Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Syed M. Naseem"'
Autor:
Syed M. Naseem
Publikováno v:
Toxicology and Applied Pharmacology. 141:49-58
This study evaluated the toxicokinetics of a saxitoxin (STX)analog, [3H]saxitoxinol (STXOL), in rats. [3H]saxitoxinol (18.9 μCi/kg body weight) was administered iv to male Wistar rats via the penile vein. After injection, [3H]STXOL disappeared rapid
Autor:
Syed M. Naseem
Publikováno v:
Journal of Asian Economics. 15:205-207
Publikováno v:
Journal of Biochemical Toxicology. 7:133-138
Ricin toxin, which consists of two distinct polypeptide moieties, A and B chains, is cytotoxic to the cultured macrophage cell line, J774A.1. Ricin is a protein synthesis inhibitor, and incubating macrophages for 4 hours with ricin (1 pM to 10 nM) in
Publikováno v:
Toxicology in Vitro. 5:341-345
The effects of microcystin-LR, a trichothecene, T-2 and saxitoxin on membrane lipid mediators of inflammatory processes were evaluated in cultured rat hepatocytes using [(14)C]arachidonic acid. Microcystin-LR significantly stimulated the release of p
Autor:
Syed M. Naseem
Publikováno v:
Journal of Asian Economics. 27:87-88
Autor:
Donald A. Creasia, Syed M. Naseem
Publikováno v:
Biochemistry and molecular biology international. 41(2)
The binding characteristics of saxitoxin (STX), a known voltage-gated sodium channel blocker, and its analog saxitoxinol (STXOL), were studied in neuroblastoma, peritoneal macrophage, hepatocytes and PC-12 cell lines. 3H-STXOL bound to the cell-surfa
Publikováno v:
Journal of analytical toxicology. 19(3)
High-performance liquid chromatography (HP/C) was used to separate, identify, and quantitate the trichothecin mycotoxin, T-2 (4~,15-diacetoxy-30c-hydroxy-8oc [3-methyl-butyryloxy]-I 2,13epoxy Ag-trichothecin), and its metabolites in plasma and urine
Autor:
Syed M. Naseem, Judith G. Pace
Publikováno v:
Journal of biochemical toxicology. 8(3)
The toxicity of ricin in susceptible cells is well characterized biochemically, but the pathophysiological implications of its toxicity and the immune response to ricin challenge in the lung are unknown. Incubating macrophage cell line with ricin (1
Publikováno v:
Toxicon : official journal of the International Society on Toxinology. 31(7)
Tritiated saxitoxinol was used to obtain preliminary information on saxitoxin metabolism in the rat. Sublethal doses of tritiated saxitoxinol (18.9-microCi/kg; 3.8 micrograms/kg) were injected i.v. into each of six rats. Urine and fecal samples were
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 195(3)
We showed previously that exposure to microcystin causes eicosanoid release. That study was extended further to test the effect of glucocorticoids on microcystin-induced release of [14C]arachidonic acid and its metabolites from rat hepatocytes previo