Výsledky vyhledávání - "Sydney Spector"

Abstract 2325: Targeting kynurenine pathway using novel IDO/TDO dual inhibitor (AT0174) to modulate tumor microenvironment in platinum resistant non-small cell lung cancer cancer: An immunometabolism compliment markers

Autor: Sydney Spector, Chunjing Wu, Dan Nguyen, George Theodore, Ashley Garcia, Lynn Feun, Niramol Savaraj, Medhi Wangpaichitr

Publikováno v: Cancer Research. 82:2325-2325

We discovered a crucial change common to all platinum resistant (CR) NSCLC cells, wherein a high level of reactive oxygen species (ROS) modulates tumor metabolism. CR cells activate the kynurenine (KYN) pathway (KP) during excessive oxidative stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::025fc5e95634cd6619cf1dc6e9500c5d
https://doi.org/10.1158/1538-7445.am2022-2325

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Pharmacological characterization of morphine-6-sulfate and codeine-6-sulfate

Autor: Elizabeth Bolan, Gavril W. Pasternak, Sydney Spector, Tomas de Paulis, Dennis E. Schmidt, Amy Zuckerman

Publikováno v: Brain Research. 842:1-5

Morphine-6-sulfate (M6S) and codeine-6-sulfate (C6S) are mu-selective opiates which have been isolated from brain. M6S is an effective analgesic, with a 30-fold greater potency than morphine in the mouse radiant heat tailflick assay and similar to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e3cf3ec4f431fdadb56fcef20bfe9d
https://doi.org/10.1016/s0006-8993(99)01766-7

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Endogenous codeine: Autocrine regulator of catecholamine release from chromaffin cells

Autor: Jack E. Brinn, Sydney Spector, August Epple, Barbara Nibbio

Publikováno v: Life Sciences. 54:695-702

In addition to the catecholamines (CAs) dopamine (DA), norepinephrine (NE) and epinephrine (E), perifused chromaffin cells of the eel secrete codeine and morphine. In controls, the release of NE and E is strongly correlated, while there is no correla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bd8b65f991eef99629d4cbd2d4d5a7
https://doi.org/10.1016/0024-3205(94)90157-0

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Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression

Autor: Naji N. Abumrad, Michael K. Leung, Thomas V. Bilfinger, George B. Stefano, Berta Scharrer, Maynard H. Makman, Alex Digenis, Sydney Spector

Publikováno v: Proceedings of the National Academy of Sciences. 90:11099-11103

The presence of morphine-like and codeine-like substances was demonstrated in the pedal ganglia, hemolymph, and mantle tissues of the mollusc Mytilus edulis. The pharmacological activities of the endogenous morphine-like material resemble those of au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d406eae443ce2d8fdf4f270b0fd516f
https://doi.org/10.1073/pnas.90.23.11099

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Endogeneous morphine and codeine in mice — effect of muramyl dipeptide

Autor: Pavel Horàk, Frank Haberman, Sydney Spector

Publikováno v: Life Sciences. 52:PL255-PL260

Administration of morphine exerts many effects on the immune system. On the other hand little attention has been paid to the fact, that endogenous morphine and codeine exists in mammals, including man. This raises the question, whether or not endogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943c6053844a71b01bf574f1a10aaf24
https://doi.org/10.1016/0024-3205(93)90011-q

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Endogenous morphine and codeine: Release by the chromaffin cells of the eel

Autor: August Epple, Sydney Spector, Pavel Horak, Isabel Navarro

Publikováno v: ResearcherID

Both the adrenomedullary equivalent and the plasma of the American eel ( Anguilla rostrata ) contain endogenous morphine and codeine. The opiate concentrations are similar to those found in the rat adrenal and human plasma, respectively. The adrenal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8653cc335284d48297d33b6b7ac101b
https://doi.org/10.1016/0024-3205(93)90175-3

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Endogenous Benzodiazepine Receptor Ligands in Human and Animal Hepatic Encephalopathy

Autor: Erminio Costa, Alessandro Guidotti, Richard J. Weber, M.L. Zeneroli, Steven M. Paul, Mario Baraldi, Jeffrey D. Rothstein, Marjut Olasmaa, Sydney Spector

Publikováno v: Journal of Neurochemistry. 55:2015-2023

The role of endogenous benzodiazepine receptor ligands in the pathogenesis of hepatic encephalopathy was studied in humans and in rat models of hepatic encephalopathy. Endogenous benzodiazepine ligands were extracted from rat brain and human CSF by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646f9d7e53b88279d44260b0f56247a4
https://doi.org/10.1111/j.1471-4159.1990.tb05790.x

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Peripheral-Acting Benzodiazepines Inhibit the Growth of Human Melanoma Cells and Potentiate the Antiproliferative Activity of Recombinant Human Interferons

Autor: Sidney Pestka, Paul B. Fisher, R. Ian Fryer, Sydney Spector, Wendy E. Solowey

Publikováno v: Journal of Interferon Research. 10:269-280

In this study, we evaluated the effect of a series of peripheral-acting benzodiazepines (BZDs), alone and in combination with recombinant human leukocyte (IFN-alpha A), fibroblast (IFN-beta), or immune (IFN-gamma) interferon (IFN), on the growth of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606f233bd9f9887f8884237c2ae0a433
https://doi.org/10.1089/jir.1990.10.269

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