Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sylke Muller"'
Autor:
Weam Siheri, Godwin U. Ebiloma, John O. Igoli, Alexander I. Gray, Marco Biddau, Pilaslak Akrachalanont, Samya Alenezi, Mohammad A. Alwashih, RuAngelie Edrada-Ebel, Sylke Muller, Catherine E. Lawrence, James Fearnley, David G. Watson, Harry P. De Koning
Publikováno v:
Molecules, Vol 24, Iss 6, p 1041 (2019)
Twelve propolis samples from different parts of Libya were investigated for their phytochemical constituents. Ethanol extracts of the samples and some purified compounds were tested against Trypanosoma brucei, Plasmodium falciparum and against two he
Externí odkaz:
https://doaj.org/article/a75a95b7a3984657911d22e2945be40e
Autor:
Weam Siheri, Tong Zhang, Godwin Unekwuojo Ebiloma, Marco Biddau, Nicola Woods, Muattaz Yassein Hussain, Carol J Clements, James Fearnley, RuAngelie Edrada Ebel, Timothy Paget, Sylke Muller, Katharine C Carter, Valerie A Ferro, Harry P De Koning, David G Watson
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155355 (2016)
Extracts from twelve samples of propolis collected from different regions of Libya were tested for their activity against Trypanosoma brucei, Leishmania donovani, Plasmodium falciparum, Crithidia fasciculata and Mycobacterium marinum and the cytotoxi
Externí odkaz:
https://doaj.org/article/080c68b35d654766bdc136455b64ef0d
Publikováno v:
Tropical Medicine and International Health. 2:472-481
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b78ab3e2e933c1eb393730b81619c979
https://doi.org/10.1046/j.1365-3156.1997.d01-294.x
https://doi.org/10.1046/j.1365-3156.1997.d01-294.x
Autor:
Guiomar Pérez-Moreno, Paula Sánchez-Carrasco, Luis Miguel Ruiz-Pérez, Nils Gunnar Johansson, Sylke Müller, Beatriz Baragaña, Shahienaz Emma Hampton, Ian Hugh Gilbert, Marcel Kaiser, Sandipan Sarkar, Thiyagamurthy Pandurangan, Vijeesh Kumar, Dolores González-Pacanowska
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective vaccine, the search of novel anti-m
Externí odkaz:
https://doaj.org/article/a40f1ef15b204c75a6f032176c445e23
Autor:
Sylke Müller
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10511-10534 (2015)
Malaria in humans is caused by one of five species of obligate intracellular protozoan parasites of the genus Plasmodium. P. falciparum causes the most severe disease and is responsible for 600,000 deaths annually, primarily in Sub-Saharan Africa. It
Externí odkaz:
https://doaj.org/article/32956d51e3524243b09a21b6243f8c8f
Autor:
Anubhav Srivastava, Darren J Creek, Krystal J Evans, David De Souza, Louis Schofield, Sylke Müller, Michael P Barrett, Malcolm J McConville, Andrew P Waters
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004882 (2015)
Human malaria parasites proliferate in different erythroid cell types during infection. Whilst Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more pathogenic P. falciparum primarily infects mature erythrocytes. In order
Externí odkaz:
https://doaj.org/article/9bc6ca8c070c4ffc8568e3088a312a18
Autor:
Manuela S Pieperhoff, Gurman S Pall, Elena Jiménez-Ruiz, Sujaan Das, Carmen Melatti, Matthew Gow, Eleanor H Wong, Joanne Heng, Sylke Müller, Michael J Blackman, Markus Meissner
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130356 (2015)
The functional characterisation of essential genes in apicomplexan parasites, such as Toxoplasma gondii or Plasmodium falciparum, relies on conditional mutagenesis systems. Here we present a novel strategy based on U1 snRNP-mediated gene silencing. U
Externí odkaz:
https://doaj.org/article/acaad93cffd543fbb349e6c90b019fb4
Autor:
Janet Storm, Sonal Sethia, Gavin J Blackburn, Achuthanunni Chokkathukalam, David G Watson, Rainer Breitling, Graham H Coombs, Sylke Müller
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003876 (2014)
Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(
Externí odkaz:
https://doaj.org/article/d2a64c2bb86a48999a10a5353d42d4ef
Autor:
Saskia Decuypere, Manu Vanaerschot, Kirstyn Brunker, Hideo Imamura, Sylke Müller, Basudha Khanal, Suman Rijal, Jean-Claude Dujardin, Graham H Coombs
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1514 (2012)
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is uni
Externí odkaz:
https://doaj.org/article/3cc11c779a5c45b59e37c9791843ce84
Autor:
Mads Gabrielsen, Katherine S H Beckham, Victoria A Feher, Caroline E Zetterström, Dai Wang, Sylke Müller, Mikael Elofsson, Rommie E Amaro, Olwyn Byron, Andrew J Roe
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32217 (2012)
Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced sta
Externí odkaz:
https://doaj.org/article/f1d1bcf768034b47ad2805c83446d23a