Structural basis for the inhibition of human angiotensin-1 converting enzyme by fosinoprilat

Autor: Gyles E. Cozier, Emma C. Newby, Sylva L. U. Schwager, R. Elwyn Isaac, Edward D. Sturrock, K. Ravi Acharya

Publikováno v: The FEBS journalReferences. 289(21)

Human angiotensin I-converting enzyme (ACE) has two isoforms, somatic ACE (sACE) and testis ACE (tACE). The functions of sACE are widespread, with its involvement in blood pressure regulation most extensively studied. sACE is composed of an N-domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5298e711158677fe3cb44701c28de217
https://pubmed.ncbi.nlm.nih.gov/35653492

Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb)

Autor: Lauren B. Arendse, Lizelle Lubbe, Sylva L. U. Schwager, Afolake T. Arowolo, Emma Ruth Belcher, Gyles E. Cozier, Edward D. Sturrock, K. Ravi Acharya

Publikováno v: The Biochemical journal. 476(10)

Angiotensin-converting enzyme (ACE) is a zinc metalloprotease best known for its role in blood pressure regulation. ACE consists of two homologous catalytic domains, the N- and C-domain, that display distinct but overlapping catalytic functions in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61169c441440cdf42218942b8d90a610
https://pubmed.ncbi.nlm.nih.gov/31072910

Therapeutic drug monitoring of amlodipine and the Z-FHL/HHL ratio: Adherence tools in patients referred for apparent treatment-resistant hypertension

Autor: Sandra Castel, Sylva L. U. Schwager, Erika Jones, Eric H Decloedt, Marc Blockman, Edward D. Sturrock, Maia Lesosky, Lubbe Wiesner, Brian Rayner

Publikováno v: SAMJ: South African Medical Journal, Volume: 107, Issue: 10, Pages: 887-891, Published: OCT 2017
South African Medical Journal; Vol 107, No 10 (2017)
South African Medical Journal, Vol 107, Iss 10, Pp 887-891 (2017)

Background. Non-adherence to antihypertensives is a cause of ‘pseudo-treatment-resistant’ hypertension. Objective. To determine whether monitoring plasma amlodipine concentrations and inhibition of angiotensin-converting enzyme (ACE) can be adjun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0bf468a1af46e9cc545d438b75f7e6
http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742017001000020&lng=en&tlng=en

The N Domain of Human Angiotensin-I-converting Enzyme

Autor: Hazel R. Corradi, Edward D. Sturrock, Colin Anthony, Pierre Redelinghuys, Vincent Dive, Sylva L. U. Schwager, K. Ravi Acharya, Dimitris Georgiadis

Publikováno v: The Journal of Biological Chemistry

Angiotensin-I-converting enzyme (ACE) plays a critical role in the regulation of blood pressure through its central role in the renin-angiotensin and kallikrein-kinin systems. ACE contains two domains, the N and C domains, both of which are heavily g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ebf6a677ba9a2a5b70faa7ff9b0303
http://europepmc.org/articles/PMC2975193

Structure of Testis ACE Glycosylation Mutants and Evidence for Conserved Domain Movement

Autor: Hazel R. Corradi, K. Ravi Acharya, Sylva L. U. Schwager, Ramanathan Natesh, B. Trevor Sewell, Edward D. Sturrock, Jean M. Watermeyer

Publikováno v: Biochemistry. 45:12654-12663

Human angiotensin-converting enzyme is an important drug target for which little structural information has been available until recent years. The slow progress in obtaining a crystal structure was due to the problem of surface glycosylation, a diffi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf167fc4370a65c78c84be891aa4dbc
https://doi.org/10.1021/bi061146z