Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Syam Prakash Somasekharan"'
Autor:
Neetu Saxena, Eliana Beraldi, Ladan Fazli, Syam Prakash Somasekharan, Hans Adomat, Fan Zhang, Chidi Molokwu, Anna Gleave, Lucia Nappi, Kimberly Nguyen, Pavn Brar, Nicholas Nikesitch, Yuzhuo Wang, Colin Collins, Poul H Sorensen, Martin Gleave
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021)
Abstract Treatment‐induced adaptive pathways converge to support androgen receptor (AR) reactivation and emergence of castration‐resistant prostate cancer (PCa) after AR pathway inhibition (ARPI). We set out to explore poorly defined acute adapti
Externí odkaz:
https://doaj.org/article/5793efb5d6f840efadd0ab2793d10dfc
Autor:
Syam Prakash Somasekharan, Neetu Saxena, Fan Zhang, Eliana Beraldi, Jia Ni Huang, Christina Gentle, Ladan Fazli, Marisa Thi, Poul H Sorensen, Martin Gleave
Publikováno v:
Nucleic Acids Research
We report a new mechanism of androgen receptor (AR) mRNA regulation and cytoprotection in response to AR pathway inhibition (ARPI) stress in prostate cancer (PCA). AR mRNA translation is coordinately regulated by RNA binding proteins, YTHDF3 and G3BP
Publikováno v:
Febs Letters
The current work investigated SARS‐CoV‐2 Nucleocapsid (NCAP or N protein) interactors in A549 human lung cancer cells using a SILAC‐based mass spectrometry approach. NCAP interactors included proteins of the stress granule (SG) machinery and im
Autor:
I-Chih Kuo, Neetu Saxena, Martin E. Gleave, Leonard J. Foster, Fan Zhang, Syam Prakash Somasekharan, Robert H. Bell, Nikolay Stoynov, Hans Adomat, Jia Ni Huang, Caitlin Low, Poul H Sorensen
Publikováno v:
Nucleic Acids Research
Cells limit energy-consuming mRNA translation during stress to maintain metabolic homeostasis. Sequestration of mRNAs by RNA binding proteins (RBPs) into RNA granules reduces their translation, but it remains unclear whether RBPs also function in par
Autor:
Martin E. Gleave, Chidi Molokwu, Colin Collins, Poul H. Sorensen, Pavn Brar, Anna Gleave, Fan Zhang, Neetu Saxena, Kimberly Nguyen, Lucia Nappi, Yuzhuo Wang, Hans Adomat, Syam Prakash Somasekharan, Nicholas Nikesitch, Ladan Fazli, Eliana Beraldi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine
Treatment‐induced adaptive pathways converge to support androgen receptor (AR) reactivation and emergence of castration‐resistant prostate cancer (PCa) after AR pathway inhibition (ARPI). We set out to explore poorly defined acute adaptive respon
Autor:
Leszek Kotula, Lauren Leachman, A. Kretschmer, Teresa Huang, Fan Zhang, Martin E. Gleave, Syam Prakash Somasekharan, Ivan Asmaro, Poul H. Sorensen, Brian C.M. Li, Anna Gleave, Charan Tse
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Tunneling nanotubes (TNTs) are actin-based membranous structures bridging distant cells for intercellular communication. We define roles for TNTs in stress adaptation and treatment resistance in prostate cancer (PCa). Androgen receptor (AR) blockade
Publikováno v:
Journal of Proteomics. 247:104334
Withaferin A (WA) is a steroidal lactone extracted from Withania somnifera, commonly known as Ashwagandha. WA has several therapeutic benefits. The current study aims to identify proteins that are potentially regulated by WA in prostate cancer (PCA)
Autor:
Xue Qi Wang, Fan Zhang, Syam Prakash Somasekharan, Jordan Cran, Olivier Delattre, Melvin Pan, Christopher S. Hughes, Hongwei Cheng, Yemin Wang, Poul H. Sorensen, David G. Huntsman, Anna Mandinova, Amal El-Naggar, Hai-Feng Zhang, Shane Colborne, Yuzhuo Wang, Didier Surdez, Bo Rafn, Gian Luca Negri, Martin E. Gleave, Nancy Kedersha, Gregg B. Morin, Alberto Delaidelli
Publikováno v:
EMBO Reports
Outcomes for metastatic Ewing sarcoma and osteosarcoma are dismal and have not changed for decades. Oxidative stress attenuates melanoma metastasis, and melanoma cells must reduce oxidative stress to metastasize. We explored this in sarcomas by scree
Autor:
Ravish Rashpa, Vikram Govind Panse, Julien Cornut, Syam Prakash Somasekharan, Martine A. Collart, Cohue Peña, Sarah H. Carl, Jawad Iqbal, Olesya O. Panasenko, Marina Zagatti, Marion Longis, Zoltan Villanyi, Fedor Bezrukov
Publikováno v:
Nature Structural & Molecular Biology, Vol. 26, No 2 (2019) pp. 110-120
Panasenko, O, Somasekharan, S P, Villanyi, Z, Zagatti, M, Bezrukov, F, Rashpa, R, Cornut, J, Longis, M, Carl, S, Peña, C, Panse, V & Collart, M 2019, ' Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes ', Nature Structural and Molecular Biology . https://doi.org/10.1038/s41594-018-0179-5
Panasenko, O, Somasekharan, S P, Villanyi, Z, Zagatti, M, Bezrukov, F, Rashpa, R, Cornut, J, Longis, M, Carl, S, Peña, C, Panse, V & Collart, M 2019, ' Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes ', Nature Structural and Molecular Biology . https://doi.org/10.1038/s41594-018-0179-5
The assembly of large multimeric complexes in the crowded cytoplasm is challenging. Here we reveal a mechanism that ensures accurate production of the yeast proteasome, involving ribosome pausing and co-translational assembly of Rpt1 and Rpt2. Intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120f62001544054a6aae7dd8353d8413
https://archive-ouverte.unige.ch/unige:115220
https://archive-ouverte.unige.ch/unige:115220
Autor:
Forum Bhanshali, Stefan Taubert, Ian R. A. Mackenzie, Poul H. Sorensen, Don Moerman, Michael R. Hayden, Gian Luca Negri, Milène Vandal, Alberto Delaidelli, Frédéric Calon, Asad Jan, Syam Prakash Somasekharan, Brandon Jansonius
Publikováno v:
Acta Neuropathologica. 133:101-119
Soluble oligomers of amyloid-β (Aβ) impair synaptic plasticity, perturb neuronal energy homeostasis, and are implicated in Alzheimer's disease (AD) pathogenesis. Therefore, significant efforts in AD drug discovery research aim to prevent the format