Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Sydney A Labuzan"'
1
Akademický článek
Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection.
Autor: Isaac W Babcock, Lydia A Sibley, Sydney A Labuzan, Maureen N Cowan, Ish Sethi, Seblework Alemu, Abigail G Kelly, Michael A Kovacs, John R Lukens, Tajie H Harris
Publikováno v: PLoS Pathogens, Vol 20, Iss 10, p e1012006 (2024)
Inflammasome activation is a robust innate immune mechanism that promotes inflammatory responses through the release of alarmins and leaderless cytokines, including IL-1α, IL-1β, and IL-18. Various stimuli, including infectious agents and cellular
Externí odkaz: https://doaj.org/article/6d681f7f9119480db5ca6454d2a6eb03
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2
Akademický článek
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain
Autor: Michael A Kovacs, Maureen N Cowan, Isaac W Babcock, Lydia A Sibley, Katherine Still, Samantha J Batista, Sydney A Labuzan, Ish Sethi, Tajie H Harris
Publikováno v: eLife, Vol 11 (2022)
The discovery of meningeal lymphatic vessels that drain the CNS has prompted new insights into how immune responses develop in the brain. In this study, we examined how T cell responses against CNS-derived antigen develop in the context of infection.
Externí odkaz: https://doaj.org/article/994ef1d8384d4b9a86220589942e318d
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3
Akademický článek
Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis.
Autor: Maureen N Cowan, Michael A Kovacs, Ish Sethi, Isaac W Babcock, Katherine Still, Samantha J Batista, Carleigh A O'Brien, Jeremy A Thompson, Lydia A Sibley, Sydney A Labuzan, Tajie H Harris
Publikováno v: PLoS Pathogens, Vol 18, Iss 9, p e1010637 (2022)
Toxoplasma gondii is a ubiquitous intracellular protozoan parasite that establishes a life-long chronic infection largely restricted to the central nervous system (CNS). Constant immune pressure, notably IFN-γ-STAT1 signaling, is required for preven
Externí odkaz: https://doaj.org/article/5015eb02b10c4b9fb1a39faaf13c541f
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8
Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts
Autor: Peter T. Nelson, Carol Brayne, Margaret E. Flanagan, Erin L. Abner, Sonal Agrawal, Johannes Attems, Rudolph J. Castellani, Maria M. Corrada, Matthew D. Cykowski, Jing Di, Dennis W. Dickson, Brittany N. Dugger, John F. Ervin, Jane Fleming, Jonathan Graff-Radford, Lea T. Grinberg, Suvi R. K. Hokkanen, Sally Hunter, Alifiya Kapasi, Claudia H. Kawas, Hannah A. D. Keage, C. Dirk Keene, Mia Kero, David S. Knopman, Naomi Kouri, Gabor G. Kovacs, Sydney A. Labuzan, Eric B. Larson, Caitlin S. Latimer, Renata E. P. Leite, Billie J. Matchett, Fiona E. Matthews, Richard Merrick, Thomas J. Montine, Melissa E. Murray, Liisa Myllykangas, Sukriti Nag, Ruth S. Nelson, Janna H. Neltner, Aivi T. Nguyen, Ronald C. Petersen, Tuomo Polvikoski, R. Ross Reichard, Roberta D. Rodriguez, Claudia K. Suemoto, Shih-Hsiu J. Wang, Stephen B. Wharton, Lon White, Julie A. Schneider
Publikováno v: Acta Neuropathol
Refereed/Peer-reviewed Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer’s disease neuropathologic change (ADNC) are each associated with substantial cognitive impairment in aging populations. Howev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42264cbdfa96a5dbcbf8bf7cc96f45dd
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9
Meningeal lymphatic drainage promotes T cell responses againstToxoplasma gondiibut is dispensable for parasite control in the brain
Autor: Michael A. Kovacs, Maureen N. Cowan, Isaac W. Babcock, Lydia A. Sibley, Katherine Still, Samantha J. Batista, Sydney A. Labuzan, Ish Sethi, Tajie H. Harris
The discovery of meningeal lymphatic vessels that drain the central nervous system (CNS) has prompted new insights into how neuroinflammation develops. In this study, we examined how T cell responses against CNS-derived antigen develop in the context
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b246830831e62b4b9b3986c35632fb1
https://doi.org/10.1101/2022.06.02.494581
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10
Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain
Autor: Christina M. Moloney, Sydney A. Labuzan, Julia E. Crook, Habeeba Siddiqui, Monica Castanedes‐Casey, Christian Lachner, Ronald C. Petersen, Ranjan Duara, Neill R. Graff‐Radford, Dennis W. Dickson, Michelle M. Mielke, Melissa E. Murray
Publikováno v: Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES.
Alzheimer's disease (AD) biomarkers are increasingly more reliable in predicting neuropathology. To facilitate interpretation of phosphorylated tau sites as an early fluid biomarker, we sought to characterize which neurofibrillary tangle maturity lev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc0e75fd1e7104252f40cb3d116409e
https://pubmed.ncbi.nlm.nih.gov/35920592
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