Preparation and antimicrobial assessment of 2-thioether-linked quinolonyl-carbapenems

Autor: Zoutendam Ph, Switzer Ag, T. P. Demuth, Tracy L. Twinem, Imbus R, Paula M. Koenigs, Paule Sm, Coleman Mc, Kraft Wg, Hershberger Pm, F. J. Rourke, Davis Bw, Devries Ca, Yelm Ke, Richard Siehnel

Publikováno v: The Journal of antibiotics. 51(9)

This reports the synthesis and in vitro antimicrobial properties of a series of 2-thioether-linked quinolonyl-carbapenems. Although the title compounds exhibited broad spectrum activity, the MICs were generally higher than those observed for selected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9249505b74377ccbb702e5778d6dcc4
https://pubmed.ncbi.nlm.nih.gov/9820237

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Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.

Autor: Tian X; Procter & Gamble Pharmaceuticals, Global Business & New Technology Development, Mason, Ohio 45040, USA. xinrong.2.tian@gsk.com, Switzer AG, Derose SA, Mishra RK, Solinsky MG, Mumin RN, Ebetino FH, Jayasinghe LR, Webster ME, Colson AO, Crossdoersen D, Pinney BB, Farmer JA, Dowty ME, Obringer CM, Cruze CA, Burklow ML, Suchanek PM, Dong L, Dirr MK, Sheldon RJ, Wos JA

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2008 Oct 09; Vol. 51 (19), pp. 6055-66. Date of Electronic Publication: 2008 Sep 05.

Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic approach.

Autor: Tian X; Procter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, Ohio 45040, USA. tian.x@pg.com, Field TB, Switzer AG, Mazur AW, Ebetino FH, Wos JA, Berberich SM, Jayasinghe LR, Obringer CM, Dowty ME, Pinney BB, Farmer JA, Crossdoersen D, Sheldon RJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2006 Jul 27; Vol. 49 (15), pp. 4745-61.