Interpretation and visualization of non-linear data fusion in kernel space: study on metabolomic characterization of progression of multiple sclerosis.

Autor: Agnieszka Smolinska, Lionel Blanchet, Leon Coulier, Kirsten A M Ampt, Theo Luider, Rogier Q Hintzen, Sybren S Wijmenga, Lutgarde M C Buydens

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38163 (2012)

BACKGROUND: In the last decade data fusion has become widespread in the field of metabolomics. Linear data fusion is performed most commonly. However, many data display non-linear parameter dependences. The linear methods are bound to fail in such si

Externí odkaz: https://doaj.org/article/a505c42347ac4424ba9c1f069ddc3bc2

Determination of long-range scalar H-1-H-1 coupling constants responsible for polarization transfer in SABRE

Autor: Bram J. A. van Weerdenburg, Martin C. Feiters, Nan Eshuis, Sybren S. Wijmenga, Floris P. J. T. Rutjes, Ruud L. E. G. Aspers, Marco Tessari

Publikováno v: Journal of Magnetic Resonance, 265, 59-66
Journal of Magnetic Resonance, 265, pp. 59-66

SABRE (Signal Amplification By Reversible Exchange) nuclear spin hyperpolarization method can provide strongly enhanced NMR signals as a result of the reversible association of small molecules with para-hydrogen (p-H2) at an iridium metal complex. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90d5d5dc73be91938a69c47a83bb211
https://doi.org/10.1016/j.jmr.2016.01.012

Quantitative Trace Analysis of Complex Mixtures Using SABRE Hyperpolarization

Autor: Nan Eshuis, Marco Tessari, Martin C. Feiters, Bram J. A. van Weerdenburg, Sybren S. Wijmenga, Floris P. J. T. Rutjes

Publikováno v: Angewandte Chemie. International Edition, 54, 5, pp. 1481-1484
Angewandte Chemie. International Edition, 54, 1481-1484

Signal amplification by reversible exchange (SABRE) is an emerging nuclear spin hyperpolarization technique that strongly enhances NMR signals of small molecules in solution. However, such signal enhancements have never been exploited for concentrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8649fb189f7fc3fe2af81a0cdecbb9
https://doi.org/10.1002/ange.201409795

Magnetic susceptibility to measure total protein concentration from NMR metabolite spectra: Demonstration on blood plasma

Autor: Paul J. Michiels, Sybren S. Wijmenga, Frederic C. Girard, Marc Jupin

Publikováno v: Magnetic Resonance in Medicine. 73:459-468

Purpose Accurate metabolite and protein quantification in blood plasma and other body fluids from one single NMR measurement, allowing for improved quantitative metabolic profiling and better assessment of metabolite-protein interactions. Theory and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58d4b3fa7f903b49eb739b2ab76661b3
https://doi.org/10.1002/mrm.25178

Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

Autor: Sybren S. Wijmenga, Ruud L. E. G. Aspers, Jenny I. Halff, René van Elk, Reka A. Otvos, Andreas W. Ehlers, Richard J. Lewis, Ferry Heus, Wilfried M. A. Niessen, Sébastien Dutertre, Jeroen Kool, August B. Smit

Publikováno v: Biology
Biology, MDPI 2014, 3 (1), pp.139-156. ⟨10.3390/biology3010139⟩
Biology, 3, 1, pp. 139-156
Heus, F A H, Otvos, R A, Aspers, R L E G, van Elk, R, Halff, J I, Ehlers, A W, Duterte, S, Lewis, R J, Wijmenga, S, Smit, A B, Niessen, W M A & Kool, J 2014, ' Miniaturized bioactivity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail ', Biology, vol. 3, pp. 139-156 . https://doi.org/10.3390/biology3010139
Biology, 3, 139-156. Multidisciplinary Digital Publishing Institute (MDPI)
Biology; Volume 3; Issue 1; Pages: 139-156
Biology, 3, 139-156
Biology, Vol 3, Iss 1, Pp 139-156 (2014)

A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca403a753e3c96642a854645b6c89308
https://doi.org/10.3390/biology3010139