Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Syandan, Chakraborty"'
Autor:
Syandan Chakraborty, HaYeun Ji, Ami M. Kabadi, Charles A. Gersbach, Nicolas Christoforou, Kam W. Leong
Publikováno v:
Stem Cell Reports, Vol 3, Iss 6, Pp 940-947 (2014)
Gene activation by the CRISPR/Cas9 system has the potential to enable new approaches to science and medicine, but the technology must be enhanced to robustly control cell behavior. We show that the fusion of two transactivation domains to Cas9 dramat
Externí odkaz:
https://doaj.org/article/930026d722764cd4846de3bb46a8f911
Autor:
Nicolas Christoforou, Brian Liau, Syandan Chakraborty, Malathi Chellapan, Nenad Bursac, Kam W Leong
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65963 (2013)
The mammalian heart has little capacity to regenerate, and following injury the myocardium is replaced by non-contractile scar tissue. Consequently, increased wall stress and workload on the remaining myocardium leads to chamber dilation, dysfunction
Externí odkaz:
https://doaj.org/article/704e201be9124dbfb98e823f9e59501e
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64342 (2013)
Viral vectors remain the most efficient and popular in deriving induced pluripotent stem cells (iPSCs). For translation, it is important to silence or remove the reprogramming factors after induction of pluripotency. In this study, we design an excis
Externí odkaz:
https://doaj.org/article/fa6a782ca870493b81d10b48967a0b15
Autor:
Cassie Messenger, Laurie J. Gordon, Simon C. C. Lucas, Aaron T. Cheng, Kelly M Gatfield, John P. Evans, Emma J. Jones, Mahnoor Mahmood, Charles S. Lay, Charlotte E. Carver, Douglas Sammon, Antonia J. Lewis, Alexander N Phillipou, Syandan Chakraborty, Luke A Greenhough, Peter D. Craggs, David J Brierley
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(2)
Malfunctions in the basic epigenetic mechanisms such as histone modifications, DNA methylation, and chromatin remodeling are implicated in a number of cancers and immunological and neurodegenerative conditions. Within GlaxoSmithKline (GSK) we have ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc63556b946b71c8a1576c30413bb503
https://pubmed.ncbi.nlm.nih.gov/31875412
https://pubmed.ncbi.nlm.nih.gov/31875412
Autor:
Xin Xu, Jianjun Cheng, Kam W. Leong, Du Cheng, Jing Gong, Hong-Xia Wang, Dantong Huang, Ziyuan Song, Yeh-Hsing Lao, Ji Sun Park, Syandan Chakraborty, Mingqiang Li, Lichen Yin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Delivery remains a significant challenge for robust implementation of CRISPR/Cas9. We report an efficient CRISPR/Cas9 delivery system comprising PEGylated nanoparticles based on the α-helical polypeptide PPABLG. Assisted by the high mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df67506c97040d5ee62f18416507d00
https://doi.org/10.1073/pnas.1712963115
https://doi.org/10.1073/pnas.1712963115
Autor:
Gordana Vunjak-Novakovic, Damian J. Williams, Syandan Chakraborty, Kam W. Leong, Surapon N. Charoensook
Publikováno v:
Integrative Biology. 9:956-967
In vitro models of the neuromuscular junction (NMJ) are emerging as a valuable tool to study synaptogenesis, synaptic maintenance, and pathogenesis of neurodegenerative diseases. Many models have previously been developed using a variety of cell sour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddc6637f7d2567f4f3eb1cd8baf318a
https://doi.org/10.1039/c7ib00144d
https://doi.org/10.1039/c7ib00144d
Autor:
Phillipou, Alexander N., Lay, Charles S., Carver, Charlotte E., Messenger, Cassie, Evans, John P., Lewis, Antonia J., Gordon, Laurie J., Mahnoor Mahmood, Greenhough, Luke A., Sammon, Douglas, Cheng, Aaron T., Syandan Chakraborty, Jones, Emma J., Lucas, Simon C. C., Gatfield, Kelly M., Brierley, David J., Craggs, Peter D.
Supplemental material, 2019_SLAS_DISCO_TEG_GSK_MS_FINAL_Version_191113_Supporting for Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions by Alexander N. Phillipou, Charles S. Lay, Charlotte E. Carver, Cassie Messen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632238ccec2368faaa7f495dd3f28c4a
Autor:
Mohamed M. Ibrahim, Elizabeth R. Lorden, Ellen Hammett, Kyle J. Miller, Howard Levinson, M. Angelica Selim, Carlos Quiles-Torres, Latif Bashirov, Kam W. Leong, Syandan Chakraborty
Publikováno v:
Acta Biomaterialia. 32:100-109
Burn injuries in the United States account for over one million hospital admissions per year, with treatment estimated at four billion dollars. Of severe burn patients, 30–90% will develop hypertrophic scars (HSc). In this study, we evaluate the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32bb28d7091ec430801e2d7124af0f5
https://doi.org/10.1016/j.actbio.2015.12.025
https://doi.org/10.1016/j.actbio.2015.12.025
Autor:
Yeh-Hsing, Lao, Mingqiang, Li, Madeleine A, Gao, Dan, Shao, Chun-Wei, Chi, Dantong, Huang, Syandan, Chakraborty, Tzu-Chieh, Ho, Weiqian, Jiang, Hong-Xia, Wang, Sihong, Wang, Kam W, Leong
Publikováno v:
Advanced Science
CRISPR/Cas9 technology enables targeted gene editing; yet, the efficiency and specificity remain unsatisfactory, particularly for the nonvirally delivered, plasmid‐based CRISPR/Cas9 system. To tackle this, a self‐assembled micelle is developed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d7abba2221eeb3d30d0880283a85c4b
https://pubmed.ncbi.nlm.nih.gov/30027026
https://pubmed.ncbi.nlm.nih.gov/30027026
Autor:
Robert D. Kirkton, Russell C. Addis, Nicolas Christoforou, Andrew F. Adler, Syandan Chakraborty, Kam W. Leong
Publikováno v:
Scientific Reports
Transdifferentiation has been described as a novel method for converting human fibroblasts into induced cardiomyocyte-like cells. Such an approach can produce differentiated cells to study physiology or pathophysiology, examine drug interactions or t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6e58dbc3bf8bb93e67dd24817fd4e9
https://doi.org/10.1038/srep40285
https://doi.org/10.1038/srep40285