Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Syed Nazreen"'
Autor:
Thikryat Neamatallah, Azizah M. Malebari, Abdulmohsin J. Alamoudi, Syed Nazreen, Mohammad Mahboob Alam, Hawazen H. Bin-Melaih, Osama A. Abuzinadah, Shaimaa M. Badr-Eldin, Gharam Alhassani, Lamar Makki, Mohammed Z. Nasrullah
Publikováno v:
Drug Delivery, Vol 30, Iss 1 (2023)
AbstractAndrographolide (AG), a major active constituent of Andrographis paniculata, is known to hinder proliferation of several types of cancer cells. However, its poor solubility and cellular permeability restrict its use in clinical applications.
Externí odkaz:
https://doaj.org/article/e5804929d2874002b9b622493e53c77d
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1116-1123 (2020)
Thymidylate synthase (TS) has been an attention-grabbing area of research for the treatment of cancers due to their role in DNA biosynthesis. In the present study, we have synthesised a library of thiazolidinedione-1,3,4-oxadiazole hybrids as TS inhi
Externí odkaz:
https://doaj.org/article/dde8a52c122b40dab2682605bcecf348
Autor:
Syed Nazreen, Abdulraheem S. A. Almalki, Serag Eldin I. Elbehairi, Ali A. Shati, Mohammad Y. Alfaifi, Ahmed A. Elhenawy, Nawaf I. Alsenani, Anas Alfarsi, Abdulrahman Alhadhrami, Esam A. Alqurashi, Mohammad Mahboob Alam
Publikováno v:
Molecules, Vol 27, Iss 20, p 6899 (2022)
In the current study, new benzimidazole-based 1,3,4-oxadiazole derivatives have been synthesized and characterized by NMR, IR, MS, and elemental analysis. The final compounds were screened for cytotoxicity against MDA-MB-231, SKOV3, and A549 cell lin
Externí odkaz:
https://doaj.org/article/b5e0884dba2e4d2d8776ea9257b6f0f5
Autor:
Syed Nazreen, Mohammad Sarwar Alam, Hinna Hamid, Abhijeet Dhulap, Mohammad Mahboob Alam, Sameena Bano, Saqlain Haider, Mohammad Ali, K.K. Pillai
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 7, Pp 1260-1267 (2019)
Phytochemical investigation of the antidiabetic chloroform fraction of the ethanolic extract obtained from the aerial parts of Callistemon lanceolatus DC led to the isolation of three new phytoconstituents, one flavone, 8-(1″-hydroxyisopranyl)-5,6-
Externí odkaz:
https://doaj.org/article/8430038e51214768b3700cc8de81726d
Publikováno v:
Nanomaterials, Vol 12, Iss 4, p 664 (2022)
Cancer and microbial infections constitute a major burden and leading cause of death globally. The development of therapeutic compounds from natural products is considered a cornerstone in drug discovery. Therefore, in the present study, the ethanoli
Externí odkaz:
https://doaj.org/article/0e11c9cd804f4036830d391c6eeecf92
Autor:
Mohammad Mahboob Alam, Syed Nazreen, Abdulraheem S. A. Almalki, Ahmed A. Elhenawy, Nawaf I. Alsenani, Serag Eldin I. Elbehairi, Azizah M. Malebari, Mohammad Y. Alfaifi, Meshari A. Alsharif, Sulaiman Y. M. Alfaifi
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 870 (2021)
A library of novel naproxen based 1,3,4-oxadiazole derivatives (8–16 and 19–26) has been synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized hybrids, compound2-(4-((5-((S)-1-(2-methoxynaphthalen-6-yl)ethyl)-1,3,4-o
Externí odkaz:
https://doaj.org/article/61b885d600f24fafa5e8d2b962a28739
Autor:
Abdulraheem S. A. Almalki, Syed Nazreen, Azizah M. Malebari, Nada M. Ali, Ahmed A. Elhenawy, Abdullah A. A. Alghamdi, Abrar Ahmad, Sulaiman Y. M. Alfaifi, Meshari A. Alsharif, Mohammad Mahboob Alam
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 866 (2021)
A library of 1,2,3-triazole-incorporated thymol-1,3,4-oxadiazole derivatives (6–18) hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8, 9, 10, and 11 exhibited significant antiproliferative activity. Among th
Externí odkaz:
https://doaj.org/article/771ff17a5778413eac5def2e47fc73b6
Autor:
Mohammad Mahboob Alam, Abdulraheem SA Almalki, Thikryat Neamatallah, Nada M. Ali, Azizah M. Malebari, Syed Nazreen
Publikováno v:
Pharmaceuticals, Vol 13, Iss 11, p 390 (2020)
Thymidylate synthase (TS) has emerged as a hot spot in cancer treatment, as it is directly involved in DNA synthesis. In the present article, nine hybrids containing 1,2,3-triazole and 1,3,4-oxadiazole moieties (6–14) were synthesized and evaluated
Externí odkaz:
https://doaj.org/article/3c85d06ddd29460e94477c5183dcd625
Publikováno v:
Advances in Pharmacology and Pharmacy. 11:156-167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a24d83f5a23dedacfd6a5ccae0e207ef
https://doi.org/10.13189/app.2023.110207
https://doi.org/10.13189/app.2023.110207
Autor:
Mohammad Mahboob Alam, Serag Eldin I. Elbehairi, Ali A. Shati, Rania A. Hussien, Mohammad Y. Alfaifi, Azizah M. Malebari, Mohammad Asad, Ahmed A. Elhenawy, Abdullah M. Asiri, Ali M. Mahzari, Reem F. Alshehri, Syed Nazreen
Publikováno v:
New Journal of Chemistry. 47:5021-5032
We report the preparation and cytotoxicity of two new eugenol derivatives that contain 1,3,4-oxadiazole, as novel inhibitors of thymidylate synthase; these derivatives are shown to be promising chemotherapeutic agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5e2ad1390a0ad4c70b91fe895c21fe6
https://doi.org/10.1039/d2nj05711e
https://doi.org/10.1039/d2nj05711e