The analysis of DNA interstrand crosslinks and their repair by the modified Comet assay

Autor: Swift, LP, Castle, L, McHugh, PJ, Hanada, K

Publikováno v: DNA Electrophoresis: Methods and Protocols.

DNA interstrand crosslinks (ICLs) are an extremely toxic form of DNA damage that cells experience upon exposure to natural metabolites. Moreover, ICLs are the cytotoxic lesion produced a range of clinically important anticancer agents. Therefore, imp

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Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species.

Autor: Levovich I, Nudelman A, Berkovitch G, Swift LP, Cutts SM, Phillips DR, Rephaeli A

Publikováno v: Cancer Chemotherapy & Pharmacology; Aug2008, Vol. 62 Issue 3, p471-482, 12p

Structural requirements for the formation of anthracycline - DNA adducts

Autor: Suzanne Cutts, Parker, Bs, Swift, Lp, Kimura, K., Phillips, Dr

Publikováno v: Scopus-Elsevier
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Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target.

Autor: Bielinski M; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Henderson LR; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS UK peter.mchugh@imm.ox.ac.uk., Yosaatmadja Y; Centre for Medicines Discovery, NDM Research Building, University of Oxford Old Road Campus Research Building, Roosevelt Drive Oxford OX3 7DQ UK joseph.newman@cmd.ox.ac.uk., Swift LP; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS UK peter.mchugh@imm.ox.ac.uk., Baddock HT; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS UK peter.mchugh@imm.ox.ac.uk., Bowen MJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Brem J; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Jones PS; University of Dundee, European Screening Centre Newhouse ML1 5UH UK., McElroy SP; University of Dundee, European Screening Centre Newhouse ML1 5UH UK., Morrison A; University of Dundee, European Screening Centre Newhouse ML1 5UH UK., Speake M; University of Dundee, European Screening Centre Newhouse ML1 5UH UK., van Boeckel S; Pivot Park Screening Centre 5349 AB Oss The Netherlands., van Doornmalen E; Pivot Park Screening Centre 5349 AB Oss The Netherlands., van Groningen J; Pivot Park Screening Centre 5349 AB Oss The Netherlands., van den Hurk H; Pivot Park Screening Centre 5349 AB Oss The Netherlands., Gileadi O; Centre for Medicines Discovery, NDM Research Building, University of Oxford Old Road Campus Research Building, Roosevelt Drive Oxford OX3 7DQ UK joseph.newman@cmd.ox.ac.uk., Newman JA; Centre for Medicines Discovery, NDM Research Building, University of Oxford Old Road Campus Research Building, Roosevelt Drive Oxford OX3 7DQ UK joseph.newman@cmd.ox.ac.uk., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS UK peter.mchugh@imm.ox.ac.uk., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk.

Publikováno v: Chemical science [Chem Sci] 2024 Apr 30; Vol. 15 (21), pp. 8227-8241. Date of Electronic Publication: 2024 Apr 30 (Print Publication: 2024).