Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sybille L. Sauter"'
Autor:
Jason Heth, Deborah A. Cory-Slechta, Paul M. McCray, Beverly L. Davidson, Howard J. Federoff, Andrew I. Brooks, Julie C. Johnston, Colleen S. Stein, Sybille L. Sauter, Stephanie M. Hughes
Publikováno v:
Proceedings of the National Academy of Sciences. 99:6216-6221
Gene transfer vectors based on lentiviruses can transduce terminally differentiated cells in the brain; however, their ability to reverse established behavioral deficits in animal models of neurodegeneration has not previously been tested. When recom
Publikováno v:
Molecular Therapy. 5:16-24
Neural progenitor cells may provide for cell replacement or gene delivery vehicles in neurodegen-erative disease therapies. The expression of therapeutic proteins by neural progenitors would be enhanced by viral-mediated gene transfer, but the effect
Publikováno v:
The Journal of Gene Medicine. 4:463-469
Background Transduction of the murine retinal pigmented epithelium (RPE) with adenovirus vectors requires technically difficult and invasive subretinal injections. This study tested the hypothesis that recombinant vectors based on feline immunodefici
Autor:
Jiahua Qian, Yubin Kang, Todd A. Derksen, Beverly L. Davidson, Inês Martins, Patrick D. Staber, Sybille L. Sauter, Kay Townsend, Paul B. McCray, Colleen S. Stein
Publikováno v:
Molecular Therapy. 3:850-856
Gene therapy holds great promise for the treatment of a variety of inherited diseases, including hemophilia A and mucopolysaccharidosis type VII (MPS VII). In both these disorders, subnormal levels of replacement protein have therapeutic effects. Thu
Autor:
Sybille L. Sauter, Mehdi Gasmi
Publikováno v:
Somatic Cell and Molecular Genetics. 26:99-129
Why is feline immunodeficiency virus (FIV) such an appealing candidate for gene therapy vector development? Phylogenetic analysis suggests FIV is only distantly related to the primate lentiviruses, and despite repeated exposure, neither seroconversio
VSV-G Pseudotyped Lentiviral Vector Particles Produced in Human Cells Are Inactivated by Human Serum
Autor:
Philip Lee Sheridan, Nicholas J. DePolo, Sybille L. Sauter, Kay Townsend, Joyce D. Reed, Thomas W. Dubensky, Douglas J. Jolly
Publikováno v:
Molecular Therapy. 2:218-222
Lentiviral vectors transduce dividing and postmitotic cells and thus are being developed toward therapies for many diseases affecting diverse tissues. One essential requirement for efficacy will be that vector particles are resistant to inactivation
Autor:
James E. McCormack, Nancy Sajjadi, Thomas W. Dubensky, James G. Respess, Joanne O'Dea, Trung K. Phuong, Carlos E. Ibanez, Judith Greengard, Philip Lee Sheridan, Margaret Dow Moore, Daniel J. de la Vega, Sybille L. Sauter, Kay Townsend, Kathy Nguyen, David A. Driver, Douglas J. Jolly, Andrea Lynn, Nicholas J. DePolo, Mordechai Bodner, Stephen M. W. Chang
Publikováno v:
Molecular Therapy. 2(3):262-275
For many applications, human clinical therapies using retroviral vectors still require many technological improvements in key areas of vector design and production. These improvements include higher unprocessed manufacturing titers, complement-resist
Autor:
Douglas J. Jolly, John A. Chiorini, Sybille L. Sauter, Stephanie M. Hughes, Thomas W. Dubensky, Joseph Martin Alisky, Beverly L. Davidson, Patrick D. Staber
Publikováno v:
NeuroReport. 11:2669-2673
Our data demonstrate that vectors derived from recombinant feline immunodeficiency virus (rFIV) and adeno-associated virus type 5 (rAAV5) transduce cerebellar cells following direct injection into the cerebellar lobules of mice. Both recombinant viru
Autor:
Carlos E. Ibanez, Gerhard Bauer, Donald B. Kohn, Doug J. Jolly, Sybille L. Sauter, Penelope Valdez, C. Robert Rice
Publikováno v:
Europe PubMed Central
ResearcherID
ResearcherID
Using retroviral supernatants derived from the amphotropic murine packaging cell line PA317 and the amphotropic canine packaging cell line (DA), cord blood and mobilized peripheral blood CD34+ cells were transduced with the vector LN (neomycin resist