Výsledky vyhledávání - "Sydney J. Blevins"

Killer T cells with a beta-flavi(r) for dengue

Autor: Eric S. Huseby, Sydney J. Blevins

Publikováno v: Nature Immunology. 18:1186-1188

Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a5bc3849b70f2282fc4208f88af600
https://doi.org/10.1038/ni.3833

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A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3

Autor: Brian D, Stadinski, Sydney J, Blevins, Nicholas A, Spidale, Brian R, Duke, Priya G, Huseby, Lawrence J, Stern, Eric S, Huseby

Publikováno v: Nature immunology. 20(8)

The neonatal thymus generates Foxp3(+) regulatory T (tT(reg)) cells that are critical in controlling immune homeostasis and preventing multi-organ autoimmunity. The role of antigen specificity on neonatal tT(reg) cell selection is unresolved. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62ca4c496a93bc1f4c28fbfb83d28bcf
https://pubmed.ncbi.nlm.nih.gov/31209405

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Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

Autor: Marvin H. Gee, Michael E. Birnbaum, Jarrett Adams, Brian M. Baker, David M. Kranz, Sydney J. Blevins, Leah V. Sibener, Samanthi Narayanan, K. Christopher Garcia, Sachdev S. Sidhu

Publikováno v: Nature Immunology. 17:87-94

The T cell antigen receptor (TCR)-peptide-major histocompatibility complex (MHC) interface is composed of conserved and diverse regions, yet the relative contribution of each in shaping recognition by T cells remains unclear. Here we isolated cross-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::815b6afef140eac284bbfff9d3f39501
https://doi.org/10.1038/ni.3310

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Plasticity in the Contribution of T Cell Receptor Variable Region Residues to Binding of Peptide–HLA-A2 Complexes

Autor: Sydney J. Blevins, Wolfgang Uckert, Daniel Sommermeyer, David M. Kranz, Sheena N. Smith, Brian M. Baker, Helga Bernhard, Kurt H. Piepenbrink

Publikováno v: Journal of Molecular Biology. 425:4496-4507

One hypothesis accounting for major histocompatibility complex (MHC) restriction by T cell receptors (TCRs) holds that there are several evolutionary conserved residues in TCR variable regions that contact MHC. While this "germline codon" hypothesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea89bc5081d18cdd9f81e5b3c741719
https://doi.org/10.1016/j.jmb.2013.08.007

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Using Global Analysis to Extend the Accuracy and Precision of Binding Measurements with T cell Receptors and Their Peptide/MHC Ligands

Autor: Sydney J. Blevins, Brian M. Baker

Publikováno v: Frontiers in Molecular Biosciences

In cellular immunity, clonally distributed T cell receptors (TCRs) engage complexes of peptides bound to major histocompatibility complex proteins (pMHCs). In the interactions of TCRs with pMHCs, regions of restricted and variable diversity align in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edce6ca8d77cb1f576d6c2312276a38d

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How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire

Autor: Michael I. Nishimura, Yuan Wang, Brian G. Pierce, Sydney J. Blevins, Nishant K. Singh, Timothy T. Spear, Timothy P. Riley, Zhiping Weng, Brian M. Baker

How T-cell receptors (TCRs) can be intrinsically biased toward MHC proteins while simultaneously display the structural adaptability required to engage diverse ligands remains a controversial puzzle. We addressed this by examining αβ TCR sequences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fcaf1204df7b286afb587717748d0a
https://europepmc.org/articles/PMC4780628/

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Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes

Autor: Orrin S. Belden, Yuan Wang, Timothy P. Riley, Timothy T. Spear, Lawrence J. Stern, Michael I. Nishimura, Brian M. Baker, Sydney J. Blevins, Liusong Yin, Lance M. Hellman

Publikováno v: Journal of immunological methods. 432

Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely used to assess the binding of peptides to MHC proteins, particularly within the structural immunology community. Although thermal stability assays offer advant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e126fda86adda762cce675de15f5e1
https://pubmed.ncbi.nlm.nih.gov/26906089

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