Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Sydney A. Labuzan"'
1
Akademický článek
Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease
Autor: Angela M. Crist, Kelly M. Hinkle, Xue Wang, Christina M. Moloney, Billie J. Matchett, Sydney A. Labuzan, Isabelle Frankenhauser, Nkem O. Azu, Amanda M. Liesinger, Elizabeth R. Lesser, Daniel J. Serie, Zachary S. Quicksall, Tulsi A. Patel, Troy P. Carnwath, Michael DeTure, Xiaojia Tang, Ronald C. Petersen, Ranjan Duara, Neill R. Graff-Radford, Mariet Allen, Minerva M. Carrasquillo, Hu Li, Owen A. Ross, Nilüfer Ertekin-Taner, Dennis W. Dickson, Yan W. Asmann, Rickey E. Carter, Melissa E. Murray
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Alzheimer’s disease (AD) is typically associated with hippocampal and cortical pathology, although hippocampal sparing and limbic predominant forms exist. The authors use transcriptomic analysis and neuropathology to identify genes associated with
Externí odkaz: https://doaj.org/article/4cd05f374d8e492f8281dd38dc11f183
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2
Akademický článek
Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection.
Autor: Isaac W Babcock, Lydia A Sibley, Sydney A Labuzan, Maureen N Cowan, Ish Sethi, Seblework Alemu, Abigail G Kelly, Michael A Kovacs, John R Lukens, Tajie H Harris
Publikováno v: PLoS Pathogens, Vol 20, Iss 10, p e1012006 (2024)
Inflammasome activation is a robust innate immune mechanism that promotes inflammatory responses through the release of alarmins and leaderless cytokines, including IL-1α, IL-1β, and IL-18. Various stimuli, including infectious agents and cellular
Externí odkaz: https://doaj.org/article/6d681f7f9119480db5ca6454d2a6eb03
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3
Akademický článek
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain
Autor: Michael A Kovacs, Maureen N Cowan, Isaac W Babcock, Lydia A Sibley, Katherine Still, Samantha J Batista, Sydney A Labuzan, Ish Sethi, Tajie H Harris
Publikováno v: eLife, Vol 11 (2022)
The discovery of meningeal lymphatic vessels that drain the CNS has prompted new insights into how immune responses develop in the brain. In this study, we examined how T cell responses against CNS-derived antigen develop in the context of infection.
Externí odkaz: https://doaj.org/article/994ef1d8384d4b9a86220589942e318d
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8
Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts
Autor: Peter T. Nelson, Carol Brayne, Margaret E. Flanagan, Erin L. Abner, Sonal Agrawal, Johannes Attems, Rudolph J. Castellani, Maria M. Corrada, Matthew D. Cykowski, Jing Di, Dennis W. Dickson, Brittany N. Dugger, John F. Ervin, Jane Fleming, Jonathan Graff-Radford, Lea T. Grinberg, Suvi R. K. Hokkanen, Sally Hunter, Alifiya Kapasi, Claudia H. Kawas, Hannah A. D. Keage, C. Dirk Keene, Mia Kero, David S. Knopman, Naomi Kouri, Gabor G. Kovacs, Sydney A. Labuzan, Eric B. Larson, Caitlin S. Latimer, Renata E. P. Leite, Billie J. Matchett, Fiona E. Matthews, Richard Merrick, Thomas J. Montine, Melissa E. Murray, Liisa Myllykangas, Sukriti Nag, Ruth S. Nelson, Janna H. Neltner, Aivi T. Nguyen, Ronald C. Petersen, Tuomo Polvikoski, R. Ross Reichard, Roberta D. Rodriguez, Claudia K. Suemoto, Shih-Hsiu J. Wang, Stephen B. Wharton, Lon White, Julie A. Schneider
Publikováno v: Acta Neuropathol
Refereed/Peer-reviewed Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer’s disease neuropathologic change (ADNC) are each associated with substantial cognitive impairment in aging populations. Howev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42264cbdfa96a5dbcbf8bf7cc96f45dd
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9
Meningeal lymphatic drainage promotes T cell responses againstToxoplasma gondiibut is dispensable for parasite control in the brain
Autor: Michael A. Kovacs, Maureen N. Cowan, Isaac W. Babcock, Lydia A. Sibley, Katherine Still, Samantha J. Batista, Sydney A. Labuzan, Ish Sethi, Tajie H. Harris
The discovery of meningeal lymphatic vessels that drain the central nervous system (CNS) has prompted new insights into how neuroinflammation develops. In this study, we examined how T cell responses against CNS-derived antigen develop in the context
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b246830831e62b4b9b3986c35632fb1
https://doi.org/10.1101/2022.06.02.494581
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10
Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis
Autor: Maureen N. Cowan, Michael A. Kovacs, Ish Sethi, Isaac W. Babcock, Katherine Still, Samantha J. Batista, Carleigh A. O’Brien, Jeremy A. Thompson, Lydia A. Sibley, Sydney A. Labuzan, Tajie H. Harris
Publikováno v: PLoS pathogens. 18(9)
Toxoplasma gondiiis a ubiquitous intracellular protozoan parasite that establishes a life-long chronic infection largely restricted to the central nervous system (CNS). Constant immune pressure, notably IFN-γ-STAT1 signaling, is required for prevent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae65fefa5a44643f4694b35285c9cdf4
https://pubmed.ncbi.nlm.nih.gov/36067217
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