Swiprosin-1 Promotes Mitochondria-Dependent Apoptosis of Glomerular Podocytes via P38 MAPK Pathway in Early-Stage Diabetic Nephropathy

Autor: Rong-Mei Wang, Zhi-Bin Wang, Yue Wang, Wei-Ye Liu, Ya Li, Ling-Chang Tong, Su Zhang, Ding-Feng Su, Yong-Bing Cao, Ling Li, Li-Chao Zhang

Publikováno v: Cellular Physiology and Biochemistry, Vol 45, Iss 3, Pp 899-916 (2018)

Background/Aims: Podocyte injury, especially podocyte apoptosis, plays a major role in early-stage diabetic nephropathy (DN). Swiprosin-1, also known as EF hand domain containing 2 (EFhd2), is a Ca2+-binding protein in different cell types. However,

Externí odkaz: https://doaj.org/article/fa4b067a3b09437cb3174617c8d70028

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Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis

Autor: Beate Winner, Dirk Mielenz, Iryna Prots, Dieter Chichung Lie, Sebastian Brachs, Sandra Loskarn, Martin Regensburger, Dorothea Reimer

Publikováno v: Stem Cell Reports, Vol 10, Iss 2, Pp 347-355 (2018)
Stem Cell Reports

Summary Swiprosin-1/Efhd2 (Efhd2) is highly expressed in the CNS during development and in the adult. EFHD2 is regulated by Ca2+ binding, stabilizes F-actin, and promotes neurite extension. Previous studies indicated a dysregulation of EFHD2 in human

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The Calcium-Binding Protein EFhd2 Modulates Synapse Formation In Vitro and Is Linked to Human Dementia

Autor: Frank J. Gunn-Moore, Abigail G. Herrmann, Eva Borger, Tara L. Spires-Jones, D.M.A. Mann

Publikováno v: Journal of Neuropathology and Experimental Neurology
Borger, E, Herrmann, A, Mann, D A, Spires-Jones, T & Gunn-Moore, F 2014, ' The Calcium-Binding Protein EFhd2 Modulates Synapse Formation In Vitro and Is Linked to Human Dementia ', Journal of Neuropathology and Experimental Neurology, vol. 73, no. 12, pp. 1166-1182 . https://doi.org/10.1097/NEN.0000000000000138
Scopus-Elsevier

Supplemental digital content is available in the text.
EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal de

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http://europepmc.org/articles/PMC4238966