Výsledky vyhledávání - "Sybille Somogyi"

Akademický článek

Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors

Autor: Karolin Meixenberger, Kaveh Pouran Yousef, Maureen Rebecca Smith, Sybille Somogyi, Stefan Fiedler, Barbara Bartmeyer, Osamah Hamouda, Norbert Bannert, Max von Kleist, Claudia Kücherer

Publikováno v: Virology Journal, Vol 14, Iss 1, Pp 1-13 (2017)

Abstract Background Detailed knowledge of the evolutionary potential of polymorphic sites in a viral protein is important for understanding the development of drug resistance in the presence of an inhibitor. We therefore set out to analyse the molecu

Externí odkaz: https://doaj.org/article/d7848cda650745b98b6753332569e020

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Akademický článek

Improved testing of recent HIV-1 infections with the BioRad avidity assay compared to the limiting antigen avidity assay and BED Capture enzyme immunoassay: evaluation using reference sample panels from the German Seroconverter Cohort.

Autor: Andrea Hauser, Claudia Santos-Hoevener, Karolin Meixenberger, Ruth Zimmermann, Sybille Somogyi, Stefan Fiedler, Alexandra Hofmann, Barbara Bartmeyer, Klaus Jansen, Osamah Hamouda, Norbert Bannert, Claudia Kuecherer

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98038 (2014)

BACKGROUND: The variety and limitations of current laboratory methods for estimating HIV-incidence has driven attempts to improve and standardize the performance of serological 'Tests for Recent HIV-Infections' (TRI). Primary and follow-up HIV-1 posi

Externí odkaz: https://doaj.org/article/3d156709cf9c4e7797224ed4705892ea

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Akademický článek

First line treatment response in patients with transmitted HIV drug resistance and well defined time point of HIV infection: updated results from the German HIV-1 seroconverter study.

Autor: Fabia Zu Knyphausen, Ramona Scheufele, Claudia Kücherer, Klaus Jansen, Sybille Somogyi, Stephan Dupke, Heiko Jessen, Dirk Schürmann, Osamah Hamouda, Karolin Meixenberger, Barbara Bartmeyer

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e95956 (2014)

BACKGROUND: Transmission of drug-resistant HIV-1 (TDR) can impair the virologic response to antiretroviral combination therapy. Aim of the study was to assess the impact of TDR on treatment success of resistance test-guided first-line therapy in the

Externí odkaz: https://doaj.org/article/63729102d56d4748b883c10d1aa4e39b

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Akademický článek

Prevalence of transmitted drug resistance and impact of transmitted resistance on treatment success in the German HIV-1 Seroconverter Cohort.

Autor: Barbara Bartmeyer, Claudia Kuecherer, Claudia Houareau, Johanna Werning, Kathrin Keeren, Sybille Somogyi, Christian Kollan, Heiko Jessen, Stephan Dupke, Osamah Hamouda, German HIV-1 Seroconverter Study Group

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e12718 (2010)

BackgroundThe aim of this study is to analyse the prevalence of transmitted drug resistance, TDR, and the impact of TDR on treatment success in the German HIV-1 Seroconverter Cohort.MethodsGenotypic resistance analysis was performed in treatment-naï

Externí odkaz: https://doaj.org/article/66da739f785a4479aecd1e5b093c2f08

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Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors

Autor: Norbert Bannert, Stefan Fiedler, Sybille Somogyi, Karolin Meixenberger, Kaveh Pouran Yousef, Osamah Hamouda, Maureen R. Smith, Barbara Bartmeyer, Claudia Kücherer, Max von Kleist

Publikováno v: Virology Journal, Vol 14, Iss 1, Pp 1-13 (2017)
Virology Journal

Background Detailed knowledge of the evolutionary potential of polymorphic sites in a viral protein is important for understanding the development of drug resistance in the presence of an inhibitor. We therefore set out to analyse the molecular evolu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a703dd0c1bf3650899dd3be6114501a
http://link.springer.com/article/10.1186/s12985-017-0887-1

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Inferring HIV-1 Transmission Dynamics in Germany From Recently Transmitted Viruses

Autor: Daniel Schmidt, Barbara Gunsenheimer-Bartmeyer, Maureen R. Smith, Karolin Meixenberger, Max von Kleist, Claudia Kücherer, Sybille Somogyi, Osamah Hamouda, Silvana Gromöller, Kaveh Pouran Yousef

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 73:356-363

BACKGROUND Although HIV continues to spread globally, novel intervention strategies such as treatment as prevention (TasP) may bring the epidemic to a halt. However, their effective implementation requires a profound understanding of the underlying t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700f312aee557e3d908f45e661cbdb12
https://doi.org/10.1097/qai.0000000000001122

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Minor Drug-Resistant HIV Type-1 Variants in Breast Milk and Plasma of HIV Type-1-Infected Ugandan Women after Nevirapine Single-Dose Prophylaxis

Autor: Andrea Kunz, Andrea Hauser, Gundel Harms, Claudia Kuecherer, Daniel Pilger, Kizito Mugenyi, Rose Kabasinguzi, Sybille Somogyi

Publikováno v: Antiviral Therapy. 16:109-113

Background Nevirapine single-dose (NVP-SD) reduces mother-to-child transmission of HIV type-1 (HIV-1), but frequently induces resistance mutations in the HIV-1 genome. Little is known about drug-resistant HIV-1 variants in the breast milk of women wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fda2638f656c3af5dfb51cc745c3da
https://doi.org/10.3851/imp1698

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Impact of transmission of drug-resistant HIV on the course of infection and the treatment success. Data from the German HIV-1 Seroconverter Study

Autor: Heiko Jessen, Osamah Hamouda, B Bieniek, Claudia Kücherer, S Dupke, J Werning, Gabriele Poggensee, Sybille Somogyi

Publikováno v: HIV Medicine. 8:511-519

Data on the clinical course of infection in patients with transmitted drug-resistant HIV before and after initiation of treatment are scarce.Genotypic resistance was analysed in 504 therapy-naïve individuals with a known date of infection. Resistanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4256ec3170b05d135f2799a610ec07f
https://doi.org/10.1111/j.1468-1293.2007.00504.x

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Assessment of ambiguous base calls in HIV-1 pol population sequences as a biomarker for identification of recent infections in HIV-1 incidence studies

Autor: Klaus Jansen, Kaveh Pouran Yousef, Stephen Norley, Karolin Meixenberger, Stefan Fiedler, Norbert Bannert, Claudia Kücherer, Sybille Somogyi, Andrea Hauser, M. von Kleist, Barbara Bartmeyer, Osamah Hamouda

Publikováno v: Journal of clinical microbiology. 52(8)

An increase in the proportion of ambiguous base calls in HIV-1 pol population sequences during the course of infection has been demonstrated in different study populations, and sequence ambiguity thresholds to classify infections as recent or nonrece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bf5afdfb44491fab0bad78cdcdcc9b
https://pubmed.ncbi.nlm.nih.gov/24920768

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Autor: Stefan Fiedler, Claudia Kuecherer, Klaus Jansen, Osamah Hamouda, Alexandra Hofmann, Claudia Santos-Hoevener, Sybille Somogyi, Andrea Hauser, Norbert Bannert, Barbara Bartmeyer, Karolin Meixenberger, Ruth Zimmermann

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e98038 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab9e7a17f4b6c6cccf7cb4c829c843c
https://pubmed.ncbi.nlm.nih.gov/24892795

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