Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sydney R Coffey"'
Autor:
Seth A Ament, Jocelynn R Pearl, Jeffrey P Cantle, Robert M Bragg, Peter J Skene, Sydney R Coffey, Dani E Bergey, Vanessa C Wheeler, Marcy E MacDonald, Nitin S Baliga, Jim Rosinski, Leroy E Hood, Jeffrey B Carroll, Nathan D Price
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 3, Pp 1-16 (2018)
Abstract Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcri
Externí odkaz:
https://doaj.org/article/37a0a3de07ca4d86ab89638ff4d313a8
Autor:
Sydney R Coffey, Robert M Bragg, Shawn Minnig, Seth A Ament, Jeffrey P Cantle, Anne Glickenhaus, Daniel Shelnut, José M Carrillo, Dominic D Shuttleworth, Julie-Anne Rodier, Kimihiro Noguchi, C Frank Bennett, Nathan D Price, Holly B Kordasiewicz, Jeffrey B Carroll
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175968 (2017)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease whose predominant neuropathological signature is the selective loss of medium spiny neurons in the striatum. Despite this selective neuropathology, the mutant protein (hunti
Externí odkaz:
https://doaj.org/article/51be1c48c7b241a8b7a44ebe739c65ac
Autor:
Xiaonan Zhao, Cassandra McHugh, Sydney R. Coffey, Diego Antonio Jimenez, Elizabeth Adams, Jeffrey B. Carroll, Karen Usdin
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 5 (2022)
Repeat expansion diseases are a large group of human genetic disorders caused by expansion of a specific short tandem repeat tract. Expansion in somatic cells affects age of onset and disease severity in some of these disorders. However, alleles in D
Externí odkaz:
https://doaj.org/article/d0e15aa95ee9410097e86929425b5683
Autor:
Sydney R. Coffey, Brian R. Herb, Carlo Colantuoni, Seth A. Ament, Sonia Malaiya, Marcia Cortes-Gutierrez, Jeffrey B. Carroll, Samuel R. W. Legg, Jeffrey P. Cantle
Publikováno v:
J Neurosci
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs primarily in striatal medium spiny neurons (MSNs), but the involvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cca2032da9fe1918c9f6d7cfac3c969
https://doi.org/10.1523/jneurosci.2074-20.2021
https://doi.org/10.1523/jneurosci.2074-20.2021
Autor:
Holly B. Kordasiewicz, Vanessa C. Wheeler, Marissa A Andrew, Michael Flower, Deanna Marchionini, Seung Kwak, José M. Carrillo, Cassandra A. McHugh, Heather Ging, Robert M. Bragg, Julie-Anne Rodier, Jeffrey P. Cantle, Sydney R. Coffey, Scott Zeitlin, David Howland, Hilary Wilkinson, C. Frank Bennett, Ricardo Mouro Pinto, Marina Kovalenko, Sarah J. Tabrizi, Georg Auburger, Joseph Hamilton, Jeffrey B. Carroll
Expanded trinucleotide repeats cause many human diseases, including Huntington’s disease (HD). Recent studies indicate that somatic instability of these repeats contributes to pathogenesis in several expansion disorders. We find that lowering hunti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d6223761933271ca2f891e8b36eb09c
https://doi.org/10.1101/2020.07.23.218347
https://doi.org/10.1101/2020.07.23.218347
Autor:
Seth A. Ament, Dani E Bergey, Jeffrey P. Cantle, Jocelynn R. Pearl, Robert M. Bragg, Leroy Hood, Amol C. Shetty, Nathan D. Price, Holly B. Kordasiewicz, Jeffrey B. Carroll, Sydney R. Coffey
SummaryProgressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington’s disease (HD), but direct relationships between the huntingtin (HTT) protein and chromatin remain poorly described. Here, using ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0cb3f112b2fdd6dadad67140db4576
https://doi.org/10.1101/2020.06.04.132571
https://doi.org/10.1101/2020.06.04.132571
Autor:
Sydney R. Coffey, Robert M. Bragg, Nagana Gowda, Jeffrey P. Cantle, Daniel Raftery, Nelly Panté, Jeff Carroll
Publikováno v:
Models for HD.
Background While Huntington’s disease (HD) is classically considered a neurological disorder, effects of the CAG repeat expansion in huntingtin (Htt) are not limited to the brain. HD patients experience a range of somatic signs including metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67fb50d4284ba37cb7ce009bae7fad6d
https://doi.org/10.1136/jnnp-2018-ehdn.53
https://doi.org/10.1136/jnnp-2018-ehdn.53
Autor:
Sydney R. Coffey, Marcy E. MacDonald, Jeffrey P. Cantle, Jocelynn R. Pearl, Seth A. Ament, Nathan D. Price, Jeffrey B. Carroll, Peter J Skene, Nitin S. Baliga, Leroy Hood, Robert M. Bragg, Dani E Bergey, Jim Rosinski, Vanessa C. Wheeler
Publikováno v:
Molecular Systems Biology
Transcriptional changes occur presymptomatically and throughout Huntington9s disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267eb255bc8c1cf32802eabb97f7f88a
https://doi.org/10.15252/msb.20167435
https://doi.org/10.15252/msb.20167435
Autor:
William S. Hovander, Sydney R. Coffey, Hardeep S. Tiwana, Madeline Hamilton, Shawn Minnig, Samuel R. W. Legg, Robert M. Bragg, Eva-Mari S. Vik, Dominic D. Shuttleworth, Jeffrey B. Carroll, Jeffrey P. Cantle, Wes T. Solem
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Apathy is one of the most prevalent and progressive psychiatric symptoms in Huntington’s disease (HD) patients. However, preclinical work in HD mouse models tends to focus on molecular and motor, rather than affective, phenotypes. Measuring behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a951b5bbd18c339565ac38feb94f3bcf
https://doi.org/10.1038/s41598-018-20607-7
https://doi.org/10.1038/s41598-018-20607-7
Autor:
Robert M. Bragg, Sydney R. Coffey, Rory M. Weston, Seth A. Ament, Jeffrey P. Cantle, Shawn Minnig, Cory C. Funk, Dominic D. Shuttleworth, Emily L. Woods, Bonnie R. Sullivan, Lindsey Jones, Anne Glickenhaus, John S. Anderson, Michael D. Anderson, Stephen B. Dunnett, Vanessa C. Wheeler, Marcy E. MacDonald, Simon P. Brooks, Nathan D. Price, Jeffrey B. Carroll
Publikováno v:
Scientific Reports. 7
Scientific Reports 7: Article number: 41570; published online: 08 February 2017; updated: 28 March 2017 This Article contains a typographical error in the Methods section, under the subheading “Library construction, RNA Sequencing and RNASeq analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1496f6ddb4740ddb933aa001eac951fa
https://doi.org/10.1038/srep44960
https://doi.org/10.1038/srep44960