Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sydney C. D'Souza"'
Autor:
Himanshu Gupta, Sima Chaudhari, Ayushi Rai, Smitha Bhat, Pratima K Sahu, Manjunath H Hande, Sydney C D'Souza, Umakanth Shashikiran, Kapaettu Satyamoorthy
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175702 (2017)
Multiple mechanisms such as genetic and epigenetic variations within a key gene may play a role in malarial susceptibility and response to anti-malarial drugs in the population. ABCB1 is one of the well-studied membrane transporter genes that code fo
Externí odkaz:
https://doaj.org/article/56a4d610ec7f491b99dfb6fa03200034
Autor:
Nagaraja M Phani, Prabha Adhikari, Shivashankara K Nagri, Sydney C D'Souza, Kapaettu Satyamoorthy, Padmalatha S Rai
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157364 (2016)
AIM:Several genetic variants for type 2 diabetes (T2D) have been identified through genome wide association studies (GWAS) from Caucasian population; however replication studies were not consistent across various ethnicities. Objective of the current
Externí odkaz:
https://doaj.org/article/006b368a559e41abb4786115fcdb6daa
Autor:
Padmalatha S. Rai, Ananth Kakar, Shashikiran Umakanth, Nagaraja M. Phani, Shivashankara K. Nagri, Kapaettu Satyamoorthy, Manik Vohra, Sydney C. D’Souza, Prabha Adhikari
Publikováno v:
Pharmacogenomics. 19:905-911
Aim: Metformin, an oral hypoglycemic drug is the first line of treatment for Type 2 diabetes individuals. We studied the effect of critical gene single nucleotide polymorphisms on the glucose lowering effect of metformin. Method: We performed a prosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3881604fb93f25940c4acb4c20b51386
https://doi.org/10.2217/pgs-2018-0041
https://doi.org/10.2217/pgs-2018-0041
Autor:
Manik Vohra, Shivashankara K. Nagri, Padmalatha S. Rai, Nagaraja M. Phani, Sydney C. D’Souza, Kapaettu Satyamoorthy, Prabha Adhikari, Somyasree Rajesh
Publikováno v:
Molecular Genetics and Genomics. 291:193-204
Peroxisome proliferator-activated receptors (PPARγ), adiponectin (ADIPOQ) and fat mass and obesity-associated gene (FTO) have been reported as a key candidate genes for obesity, type 2 diabetes (T2D) susceptibility and insulin resistance, and we hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba4b076f8d643269b86cd243a680a48
https://doi.org/10.1007/s00438-015-1097-4
https://doi.org/10.1007/s00438-015-1097-4
Autor:
K. Geetha, Himanshu Gupta, Rayzel C. Fernandes, Sydney C. D’Souza, Kapaettu Satyamoorthy, Marriyah Hasan, Padmalatha S. Rai, Angela Brand, Prabha Adhikari, Manjunath H Hande
Publikováno v:
Molecular Genetics and Genomics, 290(3), 1155-1168. Springer Verlag
Antioxidant enzymes can contribute to disease susceptibility or determine response to therapy in individuals with malaria. Genetic variations due to polymorphisms in host genes encoding antioxidant enzymes such as glutathione S-transferases-theta, mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c4daa8021e939a2232684ac09d16c8
https://doi.org/10.1007/s00438-014-0984-4
https://doi.org/10.1007/s00438-014-0984-4
Autor:
Padmalatha S. Rai, Kapaettu Satyamoorthy, Sydney C. D’Souza, Umakanth Shashikiran, Prabha Adhikari, Shivashankara K. Nagri, P.R.R. Kalluri, Nagaraja M. Phani, Manik Vohra
Publikováno v:
Current molecular medicine. 17(8)
BACKGROUND:Several SNPs were identified through GWAS for their association with type 2 diabetes which has implications to pancreatic β-cell physiology. OBJECTIVE: We aimed to study the role of risk alleles of TCF7L2, KCNJ11, CDKN2A, CDKAL1, IGF2BP2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1266437d007296df545b45611a9258
https://pubmed.ncbi.nlm.nih.gov/29473503
https://pubmed.ncbi.nlm.nih.gov/29473503
Autor:
Kapaettu Satyamoorthy, Sreeja Kumari Dhanya, Manjunath H Hande, Abdul Vahab Saadi, Ramesh Chandra Sahoo, Himanshu Gupta, Arshia Angural, Sydney C. D’Souza, Devesh V. Oberoi, P. M. Gopinath, Sridevi Mony
Publikováno v:
Infection, Genetics and Evolution. 20:140-147
The essential route to blood parasitaemia in malaria, erythrocyte invasion is facilitated by activation of the G-protein coupled receptor signaling pathway mediated by the β2-adrenoreceptor as one of the proteins on the surface of red blood cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20550106dd93d7ae8e07b6b763752d41
https://doi.org/10.1016/j.meegid.2013.08.026
https://doi.org/10.1016/j.meegid.2013.08.026
Autor:
Prabha Adhikari, Kapaettu Satyamoorthy, Sydney C. D’Souza, Nagaraja M. Phani, Shivashankara K. Nagri, Padmalatha S. Rai
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157364 (2016)
PLoS ONE, Vol 11, Iss 6, p e0157364 (2016)
Aim: Several genetic variants for type 2 diabetes (T2D) have been identified through genome wide association studies (GWAS) from Caucasian population; however replication studies were not consistent across various ethnicities. Objective of the curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7fe7216c607990a21720304a27bb8e
http://europepmc.org/articles/PMC4911058
http://europepmc.org/articles/PMC4911058
Autor:
Himanshu Gupta, Sydney C. D’Souza, Thanvanthri Gururajan Vasudevan, Sima Chaudhari, Kapaettu Satyamoorthy, Shikha Srivastava, Shashikiran Umakanth, Manjunath H Hande
Publikováno v:
Acta tropica. 160
For the effective control of malaria, development of sensitive, accurate and rapid tool to diagnose and manage the disease is essential. In humans subjects, the severe form of malaria is caused by Plasmodium falciparum (Pf) and Plasmodium vivax (Pv)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae2060567625b1d9b6c817486adad53
https://pubmed.ncbi.nlm.nih.gov/27130076
https://pubmed.ncbi.nlm.nih.gov/27130076
Autor:
Sydney C. D’Souza, Kapaettu Satyamoorthy, Thanvanthri Gururajan Vasudevan, Shashikiran Umakanth, Manjunath H Hande, Susanta K. Ghosh, Abdul Vahab Saadi, Himanshu Gupta, Aditya Jain
Publikováno v:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 34
In the erythrocytes, malaria parasite entry and infection is mediated through complex membrane sorting and signaling processes. We investigated the effects of single-locus and multilocus interactions to test the hypothesis that the members of the GPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe25e4d09333a796806d217bdaa4046c
https://pubmed.ncbi.nlm.nih.gov/26066465
https://pubmed.ncbi.nlm.nih.gov/26066465