Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sydney S. Jellison"'
Autor:
Takehiko Yamanashi, Takaaki Nagao, Nadia E. Wahba, Pedro S. Marra, Kaitlyn J. Crutchley, Alissa A. Meyer, Ally J. Andreasen, Mandy M. Hellman, Sydney S. Jellison, Christopher G. Hughes, Pratik P. Pandharipande, Matthew A. Howard, III, Hiroto Kawasaki, Masaaki Iwata, Marco M. Hefti, Gen Shinozaki
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The pathophysiological mechanisms of postoperative delirium (POD) are still not clear, and no reliable biomarker is available to differentiate those with and without POD. Pre- and post-surgery blood from epilepsy subjects undergoing neurosur
Externí odkaz:
https://doaj.org/article/8a3abd4453304a7f85d9d7d32ab30baf
Autor:
Gen Shinozaki, Patricia R. Braun, Benjamin W. Q. Hing, Andrew Ratanatharathorn, Mason J. Klisares, Gabrielle N. Duncan, Sydney S. Jellison, Jonathan T. Heinzman, Yasunori Nagahama, Liesl Close, Sayeh Sabbagh, Brian J. Dlouhy, Matthew A. Howard, Hiroto Kawasaki, Hyunkeun R. Cho
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Background: Delirium in elderly patients is common and dangerous. Major risk factors include aging and exogenous insults, such as infection or surgery. In animal models, aging enhances pro-inflammatory cytokine release from microglia in response to e
Externí odkaz:
https://doaj.org/article/a789382ad31a4071a98422849b73f06d
Autor:
Gloria Chang, Taku Saito, Srishti Mathur, Masaaki Iwata, Eleanor J. Sullivan, Takehiko Yamanashi, Gen Shinozaki, Aihide Yoshino, Pedro S. Marra, Nadia E. Wahba, Hiroyuki Toda, Pratik P. Pandharipande, Tong Yu, Zoe-Ella M. Anderson, Koichi Kaneko, Alexandra Alario, Sangil Lee, Sydney S. Jellison, Alissa A. Meyer, Kaitlyn J. Crutchley
Publikováno v:
Neurobiology of Aging. 105:310-317
It has been suggested that aging and inflammation play key roles in the development of delirium. In the present study, we investigated the differences of the DNAm patterns in the TNF gene between patients with delirium and without. The data and sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cfc2fefe8ba8245762744226e8c007
https://doi.org/10.1016/j.neurobiolaging.2021.05.005
https://doi.org/10.1016/j.neurobiolaging.2021.05.005
Autor:
Takehiko Yamanashi, Zoe-Ella EM Anderson, Manisha Modukuri, Gloria Chang, Tammy Tran, Pedro S. Marra, Nadia E. Wahba, Kaitlyn J. Crutchley, Eleanor J. Sullivan, Sydney S. Jellison, Katie R. Comp, Cade C. Akers, Alissa A. Meyer, Sangil Lee, Masaaki Iwata, Hyunkeun R. Cho, Eri Shinozaki, Gen Shinozaki
Publikováno v:
Aging. 14(22)
Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality.In this retrospective cohort s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765abfa7eb34db8541258cbf4e2f9374
https://pubmed.ncbi.nlm.nih.gov/36399107
https://pubmed.ncbi.nlm.nih.gov/36399107
Autor:
Takehiko Yamanashi, Zoe-Ella EM Anderson, Manisha Modukuri, Gloria Chang, Tammy Tran, Pedro S. Marra, Nadia E. Wahba, Kaitlyn J. Crutchley, Eleanor J. Sullivan, Sydney S. Jellison, Katie R. Comp, Cade C. Akers, Alissa A. Meyer, Sangil Lee, Masaaki Iwata, Hyunkeun R. Cho, Eri Shinozaki, Gen Shinozaki
ObjectiveTo investigate the relationship between history of metformin use and delirium risk, as well as long-term mortality.MethodsIn this retrospective cohort study, subjects recruited between January 2016 and March 2020 were analyzed. Logistic regr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090087231705447f292875e391ee93dd
https://doi.org/10.1101/2022.04.03.22273209
https://doi.org/10.1101/2022.04.03.22273209
Autor:
Eri Shinozaki, Allison J. Andreasen, Sophia Daniel, Hyunkeun Ryan Cho, Lydia R Leyden, Hiroyuki Toda, Taku Saito, Gen Shinozaki, Gabrielle N. Duncan, Mandy M. Hellman, Sangil Lee, Sydney S. Jellison, Aihide Yoshino, Tong Yu, Mason J. Klisares
Publikováno v:
J Psychiatr Res
Previously our study has shown that the DNA methylation (DNAm) levels at CpG sites in the pro-inflammatory cytokine gene, TNF-alpha, decrease along with aging, suggesting the potential role of DNAm in aging and heightened inflammatory process leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c6a7bdc2f4e9bc57e5fc67312beb40
https://doi.org/10.1016/j.jpsychires.2020.06.005
https://doi.org/10.1016/j.jpsychires.2020.06.005
Autor:
Liesl N. Close, Benjamin Hing, Hiroto Kawasaki, Mason J. Klisares, Yasunori Nagahama, Patricia Braun, Sydney S. Jellison, Kumi Yuki, Gen Shinozaki, Mai Tanaka-Sahker, Yaseen Shabbir, Kyle M. Stein, Brian J. Dlouhy, Ellyn M. Cramer, Sayeh Sabbagh, Gabrielle N. Duncan, Lindsey N. Gaul, James B. Potash, Jonathan T. Heinzman, Matthew A. Howard, Julian Robles, Aubrey C. Chan
Publikováno v:
Psychiatry Clin Neurosci
Aim Glucocorticoids play a major role in regulating the stress response, and an imbalance of glucocorticoids has been implicated in stress-related disorders. Within mouse models, CpGs across the genome have been shown to be differentially methylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa94d9d7eb9b04f0b28a4ea2137edf4
https://doi.org/10.1111/pcn.12835
https://doi.org/10.1111/pcn.12835
Autor:
Taku Saito, Hyunkeun Ryan Cho, Aihide Yoshino, Gen Shinozaki, Patricia Braun, Eri Shinozaki, Mandy M. Hellman, Sophia Daniel, Hiroyuki Toda, Sydney S. Jellison, Sangil Lee
Publikováno v:
Neurobiol Aging
We previously reported the association between DNA methylation (DNAm) of pro-inflammatory cytokine genes and age. In addition, neurotrophic factors are known to be associated with age and neurocognitive disorders. Therefore, we hypothesized that DNAm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876806c7202f8db173ccefb11320cc04
https://europepmc.org/articles/PMC7444651/
https://europepmc.org/articles/PMC7444651/
Autor:
Patricia Braun, Eri Shinozaki, Sangil Lee, Sydney S. Jellison, Gen Shinozaki, Sophia Daniel, Taku Saito, Aihide Yoshino, Hiroyuki Toda, Hyunkeun Ryan Cho, Mandy M. Hellman
INTRODUCTIONWe previously reported the association between DNA methylation (DNAm) of pro-inflammatory cytokine genes and aging. Neurotrophic factors are also known to be associated with aging and neurocognitive disorders. Thus, we hypothesized that D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bcccbba5dd6265547d9aa9f480e150
https://doi.org/10.1101/730382
https://doi.org/10.1101/730382
Autor:
Sophia Daniel, Sydney S. Jellison, Lydia R Leyden, Taku Saito, Hiroyuki Toda, Eri Shinozaki, Mandy M. Hellman, Gen Shinozaki, Allison J. Andreasen, Mason J. Klisares, Tong Yu, Gabrielle N. Duncan, Hyunkeun Ryan Cho, Sangil Lee, Aihide Yoshino
BackgroundThe authors previously hypothesized the role of epigenetics in pathophysiology of delirium, and tested DNA methylation (DNAm) change among pro-inflammatory cytokines along with aging in blood, glia and neuron. The authors reported that DNAm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3f69c2d36d2de90c6c24e797c6b26b
https://doi.org/10.1101/729335
https://doi.org/10.1101/729335