Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency

Autor: Katharina Hahn, Liart Pollmann, Juliette Nowak, Ariane Hai Ha Nguyen, Kathrin Haake, Anna-Lena Neehus, Syed F. Hassnain Waqas, Frank Pessler, Ulrich Baumann, Miriam Hetzel, Jean-Laurent Casanova, Ansgar Schulz, Jacinta Bustamante, Mania Ackermann, Nico Lachmann

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 785-795 (2020)

Autosomal recessive (AR) complete interferon-γ receptor 1 (IFN-γR1) deficiency, also known as one genetic etiology of Mendelian susceptibility to mycobacterial disease (MSMD), is a life-threatening congenital disease leading to premature death. Aff

Externí odkaz: https://doaj.org/article/402b38c898664b7e8e2c466f01b1aa11

Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Autor: Ahmed M. Elsaman, Mathias Müsken, Peter Braubach, Felix Meissner, Jana Zeitvogel, Zeinab Abu-Elbaha Gouda, Bernd Auber, Gisa Gerold, Matthias Schefzyk, Ulrich Martin, Lennart M. Roesner, Muhammad Nasir Hayat Malik, Sylvia Merkert, Ahmed R. Radwan, Frank Pessler, Robert Geffers, Jingyuan Cheng, Sven Schuchardt, Thomas Werfel, Ruth Olmer, Syed F. Hassnain Waqas

Publikováno v: The Journal of clinical investigation
United States
Journal of Clinical Investigation
The Journal of Clinical Investigation

Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59af2dd35f4d8513c4488602555f8d50
https://hdl.handle.net/10033/623136

Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse

Autor: Anh Cuong Hoang, Syed F. Hassnain Waqas, Grace Ampem, Tamás Röszer, Matthew Guille, Anna Noble, Sarah Strauß, Manuela Popp

Publikováno v: Journal of Leukocyte Biology
Hassnain Waqas, S F, Noble, A, Hoang, A C, Ampem, G, Popp, M, Strauß, S, Guille, M & Röszer, T 2017, ' Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse ', Journal of Leukocyte Biology, vol. 102, no. 3, jlb.1A0317-082RR, pp. 845-855 . https://doi.org/10.1189/jlb.1A0317-082RR

ATMs develop from early myeloid progenitors, allowing monocyte‐independent ATM replenishment.
ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72beb0453707b21e9d737de54a5344d7
http://europepmc.org/articles/PMC5574031

Analysis of IL-4/STAT6 Signaling in Macrophages

Autor: Grace Ampem, Tamás Röszer, Syed F. Hassnain Waqas

Publikováno v: Methods in Molecular Biology ISBN: 9781493991945

Activation of signal transducer and activator of transcription 6 (STAT6) is a key signaling pathway in macrophage function, and is required for the so-called alternative (M2) activation of macrophages. Interleukin (IL)-4 and IL-13 are important M2 po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::291b11bf42772df201b7cf17169a6c3a
https://doi.org/10.1007/978-1-4939-9195-2_17

Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse.

Autor: Hassnain Waqas, Syed F., Noble, Anna, Hoang, Anh C., Ampem, Grace, Popp, Manuela, Strauß, Sarah, Guille, Matthew, Röszer, Tamás

Publikováno v: Journal of Leukocyte Biology; Sep2017, Vol. 102 Issue 3, p845-855, 11p