebc2
https://doi.org/10.1016/j.bbapap.2009.10.009
https://doi.org/10.1016/j.bbapap.2009.10.009
Autor:
Sylvain C.P. Eschenlauer, Marilia S. Faria, Graham H. Coombs, Ana Paula C. A. Lima, Jeremy C. Mottram, Flávia L. Ribeiro-Gomes, George A. DosReis, Lesley S. Morrison, Nicolas Bland
Publikováno v:
Cellular Microbiology
Ecotin is a potent inhibitor of family S1A serine peptidases, enzymes lacking in the protozoan parasite Leishmania major. Nevertheless, L. major has three ecotin-like genes, termed inhibitor of serine peptidase (ISP). ISP1 is expressed in vector-born
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4dd572b8de5bfb93fc617ee2148a83
https://doi.org/10.1111/j.1462-5822.2008.01243.x
https://doi.org/10.1111/j.1462-5822.2008.01243.x
Publikováno v:
Journal of Biological Chemistry. 282:12813-12821
The FK506-binding proteins (FKBs) represent ubiquitous enzymes that catalyze the rate-limiting peptidyl prolyl cis-trans isomerization step in protein folding. The nematode Caenorhabditis elegans has eight FKBs, three of which (FKB-3, -4, and -5) hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134da8b70cefb11daf353112b1330f5f
https://doi.org/10.1074/jbc.m700274200
https://doi.org/10.1074/jbc.m700274200
Publikováno v:
Journal of Biological Chemistry. 278:4227-4237
A novel protein disulfide isomerase gene, pdi-3, was isolated from the nematode Caenorhabditis elegans. This gene encodes an enzyme related to the ERp60 class of thioredoxin proteins and was found to exhibit unusual enzymatic properties. Recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3fbea24b412446ba4f2171acc9a16f
https://doi.org/10.1074/jbc.m210510200
https://doi.org/10.1074/jbc.m210510200
Autor:
Antony P. Page, Malcolm D. Walkinshaw, Paul Taylor, Nichola C. Picken, Sylvain C.P. Eschenlauer
Publikováno v:
Journal of Molecular Biology. 322:15-25
The free-living nematode Caenorhabditis elegans expresses 18 cyclophilin isoforms, eight of which are conserved single domain forms, comprising two closely related secreted or type B forms (CYP-5 and CYP-6). Recombinant CYP-5 has been purified, cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e5f11ca2cb24097f5e03c62aea81cc
https://doi.org/10.1016/s0022-2836(02)00712-x
https://doi.org/10.1016/s0022-2836(02)00712-x
Autor:
Jean-Phillipe Semblat, Mahmood M. Alam, Sharad Mistry, Jean Halbert, Marie-Paule Nivez, Andrew R. Bottrill, Abdirhaman Abdi, Gabriele Pradel, Tenzing Lama, Michele Graciotti, Selina Kern, Andrew B. Tobin, Dominique Dorin-Semblat, Divya Catherine Thomas, Lev Solyakov, Luc Reininger, Zoe Holland, Clare Fennell, Claudia Demarta, Christian Doerig, Yvan Bouza, Pushkar Sharma, Audrey Sicard, Sylvain C.P. Eschenlauer, Shruti Agarwal
Publikováno v:
Nature communications. 2
The role of protein phosphorylation in the life cycle of malaria parasites is slowly emerging. Here we combine global phospho-proteomic analysis with kinome-wide reverse genetics to assess the importance of protein phosphorylation in Plasmodium falci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad832ab6c88cce71cac26bbd62f8446
https://pubmed.ncbi.nlm.nih.gov/22127061
https://pubmed.ncbi.nlm.nih.gov/22127061
Publikováno v:
FEMS microbiology letters. 260(1)
Pyrococcus furiosus protease I (PFPI) is a multimeric cysteine peptidase from P. furiosus. Genome analyses indicate that orthologues are present in rather few other organisms, including Dictyostelium discoideum and several bacteria, Archaea and plant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f2f83a21b8bd9522f6e56658d902a2
https://pubmed.ncbi.nlm.nih.gov/16790017
https://pubmed.ncbi.nlm.nih.gov/16790017
Publikováno v:
Cellular and Molecular Life Sciences
Over the last decade, several protein kinases inhibitors have reached the market for cancer chemotherapy. The kinomes of pathogens represent potentially attractive targets in infectious diseases. The functions of the majority of protein kinases of Pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2430be73822dbf37bc4e86b079b7baff
https://infoscience.epfl.ch/record/149929
https://infoscience.epfl.ch/record/149929
Publikováno v:
FEMS Microbiology Letters; Jul2006, Vol. 260 Issue 1, p47-54, 8p, 4 Diagrams