Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sylva L Schwager"'
Autor:
Lauren B. Arendse, Gyles E. Cozier, Charles J. Eyermann, Gregory S. Basarab, Sylva L. Schwager, Kelly Chibale, K. Ravi Acharya, Edward D. Sturrock
Publikováno v:
Arendse, L B, Cozier, G, Eyermann, C, Basarab, G, Schwager, S L U, Chibale, K, Acharya, R & Sturrock, E D 2022, ' Probing the requirements for dual angiotensin-converting enzyme C-domain selective/neprilysin inhibition ', Journal of Medicinal Chemistry, vol. 65, no. 4, pp. 3371-3387 . https://doi.org/10.1021/acs.jmedchem.1c01924
Selective inhibition of the angiotensin-converting enzyme C-domain (cACE) and neprilysin (NEP), leaving the ACE N-domain (nACE) free to degrade bradykinin and other peptides, has the potential to provide the potent antihypertensive and cardioprotecti
Autor:
Sergei M Danilov, Michael S Wade, Sylva L Schwager, Ross G Douglas, Andrew B Nesterovitch, Isolda A Popova, Kyle D Hogarth, Nakul Bhardwaj, David E Schwartz, Edward D Sturrock, Joe G N Garcia
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88001 (2014)
BACKGROUND: Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of biologically-active peptides including the hemoregulatory tetrapeptide, Ac-SDKP, hydrolysed preferential
Externí odkaz:
https://doaj.org/article/ffe120ace2814c07ab74584edaa8d8c5
Publikováno v:
Journal of medicinal chemistry. 61(22)
Omapatrilat was designed as a vasopeptidase inhibitor with dual activity against the zinc metallopeptidases angiotensin-1 converting enzyme (ACE) and neprilysin (NEP). ACE has two homologous catalytic domains (nACE and cACE), which exhibit different
Autor:
Gyles E, Cozier, Sylva L, Schwager, Rajni K, Sharma, Kelly, Chibale, Edward D, Sturrock, K Ravi, Acharya
Publikováno v:
The Febs Journal
Angiotensin‐1‐converting enzyme (ACE) is a zinc metallopeptidase that consists of two homologous catalytic domains (known as nACE and cACE) with different substrate specificities. Based on kinetic studies it was previously reported that sampatril
Autor:
Kate M, Larmuth, Geoffrey, Masuyer, Ross G, Douglas, Sylva L, Schwager, K Ravi, Acharya, Edward D, Sturrock
Publikováno v:
The Febs Journal
Angiotensin‐1‐converting enzyme (ACE), a zinc metallopeptidase, consists of two homologous catalytic domains (N and C) with different substrate specificities. Here we report kinetic parameters of five different forms of human ACE with various amy
Autor:
Cozier, Gyles E.1, Schwager, Sylva L.2, Sharma, Rajni K.3, Chibale, Kelly3, Sturrock, Edward D.2, Acharya, K. Ravi1 bsskra@bath.ac.uk
Publikováno v:
FEBS Journal. Apr2018, Vol. 285 Issue 8, p1477-1490. 14p.
Autor:
Larmuth, Kate M.1, Masuyer, Geoffrey2, Douglas, Ross G.1, Schwager, Sylva L.1, Acharya, K. Ravi2, Sturrock, Edward D.1
Publikováno v:
FEBS Journal. Mar2016, Vol. 283 Issue 6, p1060-1076. 17p.
Autor:
Danilov, Sergei M.1,2 danilov@uic.edu, Wade, Michael S.1, Schwager, Sylva L.3, Douglas, Ross G.3, Nesterovitch, Andrew B.4, Popova, Isolda A.5, Hogarth, Kyle D.6, Bhardwaj, Nakul6, Schwartz, David E.2, Sturrock, Edward D.3, Garcia, Joe G. N.7
Publikováno v:
PLoS ONE. Feb2014, Vol. 9 Issue 2, p1-12. 12p.
Publikováno v:
Urological Research; Dec2006, Vol. 34 Issue 6, p373-380, 8p, 2 Charts, 3 Graphs