Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Syevda G, Sirenko"'
Autor:
Syevda G Sirenko, Dongmei Yang, Larissa A Maltseva, Mary S Kim, Edward G Lakatta, Victor A Maltsev
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185222 (2017)
Uptake and release calcium from the sarcoplasmic reticulum (SR) (dubbed "calcium clock"), in the form of spontaneous, rhythmic, local diastolic calcium releases (LCRs), together with voltage-sensitive ion channels (membrane clock) form a coupled syst
Externí odkaz:
https://doaj.org/article/8d885deea16742c3adf90690afcf3da6
Autor:
Bruce D. Ziman, Kirill V. Tarasov, Yelena S. Tarasova, Michael D. Stern, Jing Zhang, Jaclyn A. Brennan, Igor R. Efimov, Rostislav Bychkov, Alexander V. Maltsev, Syevda G. Sirenko-Tagirova, Mary S. Kim, Kenta Tsutsui, Victor A. Maltsev, Larissa A. Maltseva, Oliver Monfredi, Mingyi Wang, Edward G. Lakatta
Publikováno v:
Science signaling. 11(534)
The spontaneous rhythmic action potentials generated by the sinoatrial node (SAN), the primary pacemaker in the heart, dictate the regular and optimal cardiac contractions that pump blood around the body. Although the heart rate of humans is substant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302cc69cdbd02d567bd16d90e6c9a9d8
https://pubmed.ncbi.nlm.nih.gov/29895616
https://pubmed.ncbi.nlm.nih.gov/29895616
Publikováno v:
The Journal of Physiology. 575:201-213
Troponin T (TnT) mutations that cause familial hypertrophic cardiomyopathy (FHC) and sudden cardiac death frequently increase myofilament Ca2+ sensitivity, suggesting that their Ca2+-sensitizing effect contributes importantly to the FHC pathogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d6111b83198c0c7d50efe9c1bbd231b
https://doi.org/10.1113/jphysiol.2006.107557
https://doi.org/10.1113/jphysiol.2006.107557
Autor:
Jiaju Zhao, Todd Miller, Yuanyuan Xu, W. Glenn L. Kerrick, Bjorn C. Knollmann, Danuta Szczesna-Cordary, Ying Wang, Zoraida Diaz, James D. Potter, Olga M. Hernandez, Syevda G. Sirenko, Georgianna Guzman, Michael D. Bell
Publikováno v:
Journal of Biological Chemistry. 280:37183-37194
We have studied the physiological effects of the troponin T (TnT) F110I and R278C mutations associated with familial hypertrophic cardiomyopathy (FHC) in humans. Three to four-month-old transgenic (Tg) mice expressing F110I-TnT and R278C-TnT did not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0965605a275e48f0499c3673570bc932
https://doi.org/10.1074/jbc.m508114200
https://doi.org/10.1074/jbc.m508114200
Autor:
Anna V, Maltsev, Victor A, Maltsev, Maxim, Mikheev, Larissa A, Maltseva, Syevda G, Sirenko, Edward G, Lakatta, Michael D, Stern
Publikováno v:
Biophysical journal. 100(2)
In sinoatrial node cells of the heart, beating rate is controlled, in part, by local Ca²(+) releases (LCRs) from the sarcoplasmic reticulum, which couple to the action potential via electrogenic Na(+)/Ca²(+) exchange. We observed persisting, roughl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b41ce0b5c54fb11adc145421fe809527
https://pubmed.ncbi.nlm.nih.gov/21244823
https://pubmed.ncbi.nlm.nih.gov/21244823
Autor:
Syevda G. Sirenko, Alexey E. Lyashkov, Dongmei Yang, Edward G. Lakatta, Tatiana M. Vinogradova
Publikováno v:
Circulation. 116
To maintain their normal automaticity, sinoatrial nodal cells (SANC) have a unique property to generate spontaneous, local Ca 2+ release (LCR) from sarcoplasmic reticulum (SR) under physiological conditions. To further characterize the mechanisms tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c713b06e96ccfce4eecd6c549db026bb
https://doi.org/10.1161/circ.116.suppl_16.ii_85-a
https://doi.org/10.1161/circ.116.suppl_16.ii_85-a
Autor:
Yue Li, Syevda G. Sirenko, Tatiana M. Vinogradova, Alexey E. Lyashkov, Weizhong Zhu, Magdalena Juhaszova, Bruce Ziman, Su Wang, Edward G. Lakatta
Publikováno v:
Circulation. 116
The crucial dependence of normal automaticity of sinoatrial nodal cells (SANC) on CaMKII signaling has previously been linked to an effect to facilitate recovery from inactivation of L-type Ca 2+ channels. More recently, however, it has been discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd08a9d95bb52e16dc0babe84684012
https://doi.org/10.1161/circ.116.suppl_16.ii_86-c
https://doi.org/10.1161/circ.116.suppl_16.ii_86-c
Autor:
Alexander N. Katchman, Mathew C. Casimiro, Syevda G. Sirenko, Bjorn C. Knollmann, Karl Pfeifer, Steven N. Ebert, Qi Rong
Publikováno v:
Biochemical and biophysical research communications. 360(1)
It has been suggested that Kcne1 subunits are required for adrenergic regulation of Kcnq1 potassium channels. However, in adult mouse hearts, which do not express Kcne1, loss of Kcnq1 causes a Long QT phenotype during adrenergic challenge, raising th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84bf041e6fbb9c8883eb0e484ccd705
https://pubmed.ncbi.nlm.nih.gov/17597584
https://pubmed.ncbi.nlm.nih.gov/17597584
Autor:
Bjorn C. Knollmann, Tilmann Schober, Andreas O. Petersen, Syevda G. Sirenko, Michael R. Franz
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 292(1)
Transgenic mice have been increasingly utilized to investigate the molecular mechanisms of cardiac arrhythmias, yet the rate dependence of the murine action potential duration and the electrical restitution curve (ERC) remain undefined. In the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca030d4960ffee41a149b306c925d08
https://pubmed.ncbi.nlm.nih.gov/16963611
https://pubmed.ncbi.nlm.nih.gov/16963611
Autor:
Karl Pfeifer, Mathew C. Casimiro, Jay C. Vary, Liping Nie, Alexander Grinberg, Bjoern C. Knollmann, Steven N. Ebert, Anne E. Greene, Sing Ping Huang, Syevda G. Sirenko, Ebenezer N. Yamoah
Publikováno v:
Genomics. 84(3)
Inherited long QT syndrome is most frequently associated with mutations in KCNQ1, which encodes the primary subunit of a potassium channel. Patients with mutations in KCNQ1 may show only the cardiac defect (Romano-Ward syndrome or RWS) or may also ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0dd5c87ea1faf19864621da6105c8a
https://pubmed.ncbi.nlm.nih.gov/15498462
https://pubmed.ncbi.nlm.nih.gov/15498462