Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Syeed Hussain"'
Autor:
Craig S. Donald, Galith Karoutchi, Syeed Hussain, Peter Ballard, Gordon S. Currie, Barry R. Hayter, Hazel M. Weir, H. Gingell, Richard A. Norman, Steven C. Glossop, David Buttar, Lyman Feron, Zena Wilson, Stuart E. Pearson, Camila de Almeida, Christopher D. Davies, Rowena Callis, Philip A. MacFaul, Thomas A. Moss, Chris De Savi, Alfred A. Rabow, David M. Andrews, Graeme Walker, Michael Tonge, Scott G. Lamont, Jon Curwen, Robert Hugh Bradbury
Publikováno v:
Journal of Medicinal Chemistry. 58:8128-8140
The discovery of an orally bioavailable selective estrogen receptor downregulator (SERD) with equivalent potency and preclinical pharmacology to the intramuscular SERD fulvestrant is described. A directed screen identified the 1-aryl-2,3,4,9-tetrahyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9d21c50ca9de0e32e23964631039a67
https://doi.org/10.1021/acs.jmedchem.5b00984
https://doi.org/10.1021/acs.jmedchem.5b00984
Autor:
Jiaquan Wu, Jon Read, Shan Huang, Geraldine Bebernitz, Michael Zinda, Syeed Hussain, Marat Alimzhanov, Kirsten Bell, Nancy DeGrace, Michelle Lamb, Guan Huiping, Caroline Rivard, Stephanos Ioannidis, Minwei Ye, Bo Peng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3105-3110
The discovery of the activating mutation V617F in the JH2 domain of Jak2 and the modulation of oncogenic Stat3 by Jak2 inhibitors have spurred a great interest in the inhibition of the Jak2/Stat pathway in oncology. In this Letter, we communicate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6a2791a8a3f7af3ef48c74521912bf
https://doi.org/10.1016/j.bmcl.2013.02.111
https://doi.org/10.1016/j.bmcl.2013.02.111
Autor:
Emrys W. Thomas, Syeed Hussain, Chandra S. Verma, Akavish Khan, Marina Resmini, Keith Brocklehurst, Sheraz Gul
Publikováno v:
Biochemistry. 50:10732-10742
Understanding the roles of noncovalent interactions within the enzyme molecule and between enzyme and substrate or inhibitor is an essential goal of the investigation of active center chemistry and catalytic mechanism. Studies on members of the papai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c72e8eda1055e5a172b3da4324fad04
https://doi.org/10.1021/bi201207z
https://doi.org/10.1021/bi201207z
Structural Insights into Substrate Specificity and the anti β-Elimination Mechanism of Pectate Lyase
Autor:
Mads Hartvig Clausen, Robert Madsen, Richard W. Pickersgill, Teng Teng To, Susana Teixteira, Salyha Ali, Keith Brocklehurst, Markus Fries, Arefeh Seyedarabi, Syeed Hussain
Publikováno v:
Biochemistry. 49:539-546
Pectate lyases harness anti beta-elimination chemistry to cleave the alpha-1,4 linkage in the homogalacturonan region of plant cell wall pectin. We have studied the binding of five pectic oligosaccharides to Bacillus subtilis pectate lyase in crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6120eee6321020bea6115f4e776ee46
https://doi.org/10.1021/bi901503g
https://doi.org/10.1021/bi901503g
Autor:
Chris, De Savi, Robert H, Bradbury, Alfred A, Rabow, Richard A, Norman, Camila, de Almeida, David M, Andrews, Peter, Ballard, David, Buttar, Rowena J, Callis, Gordon S, Currie, Jon O, Curwen, Chris D, Davies, Craig S, Donald, Lyman J L, Feron, Helen, Gingell, Steven C, Glossop, Barry R, Hayter, Syeed, Hussain, Galith, Karoutchi, Scott G, Lamont, Philip, MacFaul, Thomas A, Moss, Stuart E, Pearson, Michael, Tonge, Graeme E, Walker, Hazel M, Weir, Zena, Wilson
Publikováno v:
Journal of medicinal chemistry. 58(20)
The discovery of an orally bioavailable selective estrogen receptor downregulator (SERD) with equivalent potency and preclinical pharmacology to the intramuscular SERD fulvestrant is described. A directed screen identified the 1-aryl-2,3,4,9-tetrahyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bf02eb9c226ce899348ab9e43e0a9dd
https://pubmed.ncbi.nlm.nih.gov/26407012
https://pubmed.ncbi.nlm.nih.gov/26407012
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 62:1287-1293
The crystal structure of internalin C (InlC) from Listeria monocytogenes has been determined at 2.0 A resolution. Several observations implicate InlC in infection: inlC has the same transcriptional activator as other virulence genes, it is only prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fd6ac62ed3469957445060afad00ac
https://doi.org/10.1107/s0907444906026746
https://doi.org/10.1107/s0907444906026746
Autor:
James D. REID, Syeed HUSSAIN, Suneal K. SREEDHARAN, Tamara S. F. BAILEY, Surapong PINITGLANG, Emrys W. THOMAS, Chandra S. VERMA, Keith BROCKLEHURST
Publikováno v:
Biochemical Journal. 357:343-352
The possibility of a slow post-acylation conformational change during catalysis by cysteine proteinases was investigated by using a new chromogenic substrate, N-acetyl-Phe-Gly methyl thionoester, four natural variants (papain, caricain, actinidin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d07452fb9f71af1bc8528b6956ceed
https://doi.org/10.1042/bj3570343
https://doi.org/10.1042/bj3570343
Autor:
John M. Kelly, Richard Harris, Sunita Sardiwal, Shane R. Wilkinson, Shreenal Patel, Snezana Djordjevic, Paul C. Driscoll, Syeed Hussain
Publikováno v:
The Biochemical journal. 425(3)
Current drug therapies against Trypanosoma cruzi, the causative agent of Chagas disease, have limited effectiveness and are highly toxic. T. cruzi-specific metabolic pathways that utilize trypanothione for the reduction of peroxides are being explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018ecbd25505c9c9101bfe27541b359c
https://pubmed.ncbi.nlm.nih.gov/19886864
https://pubmed.ncbi.nlm.nih.gov/19886864
Autor:
Chandra S. Verma, Sheraz Gul, Mark P. Thomas, Syeed Hussain, Emrys W. Thomas, Keith Brocklehurst, Marina Resmini
Publikováno v:
Biochemistry. 47(7)
Studies on papain (EC 3.4.22.2), the most thoroughly investigated member of the cysteine proteinase superfamily, have contributed substantially to our understanding of the roles of noncovalent interactions in enzyme active center chemistry. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d153aa7883ccd4675c062f56457008
https://pubmed.ncbi.nlm.nih.gov/18225918
https://pubmed.ncbi.nlm.nih.gov/18225918
Autor:
Sanjiv Sonkaria, Syeed Hussain, Gerard Gallacher, Sheraz Gul, Elizabeth L. Ostler, Marina Resmini, Guillaume Boucher, Emrys W. Thomas, José Florez-Alvarez, Bilal Said, Keith Brocklehurst
Publikováno v:
The Biochemical journal. 381(Pt 1)
The substrate selectivities of an anti-phosphonate and an anti-phosphate kinetically homogeneous polyclonal catalytic antibody preparation and two hydrolytic enzymes were compared by using hapten-analogous and truncated carbonate and ester substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6eedac1f3607760ce9ee704c6eccb9
https://pubmed.ncbi.nlm.nih.gov/15053743
https://pubmed.ncbi.nlm.nih.gov/15053743