Výsledky vyhledávání - "Syed Umbreen"

Akademický článek

Mini-XT, a miniaturized tagmentation-based protocol for efficient sequencing of SARS-CoV-2

Autor: Marc Fuchs, Clara Radulescu, Miao Tang, Arun Mahesh, Deborah Lavin, Syed Umbreen, James McKenna, Mark Smyth, Eilís McColgan, Zoltan Molnar, Chris Baxter, Timofey Skvortsov, Aditi Singh, Fiona Rogan, Julia Miskelly, Stephen Bridgett, Derek Fairley, David A. Simpson

Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-11 (2022)

Abstract Background The COVID-19 pandemic has highlighted the importance of whole genome sequencing (WGS) of SARS-CoV-2 to inform public health policy. By enabling definition of lineages it facilitates tracking of the global spread of the virus. The

Externí odkaz: https://doaj.org/article/d0a26f61b2eb437880f7f489c8826b77

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Figure S1-S2 from COMMD3:BMI1 Fusion and COMMD3 Protein Regulate C-MYC Transcription: Novel Therapeutic Target for Metastatic Prostate Cancer

Autor: Mohammad Saleem, Badrinath R. Konety, Eva Corey, Colm Morrissey, Paari Murugan, Firdous H. Beigh, Raihana Maqbool, Marina G. Ferrari, Arsheed A. Ganaie, Adrian P. Mansini, Anmbreen Jamroze, Mudassir Meraj Banday, Syed Umbreen

Supplementary Data showing (i) expression of COMMD3 in PDX models and (ii) association of MYC to COMMD3 in prostate cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b8280bae0526c5a0e3ca73d5aa7376
https://doi.org/10.1158/1535-7163.22510041

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Data from BMI1 Drives Metastasis of Prostate Cancer in Caucasian and African-American Men and Is A Potential Therapeutic Target: Hypothesis Tested in Race-specific Models

Autor: Mohammad Saleem, Luke H. Hoeppner, Badrinath R. Konety, Yibin Deng, Shahriar Koochekpour, Colm Morrissey, Paari Murugan, Tabish Hussain, Hifzur R. Siddique, Aijaz S. Parray, Syed Umbreen, Raihana Maqbool, Marina G. Ferrari, Matteo Astone, Firdous H. Beigh, Arsheed A. Ganaie

Purpose:Metastasis is the major cause of mortality in prostate cancer patients. Factors such as genetic makeup and race play critical role in the outcome of therapies. This study was conducted to investigate the relevance of BMI1 in metastatic prosta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c698935c754116ab92b77313e6709fb9
https://doi.org/10.1158/1078-0432.c.6527055.v1

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figure S2 from BMI1 Drives Metastasis of Prostate Cancer in Caucasian and African-American Men and Is A Potential Therapeutic Target: Hypothesis Tested in Race-specific Models

Supplementary Figure 2. Inhibition of colony formation by BMI1 inhibitor and Docetaxel combination in African American and Caucasian CaP models on Colony-formation assay as described in material and methods.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30a006644acd083d8f05952b0771257
https://doi.org/10.1158/1078-0432.22468788

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Supplemental legend from BMI1 Drives Metastasis of Prostate Cancer in Caucasian and African-American Men and Is A Potential Therapeutic Target: Hypothesis Tested in Race-specific Models

Supplemental legend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5452d09d134842995be1682aaec1326
https://doi.org/10.1158/1078-0432.22468794.v1

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Table S1 from BMI1 Drives Metastasis of Prostate Cancer in Caucasian and African-American Men and Is A Potential Therapeutic Target: Hypothesis Tested in Race-specific Models

Supplementary Table 1. Sequence of primers used for ChIP analysis of PTEN, INK4A/p16 and GAPDH promoters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2860bbb29e651f61cca8218c9b909234
https://doi.org/10.1158/1078-0432.22468791

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COMMD3:BMI1 Fusion and COMMD3 Protein Regulate C-MYC Transcription: Novel Therapeutic Target for Metastatic Prostate Cancer

Autor: Arsheed A. Ganaie, Mohammad Saleem, Badrinath R. Konety, Paari Murugan, Syed Umbreen, Adrian P. Mansini, Anmbreen Jamroze, Marina G. Ferrari, Raihana Maqbool, Colm Morrissey, Mudassir M. Banday, Firdous H. Beigh, Eva Corey

Publikováno v: Molecular Cancer Therapeutics. 18:2111-2123

Gene rearrangement is reported to be associated to the aggressive phenotype and poor prognosis in prostate cancer. We identified a gene fusion between a transcription repressor (BMI1) and transcriptional factor (COMMD3) in human prostate cancer. We s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b589f0008588a0fb0cc4e008ed43bfc
https://doi.org/10.1158/1535-7163.mct-19-0150

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BMI1 drives metastasis of prostate cancer in Caucasian and African-American men and is a potential therapeutic target: hypothesis tested in race-specific models

Autor: Aijaz Parray, Matteo Astone, Arsheed A. Ganaie, Syed Umbreen, Mohammad Saleem, Tabish Hussain, Badrinath R. Konety, Marina G. Ferrari, Shahriar Koochekpour, Colm Morrissey, Paari Murugan, Hifzur R. Siddique, Luke H. Hoeppner, Yibin Deng, Raihana Maqbool, Firdous H. Beigh

Purpose: Metastasis is the major cause of mortality in prostate cancer patients. Factors such as genetic makeup and race play critical role in the outcome of therapies. This study was conducted to investigate the relevance of BMI1 in metastatic prost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2d2cfc4e83664dae1512225cef3555
https://europepmc.org/articles/PMC6295260/

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Abstract 1586: Developing novel inhibitors of S100A4 for neuroendocrine (NE) and metastatic prostate cancer: systematic testing using relevant models and drug development techniques

Autor: Syed Umbreen, Reihana Maqbool, Firdous A. Beigh, Mohammad Saleem, Badrinath R. Konety, Arsheed A. Ganaie, Natalya G. Dulyaninova

Publikováno v: Cancer Research. 77:1586-1586

S100A4, a calcium binding protein has been well studied as a marker of fibrosis and metastasis. We recently showed that in addition of being a metastatic marker, S100A4 is in fact an oncogene that plays an important role in the development of prostat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e403e867b76c713dcdaeb24264362baf
https://doi.org/10.1158/1538-7445.am2017-1586

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