Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sylvain Celanire"'
Autor:
Joseph P. Walton, Robert D. Frisina, Sylvain Celanire, Guillaume Albert Jacques Duvey, Xiaoxia Zhu, Reza M. Amanipour
Publikováno v:
EMBC
Acoustic trauma can induce temporary or permanent noise-induced hearing loss (NIHL). Noise exposed animal models allow us to study the effects of various noise trauma insults on the cochlea and auditory pathways. Here we studied the short-term and lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2020d225d7578a9345b0f872c1fd11fc
https://pubmed.ncbi.nlm.nih.gov/30440607
https://pubmed.ncbi.nlm.nih.gov/30440607
Autor:
Iyassu K. Sebhat, Sylvain Celanire, Stephan Schann, Silvia Gatti, Stanislas Mayer, Juergen Wichmann
Publikováno v:
Expert Opinion on Therapeutic Patents. 25:69-90
This review focuses on the medicinal chemistry efforts directed toward the identification of competitive and noncompetitive antagonists of glutamate at group II metabotropic glutamate receptors (mGluRII: mGlu2/3 and mGlu2). This class of compounds ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95050884ccfe28dd20f93bf0710c2067
https://doi.org/10.1517/13543776.2014.983899
https://doi.org/10.1517/13543776.2014.983899
Autor:
Jacob Raber, Matthew J. Davis, Isabelle Royer-Urios, Christelle Bolea, Simon T. Bate, Susan E. Browne, Brice Campo, Francoise Girard, Massimiliano Fonsi, Sylvain Celanire, Jason M. Uslaner, Robert M. Duvoisin, Mikhail Kalinichev, Ian J. Reynolds, Sonia Poli, Emmanuel Le Poul
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:495-505
There is growing evidence that activation of metabotropic glutamate receptor 4 (mGlu4) leads to anxiolytic- and antipsychotic-like efficacy in rodent models, yet its relevance to depression-like reactivity remains unclear. Here, we present the pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f714df4a874e499ee5550929871e889
https://doi.org/10.1124/jpet.114.214437
https://doi.org/10.1124/jpet.114.214437
Autor:
Sylvain Celanire, Sonia Poli
The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug desig
Autor:
Mario Calvitti, Claudia Volpi, Sonia-Maria Poli, Madeleine Heroux, Giada Mondanelli, Maria Laura Belladonna, Silvio Bicciato, Francesca Fallarino, Alberta Iacono, Aldo Solari, Isabelle Royer-Urios, Marco Gargaro, Cinzia Antognelli, Carmine Vacca, Céline Mordant, Mathias Cacquevel, Maria Teresa Pallotta, Paolo Puccetti, Sylvain Celanire, Ursula Grohmann, Roberta Bianchi, Ciriana Orabona, Pierre-Alain Vitte, Manfred Schneider, Elisa Albini, Laurent Galibert
Publikováno v:
Neuropharmacology
Metabotropic glutamate receptor 4 (mGluR4) possesses immune modulatory properties in vivo, such that a positive allosteric modulator (PAM) of the receptor confers protection on mice with relapsing-remitting experimental autoimmune encephalomyelitis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e92821c130279fa59a9d3c6295d4ad
http://hdl.handle.net/11391/1361142
http://hdl.handle.net/11391/1361142
Autor:
Sylvain Celanire, Thierry Demaude, Laurent Provins, Yves Lamberty, Marie-Laure Delporte, Nathalie Van houtvin, Geneviève Lorent, Véronique Durieu, Sabine Defays, Frédéric Denonne, Michel Gillard, Bernard Christophe, Anne Valade, Alain Vanbellinghen, Delphine Hubert, Christel Delaunoy
Publikováno v:
ChemMedChem. 7:2087-2092
The simpler, the better: H(3) histamine receptor (H(3)R) are of interest as therapeutic targets in cognitive and somnolence disorders. Here, lead optimization of H(3)R inverse agonists bearing a thiazolo[5,4-c]piperidine group gave rise to a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1c8a01dc9993b1a09cf14ce69fe7dd
https://doi.org/10.1002/cmdc.201200406
https://doi.org/10.1002/cmdc.201200406
Autor:
Laurent Provins, Michel Gillard, Christel Delaunoy, Frédéric Denonne, Sabine Defays, Jean-Marie Nicolas, Geneviève Lorent, Eric Detrait, Véronique Durieu, Bernard Christophe, Yves Lamberty, Alain Vanbellinghen, Nathalie Van houtvin, Sylvain Celanire, Marie-Laure Delporte
Publikováno v:
ChemMedChem. 6:1559-1565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d838126cb62c79dcc6d4c0028d307312
https://doi.org/10.1002/cmdc.201100248
https://doi.org/10.1002/cmdc.201100248
Autor:
Yves Lamberty, Valérie Verbois, Frédérique Delannois, Frédéric Denonne, Benedicte Lallemand, Véronique Durieu, Bernard Christophe, Geneviève Lorent, Nathalie Van houtvin, Sylvain Celanire, Christel Delaunoy, Franck Atienzar, Marie-Laure Delporte, Alain Vanbellinghen, Michel Gillard, Laurent Provins
Publikováno v:
ChemMedChem. 5:206-212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1d4cd7b1156eb977b5217cd535a926
https://doi.org/10.1002/cmdc.200900446
https://doi.org/10.1002/cmdc.200900446
Autor:
Iwan J. P. de Esch, Yves Lamberty, Patrice Talaga, Valérie Verbois, Rob Leurs, Frédéric Denonne, Florence Lebon, Alain Vanbellinghen, Bernard Christophe, Michel Gillard, Christel Delaunoy, Sylvain Celanire, Edith Gelens, Erwin Snip, Henk Timmerman, Donald Dassesse, Nathalie Van houtvin, Laurent Provins, Benedicte Lallemand, Véronique Durieu, Philippe Collart, Jean-Marie Nicolas, Maikel Wijtmans, Luc Quere
Publikováno v:
ChemMedChem, 4(7), 1063-8. John Wiley and Sons Ltd
Celanire, S, Wijtmans, M, Christophe, B, Collart, P, de Esch, I J P, Dassesse, D, Delaunoy, C, Denonne, F, Durieu, V, Gelens, E, Gillard, M, Lallemand, B, Lamberty, Y, Lebon, F, Nicolas, J M, Quere, L, Snip, E, Vanbellinghen, A, Van Houtvin, N, Verbois, V, Timmerman, H, Talaga, P, Leurs, R & Provins, L 2009, ' Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists ', ChemMedChem, vol. 4, no. 7, pp. 1063-8 . https://doi.org/10.1002/cmdc.200900055
Celanire, S, Wijtmans, M, Christophe, B, Collart, P, de Esch, I J P, Dassesse, D, Delaunoy, C, Denonne, F, Durieu, V, Gelens, E, Gillard, M, Lallemand, B, Lamberty, Y, Lebon, F, Nicolas, J M, Quere, L, Snip, E, Vanbellinghen, A, Van Houtvin, N, Verbois, V, Timmerman, H, Talaga, P, Leurs, R & Provins, L 2009, ' Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists ', ChemMedChem, vol. 4, no. 7, pp. 1063-8 . https://doi.org/10.1002/cmdc.200900055
H(3)R inverse agonists based on an aminopropoxy-phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse model of recognition memory.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543d6a72ee98e4081c29c96d0b654379
https://doi.org/10.1002/cmdc.200900055
https://doi.org/10.1002/cmdc.200900055
Autor:
Bernard Christophe, Philippe P. Collart, Bastiaan J. Venhuis, Maikel Wijtmans, Saskia Hulscher, Benedicte Lallemand, Edith Gelens, Patrice Talaga, Iwan J. P. de Esch, Michel Gillard, Erwin Snip, Sylvain Celanire, Henk Timmerman, Rob Leurs, Henk van der Goot, Florence Lebon, Remko A. Bakker
Publikováno v:
Wijtmans, M, Celanire, S, Snip, E, Gillard, M R, Gelens, E, Collart, P P, Venhuis, B J, Christophe, B, Hulscher, ST, van der Goot, H, Lebon, F, Timmerman, H, Bakker, R A, Leurs, R, Lallemand, B I, Talaga, P & de Esch, I J P 2008, ' 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists ', Journal of Medicinal Chemistry, vol. 51, no. 10, pp. 2944-53 . https://doi.org/10.1021/jm7014149
Journal of Medicinal Chemistry, 51(10), 2944-53. American Chemical Society
Journal of Medicinal Chemistry, 51(10), 2944-53. American Chemical Society
Research on the therapeutic applications of the histamine H3 receptor (H3R) has traditionally focused on antagonists/inverse agonists. In contrast, H3R agonists have received less attention despite their potential use in several disease areas. The lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd14a93395558ca6f0ff4ef04ac36c
https://research.vu.nl/en/publications/47ca4fc4-ef36-48d9-b4ba-e809e2b8d47c
https://research.vu.nl/en/publications/47ca4fc4-ef36-48d9-b4ba-e809e2b8d47c