Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Sylke MüLLER"'
Autor:
Guiomar Pérez-Moreno, Paula Sánchez-Carrasco, Luis Miguel Ruiz-Pérez, Nils Gunnar Johansson, Sylke Müller, Beatriz Baragaña, Shahienaz Emma Hampton, Ian Hugh Gilbert, Marcel Kaiser, Sandipan Sarkar, Thiyagamurthy Pandurangan, Vijeesh Kumar, Dolores González-Pacanowska
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective vaccine, the search of novel anti-m
Externí odkaz:
https://doaj.org/article/a40f1ef15b204c75a6f032176c445e23
Autor:
Sylke Müller
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10511-10534 (2015)
Malaria in humans is caused by one of five species of obligate intracellular protozoan parasites of the genus Plasmodium. P. falciparum causes the most severe disease and is responsible for 600,000 deaths annually, primarily in Sub-Saharan Africa. It
Externí odkaz:
https://doaj.org/article/32956d51e3524243b09a21b6243f8c8f
Autor:
Anubhav Srivastava, Darren J Creek, Krystal J Evans, David De Souza, Louis Schofield, Sylke Müller, Michael P Barrett, Malcolm J McConville, Andrew P Waters
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004882 (2015)
Human malaria parasites proliferate in different erythroid cell types during infection. Whilst Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more pathogenic P. falciparum primarily infects mature erythrocytes. In order
Externí odkaz:
https://doaj.org/article/9bc6ca8c070c4ffc8568e3088a312a18
Autor:
Manuela S Pieperhoff, Gurman S Pall, Elena Jiménez-Ruiz, Sujaan Das, Carmen Melatti, Matthew Gow, Eleanor H Wong, Joanne Heng, Sylke Müller, Michael J Blackman, Markus Meissner
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130356 (2015)
The functional characterisation of essential genes in apicomplexan parasites, such as Toxoplasma gondii or Plasmodium falciparum, relies on conditional mutagenesis systems. Here we present a novel strategy based on U1 snRNP-mediated gene silencing. U
Externí odkaz:
https://doaj.org/article/acaad93cffd543fbb349e6c90b019fb4
Autor:
Janet Storm, Sonal Sethia, Gavin J Blackburn, Achuthanunni Chokkathukalam, David G Watson, Rainer Breitling, Graham H Coombs, Sylke Müller
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003876 (2014)
Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(
Externí odkaz:
https://doaj.org/article/d2a64c2bb86a48999a10a5353d42d4ef
Autor:
Saskia Decuypere, Manu Vanaerschot, Kirstyn Brunker, Hideo Imamura, Sylke Müller, Basudha Khanal, Suman Rijal, Jean-Claude Dujardin, Graham H Coombs
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1514 (2012)
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is uni
Externí odkaz:
https://doaj.org/article/3cc11c779a5c45b59e37c9791843ce84
Autor:
Mads Gabrielsen, Katherine S H Beckham, Victoria A Feher, Caroline E Zetterström, Dai Wang, Sylke Müller, Mikael Elofsson, Rommie E Amaro, Olwyn Byron, Andrew J Roe
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32217 (2012)
Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced sta
Externí odkaz:
https://doaj.org/article/f1d1bcf768034b47ad2805c83446d23a
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5510 (2009)
Lipoic acid (LA) is a dithiol-containing cofactor that is essential for the function of alpha-keto acid dehydrogenase complexes. LA acts as a reversible acyl group acceptor and 'swinging arm' during acyl-coenzyme A formation. The cofactor is post-tra
Externí odkaz:
https://doaj.org/article/6b87186778214a51b9b51843e1acbe14
Autor:
Svenja Günther, Lynsey Wallace, Eva-Maria Patzewitz, Paul J McMillan, Janet Storm, Carsten Wrenger, Ryan Bissett, Terry K Smith, Sylke Müller
Publikováno v:
PLoS Pathogens, Vol 3, Iss 12, p e189 (2007)
Lipoic acid (LA) is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways. Biosynthesis of LA exclusively occurs
Externí odkaz:
https://doaj.org/article/252a1ea7e85545459b36b533bd9436f1
Autor:
Achuthanunni Chokkathukalam, David A. Fidock, Marco Biddau, T. R. Santha Kumar, Stephen L. Hoffman, Lewis J King, Larissa M. Laine, Graham H. Coombs, Geoffrey I. McFadden, Philipp P. Henrich, Michael P. Barrett, Kim Lee Sim, Gavin Blackburn, Tao Li, Lilach Sheiner, Sylke Müller
Publikováno v:
International Journal for Parasitology
Graphical abstract
Highlights • Apicoplast LipB deletion leads to changed antioxidant expression that precedes and coincides with accelerated differentiation. • 3D7 Plasmodium exhibits changes in glycolysis and tricarboxylic acid cycle activ
Highlights • Apicoplast LipB deletion leads to changed antioxidant expression that precedes and coincides with accelerated differentiation. • 3D7 Plasmodium exhibits changes in glycolysis and tricarboxylic acid cycle activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1af396c0cc1a2654b6cf40fde8641b1
https://doi.org/10.1016/j.ijpara.2020.10.011
https://doi.org/10.1016/j.ijpara.2020.10.011