Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Syaulan Yang"'
Autor:
Dean Messing, Win Naing, Joseph P. Portanova, Tina Kim, Alan G. Benson, Shaun R. Selness, Daniel L. Flynn, Joseph B. Monahan, Richard Lindmark, Huey S. Shieh, John K. Walker, Syaulan Yang, Ravi Kurambail, Rajesh V. Devraj, Michael Hepperle, Dice Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2634-2638
Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38alpha kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position lea
Autor:
Cheng-Chung Lee, Tzu-Ping Ko, Shu-Jen Chen, Shih Cheng Chang, Min-Feng Hsu, Chih-Jung Kuo, Hua-Chien Chen, Ming Chu Hsu, Yao Chen Tsui, Andrew H.-J. Wang, Shin-Ru Shih, Syaulan Yang, Po-Huang Liang
Publikováno v:
Journal of Biological Chemistry
Human coxsackievirus (CV) belongs to the picornavirus family, which consists of over 200 medically relevant viruses. In picornavirus, a chymotrypsin-like protease (3C(pro)) is required for viral replication by processing the polyproteins, and thus it
Autor:
Chun Wei Kuo, Yu Fan Liu, Hui Lin Shr, Hua-Chien Chen, Ming Chu Hsu, Shu-Jen Chen, Cheng Yuan Liu, Hsin Hui Hung, Jen Chi Hsu, Teng Yuan Chang, Syaulan Yang, Shao Ying Liao, Ling Yin Chang, Li Wen Chang, Yu An Huang, Andrew H.-J. Wang, Chi Shen Wu, Min-Feng Hsu, Jen Dar Wu, Clarence J. Peters, Wen Chang Chen, Chien Te K. Tseng
Publikováno v:
Journal of Medicinal Chemistry. 49:4971-4980
A potent SARS coronavirus (CoV) 3CL protease inhibitor (TG-0205221, Ki = 53 nM) has been developed. TG-0205221 showed remarkable activity against SARS CoV and human coronavirus (HCoV) 229E replications by reducing the viral titer by 4.7 log (at 5 mic
Publikováno v:
Inorganic Chemistry. 41:1778-1781
The first integrally oxidized metal-free phthalocyanine compounds have been synthesized by chemical oxidation. Phthalocyanine (H2(pc), pc = phthalocyaninato) was oxidized with IBr to afford the compounds [H2(pc)][IBr2] (1) and [H2(pc)]2[IBr2]BrAC10H7
Publikováno v:
ChemInform. 30
Autor:
John I, Trujillo, Marvin J, Meyers, David R, Anderson, Shridhar, Hegde, Matthew W, Mahoney, William F, Vernier, Ingrid P, Buchler, Kun K, Wu, Syaulan, Yang, Syaluan, Yang, Susan J, Hartmann, David B, Reitz
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(16)
A structure-activity relationship study was conducted on a series of tetrahydro-beta-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protei
Publikováno v:
Inorganic chemistry. 41(7)
The first integrally oxidized metal-free phthalocyanine compounds have been synthesized by chemical oxidation. Phthalocyanine (H(2)(pc), pc = phthalocyaninato) was oxidized with IBr to afford the compounds [H(2)(pc)][IBr(2)] (1) and [H(2)(pc)](2)[IBr
Autor:
Hartmann Susan J, David B. Reitz, Kun K. Wu, John I. Trujillo, William F. Vernier, David R. Anderson, Marvin J. Meyers, Matthew W. Mahoney, Shridhar Hegde, Syaulan Yang, Ingrid P. Buchler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2365
Autor:
Hui-Lin Shr, Tzu-Ping Ko, Chih-Jung Kuo, Ming-Chu Hsu, Syaulan Yang, Shu-Jen Chen, Kai-Ti Chang, Yao-Chen Teui, Andrew H.-J. Wang, Po-Huang Liang, Min-Feng Hsu
Publikováno v:
Seibutsu Butsuri. 46:S443
Autor:
Wade Jarrell, Theodore F. Baumann, Syaulan Yang, Brian M. Hoffman, L. Scott Beall, David J. Williams, Anthony G. M. Barrett, Andrew J. P. White, David M. Eichhorn
Publikováno v:
J. Chem. Soc., Chem. Commun.. :1703-1704
Reaction of octakis(dimethylamino) porphyrazine 1 with [60]fullerene gives a crystalline 2:1 charge-transfer (CT) complex as a three-dimensional network of chains; in contrast, reaction of 1 with tetracyanoquinodimethane (TCNQ) gives a crystalline 1: