Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sydney Drury"'
Publikováno v:
Journal of Urology. 207
Autor:
Erietta Stelekati, Zhangying Cai, Sasikanth Manne, Zeyu Chen, Jean-Christophe Beltra, Lance Alec Buchness, Xuebing Leng, Svetlana Ristin, Kito Nzingha, Viktoriya Ekshyyan, Christina Niavi, Mohamed S. Abdel-Hakeem, Mohammed-Alkhatim Ali, Sydney Drury, Chi Wai Lau, Zhen Gao, Yuguang Ban, Simon K. Zhou, K. Mark Ansel, Makoto Kurachi, Martha S. Jordan, Alejandro V. Villarino, Shin Foong Ngiow, E. John Wherry
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(17)
Significance CD8 T cell exhaustion is a key underlying factor limiting immunity in chronic infections and cancer. Persistent antigen exposure antagonizes formation of functional memory CD8 T cells that provide long-term protection and, instead, drive
Autor:
Martha S Jordan, Sydney Drury, Josephine R Giles, Sasikanth Manne, Hua Huang, Zeyu Chen, Derek Oldridge, E. John Wherry, Amy E Baxter
Publikováno v:
The Journal of Immunology. 206:14.07-14.07
CD8 T cells are critical for clearing infections and immune surveillance of cancers. However, in the setting of chronic viral infections and tumor growth, CD8 T cells become exhausted. T cell exhaustion (TEX) is characterized by a progressive increas