Large-scale manufacture and characterization of a lentiviral vector produced for clinical ex vivo gene therapy application

Autor: Anne Galy, Maria Antonietta Zanta-Boussif, Muriel Audit, Otto Wilhelm Merten, Marina Radrizzani, Christine Jenny, Sylvain Fauchille, Patricia Noguiez-Hellin, Céline Dugué, Luigi Naldini, Nicolas Laroudie, Hélène Chautard, Giuliana Vallanti, Sabine Charrier

Publikováno v: Human Gene Therapy
Human Gene Therapy, Mary Ann Liebert, 2011, 22 (3), pp.343-56. ⟨10.1089/hum.2010.060⟩
Human Gene Therapy, 2011, 22 (3), pp.343-56. ⟨10.1089/hum.2010.060⟩

International audience; From the perspective of a pilot clinical gene therapy trial for Wiskott-Aldrich syndrome (WAS), we implemented a process to produce a lentiviral vector under good manufacturing practices (GMP). The process is based on the tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5911a7bcc29c71b2b126ec8181eb7f
https://pubmed.ncbi.nlm.nih.gov/21043787

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