Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sydney L. Campbell"'
Autor:
Matthew E. Bechard, Rana Smalling, Akimasa Hayashi, Yi Zhong, Anna E. Word, Sydney L. Campbell, Amanda V. Tran, Vivian L. Weiss, Christine Iacobuzio-Donahue, Kathryn E. Wellen, Oliver G. McDonald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Distant metastases from pancreatic cancer patients were previously reported by the authors to be dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Here the authors report a novel metabolic adaptation that that stably
Externí odkaz:
https://doaj.org/article/4506861df93c451294cd63802d5a994b
Autor:
Steven Zhao, AnnMarie Torres, Ryan A. Henry, Sophie Trefely, Martina Wallace, Joyce V. Lee, Alessandro Carrer, Arjun Sengupta, Sydney L. Campbell, Yin-Ming Kuo, Alexander J. Frey, Noah Meurs, John M. Viola, Ian A. Blair, Aalim M. Weljie, Christian M. Metallo, Nathaniel W. Snyder, Andrew J. Andrews, Kathryn E. Wellen
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1037-1052 (2016)
Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy production, lipid metabolism, and epigenomic modifications. Here, we sh
Externí odkaz:
https://doaj.org/article/1368c98dfbae4b1085e1112de5ae4ed8
Autor:
Kathryn E. Wellen, Ben Z. Stanger, Nathaniel W. Snyder, Benjamin A. Garcia, Alessandro Gardini, Marco Trizzino, Yogev Sela, Shaun Egolf, Sharanya Sivanand, Hayley C. Affronti, Joshua L.D. Parris, Simone Sidoli, Kollin C. Schultz, Robert J. Norgard, Sydney L. Campbell, Steven Zhao, Sophie Trefely, Alessandro Carrer
Figures S1-S7 and Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224b8fe602dcdfae5be3cb3ac813063a
https://doi.org/10.1158/2159-8290.22532489.v1
https://doi.org/10.1158/2159-8290.22532489.v1
Autor:
Anna E Word, Matthew E. Bechard, Yi Zhong, Amanda V. Tran, Sydney L. Campbell, Oliver G. McDonald, Akimasa Hayashi, Vivian L. Weiss, Christine A. Iacobuzio-Donahue, Rana V Smalling, Kathryn E. Wellen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Although metastasis is the most common cause of cancer deaths, metastasis-intrinsic dependencies remain largely uncharacterized. We previously reported that metastatic pancreatic cancers were dependent on the glucose-metabolizing enzyme phosphoglucon
Autor:
Ian A. Blair, Kathryn Sun, Sydney L. Campbell, Sophie Trefely, Michael Noji, Salisa Kruijning, Bethany E Schaffer, Tiffany Tsang, John Blenis, Hayley C. Affronti, Kathryn E. Wellen, Clementina Mesaros, Luke Izzo
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylat
Autor:
John Blenis, Ian A. Blair, Hayley C. Affronti, Kathryn E. Wellen, Michael Noji, Kathryn Sun, Sydney L. Campbell, Bethany E Schaffer, Salisa Kruijning, Sophie Trefely, Tiffany Tsang, Luke Izzo, Clementina Mesaros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a686d8814cb3b93b3271bf828b6df7
https://doi.org/10.7554/elife.62644.sa2
https://doi.org/10.7554/elife.62644.sa2
Autor:
Hayley C. Affronti, Gleb A. Bazilevsky, Xuepeng Wei, Ronen Marmorstein, Sydney L. Campbell, Kathryn E. Wellen
Publikováno v:
J Biol Chem
ATP-citrate lyase (ACLY) is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes. ACLY is aberrantly regulated in many cancers, cardiovascular disease, and metabolic disorders. However, the mol
Autor:
Kathryn E. Wellen, Rizwan Saffie, Nan Zhou, Delphine Rolland, Sydney L. Campbell, Luca Busino, Brian C. Capell, Venkatesha Basrur, Özlem Önder, Kojo S.J. Elenitoba-Johnson
Publikováno v:
Cancer Res
Mature B-cell neoplasms are the fifth most common neoplasm. Due to significant heterogeneity at the clinical and genetic levels, current therapies for these cancers fail to provide long-term cures. The clinical success of proteasome inhibition for th
Autor:
Helen Jiang, Kevin A. Janssen, Caroline Perry, Patrick M. Schaefer, Prasanth Potluri, Piotr K. Kopinski, Kathryn E. Wellen, Douglas C. Wallace, Larry N. Singh, Benjamin A. Garcia, Nathaniel W. Snyder, Mary T. Doan, Sophie Trefely, Eiko Nakamaru-Ogiso, Kelly R. Karch, Itzhak Nissim, Sydney L. Campbell, Jesus A Tintos-Hernandez
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mitochondrial DNA (mtDNA) mutations have been associated with common metabolic and degenerative disease phenotypes, implying a bioenergetic etiology for these diseases. For example, the mtDNA tRNALeu(UUR) m.3243A > G mutation manifests a
Autor:
Sophie Trefely, Constantinos Koumenis, Anthony A. Mancuso, Hee-Woong Lim, Supriya Shah, Piotr K. Kopinski, Kyoung-Jae Won, Douglas C. Wallace, Kathryn E. Wellen, Whitney J. Carriveau, Sydney L. Campbell, Jinyang Li, Natalie A. Daurio
Publikováno v:
Oncotarget
// Supriya Shah 1 , Whitney J. Carriveau 1 , Jinyang Li 1 , Sydney L. Campbell 1 , Piotr K. Kopinski 5, 6 , Hee-Woong Lim 2 , Natalie Daurio 3 , Sophie Trefely 1 , Kyoung-Jae Won 2 , Douglas C. Wallace 5 , Constantinos Koumenis 3 , Anthony Mancuso 1,